ID T1ED62_HELRO Unreviewed; 716 AA.
AC T1ED62;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00026121};
DE EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
GN Name=20194514 {ECO:0000313|EnsemblMetazoa:HelroP101643};
GN ORFNames=HELRODRAFT_101643 {ECO:0000313|EMBL:ESN98461.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP101643, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98461.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP101643}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01005884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097144; ESN98461.1; -; Genomic_DNA.
DR RefSeq; XP_009023416.1; XM_009025168.1.
DR AlphaFoldDB; T1ED62; -.
DR STRING; 6412.T1ED62; -.
DR EnsemblMetazoa; HelroT101643; HelroP101643; HelroG101643.
DR GeneID; 20194514; -.
DR KEGG; hro:HELRODRAFT_101643; -.
DR CTD; 20194514; -.
DR eggNOG; KOG1256; Eukaryota.
DR HOGENOM; CLU_000022_45_5_1; -.
DR InParanoid; T1ED62; -.
DR OMA; MIDIWIS; -.
DR OrthoDB; 443463at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272:SF32; AMP-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 107..523
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 79910 MW; 3092962109DFE0E8 CRC64;
MTSVDAGTNH NKNVEMRRRT GRSESGKALT DSGIFEDSQI LSSPGETEKD YNTYNSIEDK
LCTFTNDFGK LAEADSLSTV NAGEAVKIRL TRDEKFHIAP ITVMTMFQRA VKSFPYRPAL
MYQHNHGQKW NCITFEEYYD LTLKAAKSFI ACGLEEHHGV GLLGFNSCEW FISYMGSIMA
GGLATGIYST NGAESCWFVL NNAKCSVAIV ENNAQLQKVL SVWERLPHLK AIVQYRDPLE
CNMSNVYTWE EFMKLGNGLS DGELERRWAN QAPNKCCTLI YTSGTTGDSK GVMLSHDNLI
WTAAVCGRQA RLDICEDVLV SYLPLSHVAA QVLDMFIPVV YGATVYFAQP DALKGSLGET
LKDVHPTVFL GVPRVWEKMQ EKMVAVGKTQ GVVTRTLVEV AKYIGYWGNM SLMNGGTVPY
GWTLADMLVF KKVRKALGFE RCKFCMSAAA PILKDTLDFF MSLNMPILEI YGMSESTGPH
TLSFPWQYRT TSSGVELFGV QTKLSGEDSE IRMNGRNVFM GYLNMTEKTI ETLDEDGWLK
SGDQGRRDED GYLYITGRIK ELIITAGGEN VAPIPIEDCL KESLPCVSNC MLVGDGKKFL
SMLITLKTKV DVATTEPLDE LHPFTIEWCQ KIGLPSDVTT LTQLREHMAG KVATAMQAVI
DRCNKKAISR AQVIQKWSIL PRDFSIFYGE LGPTLKLKRK VVANMYKSTI DAFYAQ
//
