ID T1E751_CROHD Unreviewed; 477 AA.
AC T1E751;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=C-ets-2-like protein {ECO:0000313|EMBL:JAA97632.1};
OS Crotalus horridus (Timber rattlesnake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX NCBI_TaxID=35024 {ECO:0000313|EMBL:JAA97632.1};
RN [1] {ECO:0000313|EMBL:JAA97632.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAA97632.1};
RX PubMed=23758969; DOI=10.1186/1471-2164-14-394;
RA Rokyta D.R., Wray K.P., Margres M.J.;
RT "The genesis of an exceptionally lethal venom in the timber rattlesnake
RT (Crotalus horridus) revealed through comparative venom-gland
RT transcriptomics.";
RL BMC Genomics 14:394-394(2013).
RN [2] {ECO:0000313|EMBL:JAG45635.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Type B {ECO:0000313|EMBL:JAG47331.1};
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAG45635.1};
RX PubMed=25727380; DOI=10.1016/j.toxicon.2015.02.015;
RA Rokyta D.R., Wray K.P., McGivern J.J., Margres M.J.;
RT "The transcriptomic and proteomic basis for the evolution of a novel venom
RT phenotype within the Timber Rattlesnake (Crotalus horridus).";
RL Toxicon 98:34-48(2015).
CC -!- FUNCTION: Transcription factor. {ECO:0000256|PIRNR:PIRNR001698}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019}.
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DR EMBL; GAAZ01000311; JAA97632.1; -; mRNA.
DR EMBL; GBKC01000435; JAG45635.1; -; Transcribed_RNA.
DR EMBL; GBKD01000287; JAG47331.1; -; Transcribed_RNA.
DR AlphaFoldDB; T1E751; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045688; Ets1_N_flank.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR016311; Transform_prot_C-ets.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF209; PROTEIN C-ETS-1; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF19525; Ets1_N_flank; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR001698};
KW Nucleus {ECO:0000256|PIRNR:PIRNR001698, ECO:0000256|RuleBase:RU004019};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR001698};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR001698}.
FT DOMAIN 86..171
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 371..451
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 277..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 54770 MW; 613F0B6D7FD489E7 CRC64;
MNEFGIKNMD QVAPVCSVYR ELFKRQPAFD SFEGALFTEF YPPLNEDQTL QEVPTGLDSI
SFESNSSELP LLTPCSKAVM SQALNATFSG FTKEQHRLGI PNNPWLWTQY HVCQWLLWAT
NEFSLVNVNF ERFAMNGQEL CNLGKEHFLE LAPDYVGDIL WEHLDQMIKD NEEKPQDQYV
ENSHLTSSPH WVNNNSLGTN VEQMQYCTHV PSYPKTLSFQ KNRALGDVCQ TTIGPNLVNL
KQEFQMFPKA QLETVNVNYC SMNQDFTRNN LNLVLDNTSK PREHDSNDSG TESYEGSDSL
LQSWNSQSSL VDVQRVPSYD SFEDDCSQSL CLNKPTMSFK DYIQERSDPV EQGKPVIPAA
ILAGFTGSGP IQLWQFLLEL LTDKSCQAFI SWTGDGWEFK LADPDEVARR WGRRKNKPKM
NYEKLSRGLR YYYDKNIIHK TSGKRYVYRF VCDLQNLLGY TAEELHAMLG VQPDTED
//
