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Database: UniProt
Entry: T1EGM2_HELRO
LinkDB: T1EGM2_HELRO
Original site: T1EGM2_HELRO 
ID   T1EGM2_HELRO            Unreviewed;      1864 AA.
AC   T1EGM2;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-SEP-2017, entry version 35.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=20195722 {ECO:0000313|EnsemblMetazoa:HelroP119038};
GN   ORFNames=HELRODRAFT_119038 {ECO:0000313|EMBL:ESN92382.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP119038, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP119038, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Simakov O., Marletaz F.,
RA   Cho S.-J., Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T.,
RA   Lv J., Arendt D., Savage R., Osoegawa K., de Jong P., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESN92382.1, ECO:0000313|EnsemblMetazoa:HelroP119038, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP119038}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AMQM01007584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB097642; ESN92382.1; -; Genomic_DNA.
DR   RefSeq; XP_009029484.1; XM_009031236.1.
DR   EnsemblMetazoa; HelroT119038; HelroP119038; HelroG119038.
DR   GeneID; 20195722; -.
DR   KEGG; hro:HELRODRAFT_119038; -.
DR   CTD; 20195722; -.
DR   OMA; CMSNHTT; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015101};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     36     59       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    168    187       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    297    322       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    666    690       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    711    731       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    743    764       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    784    813       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    833    852       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    873    894       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1147   1169       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1181   1199       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1219   1245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1265   1291       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1389   1412       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1473   1490       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1502   1523       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1535   1553       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1600   1624       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1686   1709       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1730   1765       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ESN92382.1}.
FT   NON_TER    1864   1864       {ECO:0000313|EMBL:ESN92382.1}.
SQ   SEQUENCE   1864 AA;  211551 MW;  3BAE69BCD6D9BFD8 CRC64;
     NTQTFVVVAR DKTIFRFSSS NGFFFLSPWN PIRRGALVVL THPLFSLLVM VVILVNCVFM
     AINKEIPYTE CVNIFTSIYT VEGTVKMLSR GFILADFTYL RDAWNWLDFV VVSSAYITMF
     VGSGEGGGKV AVLRTFRVFR ALKTVAVVPG LKTIVGALME AVRRLRDVMI LSLFVLSIFA
     LIGLQLYQGT SLFLHVRACT EKFAVEGNTH TNTQTHTHTH TYTHMHKHTH TYTHTHIHSI
     CGEGYTCLES GFNPNFGYTT YDNFGWALLC AFRLMTQDYW ENLYQLTIKA NGPAQMFFFI
     IVIFLGSFYL VNLILAIVAM SYDDCRKQDA QAEEQELLDL MEVSMMKMVV IMQQEEEANA
     AAYLLQQQDE LNKDGEDDEE DDDDDDEDDD DDDNDYVNDV RKSLDEGEGR EVAVDWAFDR
     KSQGSNMSRA SLSKNHNVNN LPAYQSLQFA PHSQAGHHVG PIVFPCLENL DLPFADDSAA
     VTPSSEDICV FQNVRSSHFL AKSGGKPSMT LVSAGGGLGL YPSAGNNQSK IHSPTTNQSN
     NHSTRFAPNR QSGHIITQPY VPSPKLLATP TSLLLPSDQF QSTNRIRLPD FKRSEPTHFH
     WVSGRARNAN LNNGSGAVGL VVGKTKNVNC FGMEEGQSKK EFLKAKCHQI LFGWDCCPCW
     YRFAHYIELF ILDAFVDLFI TLCIVINTLF MAMDHDNMSQ QLELTLRYGN YVFTCIFTIE
     AGLKILALGL YKYLEDKWSC FDIVIVILSL IELGLSGIKG LSILRSFRLL RVFKLAKSWP
     TLNLLIGIIG RTMGALGNLC FVLAIIIFIF AVMGMQLFGP NYVAERFEEK VLPGWHFCDF
     LHAFMIVFRV LCGEWIESMW DCIRTNGYHC IPFFLLTMII GNLVLLNLFL ALLLSSFGAE
     SLKKSEEEEG PNKLQEAIDR ITRFCIYVKS HLAYLCKRGE RKLVTMDDDF NDDDDDDETG
     SRPVPLDPFD QSQQQLSPFV QSDDKATTAH HPNHNHNHQS TMSNCNHDGG SHQHRHSNHH
     NSSSKQTSLN KHASLDKQKS LDDTASSASS ITSVPSSSAS SSGDNGSQKS ILSKYSYSYD
     DVTSATRTAE GPEIHEVFVF IKYPDECCPK CCMKCCGPMF ERFDQTKVGK VWGSYRFFMF
     KLVENNYFET FIILMIMLSS LALAVEDVYI ENPERWLLKN ILKVMDKVFT VIFVLEMIIK
     QSAYGYKKYF TDAWCWLDFV IVVISLLSLG AESAGYGNIG AFRALRTLRA LRPLRAVSRW
     EGMKVVVNAL IQAIPSIFNV LLVCLVFWLI FSIMGVNLFG GKFHECRDAN DERLNASIVP
     NKKVCLQLAE EFNYTWFNPK INFDNVLIGY LALFQVATFK GWIDIMNSAI NSQSEPDAQP
     VYEIRSGMYM YFVFFIVFGA FFTLNLFIGV IIENFNMQKK KAGGSLEMLM TEDQKKYYNA
     MKKLGSKQPQ KPIPKPKIKF QLILFYITSS QKFDIFIMLI ILLNMTTMAI EHFDQSEELT
     KALYWINQVF VGIFSLECVM KLLSLRQYYF KQPWNVFDFI VVISSVATSL FVSDQVDNLP
     ISPTLLRVVR VFRVGRILRL VKSAKGIRTL LFSLAVSMPA LFNIGLLLFL VMFIYSIFGM
     SFFMHVKHTK GIDDMFNFET FFRSMIILFQ ISTSAGWDGV LAGLMNEEDC DKTPSDVRPN
     GDCGDSGQAV VFLVTYLVIS FLVVINMYIA VILENFSQAT EDVQQGLTQD DFDMYYEIWE
     KFDENASQYI PLSDLSRFVD ELEAPLRLPA PNTFKLVSLN IPICENDRVH CLDILDALTK
     NYLGTGEVAD DLADIKKGPD RKDYQPISST QRRQRENYAA KVIQNCWRKY RRKKNGDGDD
     DDDD
//
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