ID T1EDU0_HELRO Unreviewed; 314 AA.
AC T1EDU0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Laminin IV type A domain-containing protein {ECO:0000259|PROSITE:PS51115};
GN Name=20194742 {ECO:0000313|EnsemblMetazoa:HelroP105364};
GN ORFNames=HELRODRAFT_105364 {ECO:0000313|EMBL:ESO12458.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP105364, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO12458.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP105364}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO12458.1; -; Genomic_DNA.
DR RefSeq; XP_009009178.1; XM_009010930.1.
DR AlphaFoldDB; T1EDU0; -.
DR STRING; 6412.T1EDU0; -.
DR EnsemblMetazoa; HelroT105364; HelroP105364; HelroG105364.
DR GeneID; 20194742; -.
DR KEGG; hro:HELRODRAFT_105364; -.
DR CTD; 20194742; -.
DR eggNOG; KOG3509; Eukaryota.
DR HOGENOM; CLU_886449_0_0_1; -.
DR InParanoid; T1EDU0; -.
DR OMA; REDAYWI; -.
DR OrthoDB; 5491831at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR CDD; cd00055; EGF_Lam; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF365; NETRIN-A-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 2.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00281; LamB; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS51115; LAMININ_IVA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 1..153
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT REGION 290..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 314 AA; 35537 MW; A6475F668F046E49 CRC64;
MIHINTPHRE DAYWILPSKY YTYPLSLYKG ALRYTASYYS SYPFHYGKPD VILRVEDTSQ
FLYYTYPDNT FPVDTPKEFV IPLYEAGWVD AQNNPVSRDT FMGVLKSLQS IWVRAKFSTG
VDVEDRLSAV SVEYSVRDYE VELGQNGYPI LEKCHCLPGY QGQWCEDCQP GYRKTVDDMH
YVHCEQLDNI QCDPRTGHCQ GCPHNTVGRN CECPHGFYMD RANNCEPCLC PVDASIDGRE
KVSCSLSSVG TLVCHNCPVG STGSRCERCL FDYEGDPSIF GGRCVPTSDV PRPPVIETSD
GDQKIDDKSF GDTM
//
