ID   T1E637_CROHD            Unreviewed;       194 AA.
AC   T1E637;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=3'-5' exoribonuclease CSL4 {ECO:0000313|EMBL:JAA97353.1};
OS   Crotalus horridus (Timber rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=35024 {ECO:0000313|EMBL:JAA97353.1};
RN   [1] {ECO:0000313|EMBL:JAA97353.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Venom gland {ECO:0000313|EMBL:JAA97353.1};
RX   PubMed=23758969; DOI=10.1186/1471-2164-14-394;
RA   Rokyta D.R., Wray K.P., Margres M.J.;
RT   "The genesis of an exceptionally lethal venom in the timber rattlesnake
RT   (Crotalus horridus) revealed through comparative venom-gland
RT   transcriptomics.";
RL   BMC Genomics 14:394-394(2013).
RN   [2] {ECO:0000313|EMBL:JAG45230.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Type B {ECO:0000313|EMBL:JAG47089.1};
RC   TISSUE=Venom gland {ECO:0000313|EMBL:JAG45230.1};
RX   PubMed=25727380; DOI=10.1016/j.toxicon.2015.02.015;
RA   Rokyta D.R., Wray K.P., McGivern J.J., Margres M.J.;
RT   "The transcriptomic and proteomic basis for the evolution of a novel venom
RT   phenotype within the Timber Rattlesnake (Crotalus horridus).";
RL   Toxicon 98:34-48(2015).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
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DR   EMBL; GAAZ01000590; JAA97353.1; -; mRNA.
DR   EMBL; GBKC01000840; JAG45230.1; -; Transcribed_RNA.
DR   EMBL; GBKD01000529; JAG47089.1; -; Transcribed_RNA.
DR   AlphaFoldDB; T1E637; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd05791; S1_CSL4; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR039771; Csl4.
DR   InterPro; IPR019495; EXOSC1_C.
DR   InterPro; IPR025721; Exosome_cplx_N_dom.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR003029; S1_domain.
DR   PANTHER; PTHR12686; 3'-5' EXORIBONUCLEASE CSL4-RELATED; 1.
DR   PANTHER; PTHR12686:SF8; EXOSOME COMPLEX COMPONENT CSL4; 1.
DR   Pfam; PF14382; ECR1_N; 1.
DR   Pfam; PF10447; EXOSC1; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF110324; Ribosomal L27 protein-like; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Exosome {ECO:0000256|ARBA:ARBA00022835}.
FT   DOMAIN          65..146
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000259|SMART:SM00316"
SQ   SEQUENCE   194 AA;  21203 MW;  9CD360E7750D468D CRC64;
     MAPARYCVPG EQLCSLEEGT PGNGTYTRHG SIFASLAGCF MKKSENGTLP VISVMRDVES
     QLLPDVGAIV TCKVCSINSR FAKVHILYVG STPLKSPFRG TIRREDIRAT EKDKIEVYKS
     FRPGDIVLAK VISLGDAQSN YLLTTAENEL GVVVAHSEAG VQMVPISWCE MQCPSTHGKE
     LRKVARVQPQ FLQT
//