ID   T1E6H2_CROHD            Unreviewed;       245 AA.
AC   T1E6H2;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Alpha-aspartyl dipeptidase-like protein {ECO:0000313|EMBL:JAA97723.1};
OS   Crotalus horridus (Timber rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=35024 {ECO:0000313|EMBL:JAA97723.1};
RN   [1] {ECO:0000313|EMBL:JAA97723.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Venom gland {ECO:0000313|EMBL:JAA97723.1};
RX   PubMed=23758969; DOI=10.1186/1471-2164-14-394;
RA   Rokyta D.R., Wray K.P., Margres M.J.;
RT   "The genesis of an exceptionally lethal venom in the timber rattlesnake
RT   (Crotalus horridus) revealed through comparative venom-gland
RT   transcriptomics.";
RL   BMC Genomics 14:394-394(2013).
RN   [2] {ECO:0000313|EMBL:JAG45773.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Venom gland {ECO:0000313|EMBL:JAG45773.1};
RX   PubMed=25727380; DOI=10.1016/j.toxicon.2015.02.015;
RA   Rokyta D.R., Wray K.P., McGivern J.J., Margres M.J.;
RT   "The transcriptomic and proteomic basis for the evolution of a novel venom
RT   phenotype within the Timber Rattlesnake (Crotalus horridus).";
RL   Toxicon 98:34-48(2015).
CC   -!- SIMILARITY: Belongs to the peptidase S51 family.
CC       {ECO:0000256|ARBA:ARBA00006534}.
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DR   EMBL; GAAZ01000220; JAA97723.1; -; mRNA.
DR   EMBL; GBKC01000297; JAG45773.1; -; Transcribed_RNA.
DR   AlphaFoldDB; T1E6H2; -.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd03146; GAT1_Peptidase_E; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR005320; Peptidase_S51.
DR   PANTHER; PTHR20842:SF0; ALPHA-ASPARTYL DIPEPTIDASE-RELATED; 1.
DR   PANTHER; PTHR20842; PROTEASE S51 ALPHA-ASPARTYL DIPEPTIDASE; 1.
DR   Pfam; PF03575; Peptidase_S51; 1.
DR   SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
SQ   SEQUENCE   245 AA;  27337 MW;  B76EBC6388B1CEC8 CRC64;
     MENRRRLLLV SNSTLYGGGY LDHCQEQIKT FLGAQVRKIL FVPYALHDQT AYATLAREKL
     ESLGYGLDSI HESSDPREAV RKAEAIFIGG GNTFRLLKML YDNDLIHPIR KRVLEDGIPY
     IGSSAGTNVA TVSINTTNDM PIVYPPSLTA LQLVPFNINP HYLDPDVNST HMGETREKRI
     MQYHEELNTP PVLGLREGSL LLVEGNKATL QGKTGARLFV RGSAPTEHEH GTDFSFLLNE
     SFKIV
//