ID T1EGM6_HELRO Unreviewed; 1120 AA.
AC T1EGM6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=20195726 {ECO:0000313|EnsemblMetazoa:HelroP119222};
GN ORFNames=HELRODRAFT_119222 {ECO:0000313|EMBL:ESO04704.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP119222, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO04704.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP119222}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AMQM01004190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096457; ESO04704.1; -; Genomic_DNA.
DR RefSeq; XP_009017283.1; XM_009019035.1.
DR AlphaFoldDB; T1EGM6; -.
DR STRING; 6412.T1EGM6; -.
DR EnsemblMetazoa; HelroT119222; HelroP119222; HelroG119222.
DR GeneID; 20195726; -.
DR KEGG; hro:HELRODRAFT_119222; -.
DR CTD; 20195726; -.
DR eggNOG; KOG1025; Eukaryota.
DR HOGENOM; CLU_003384_5_1_1; -.
DR InParanoid; T1EGM6; -.
DR OMA; GHEYMNQ; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0009925; C:basal plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0022008; P:neurogenesis; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd00064; FU; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF566; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 6.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 779..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 849..1118
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 882
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1120 AA; 125473 MW; 13BC1F4DA644FCA2 CRC64;
CPGTTYRHAY EAHHKNYYEF LKQRYTNCNI VDGNLEINFL VKRQDGYQED EEAGFDLGFL
KDIKEVTGYV MIQYNEIFHL NLSSLLLIRG QQLCNCFVVS VSSFVNNCSL FIPVIIMAHL
SFSNCPEISR GDVMIYNNGA LRFVDTVNWV DVLSDGSSRV FMSRNNAICE LGCHPSCECH
PSCADLTGQP YCWGPGPEMC HRLTKVHCEC DNRCEPNSTV RCCSKECAAG CSGSSRKCLA
CKNFYNDGVC EENCPVQHIY DSPQYKTLEN PKHKYAYGST CVKPCPNHLL MDKQACVKHC
AANSMIVGDS CVECGSDGQK PCLVEGVAVN ASSFIGCQVV DGNLMFDDFT WNGDVYLNLC
HKLFLSHVSE EWKYLESVEE VTGFVRMHFR TSNYESLSFL KNLKTIRGVF LDELGHSLGI
AATNFTSLGL DSLTAIKYGN VKISRNKKMC YVQSINWSAI LKSPDDQRVI IGNNNNNCES
EGKLCHPECS DDGCWGPGDH QCISCRNFKF QNKCVLSCQS IPLAYASSNT TCSLCHEQCL
DTCDGPGAEN CTTCRFVRDR DTCTTSCPKT KYTDKNNHCQ NCHKNCGEYG CTGPLNNIGA
NACNSCDLVS FEKVGDSLNA TSCMPITKMC ATGLYRTILI DYPSNHSLHR KQGCKPCHPE
CLACWDYGTS TSYCHPCKHF KEEDKCVSSS IKRKNVEDYD ERSCLPCHTS CLTCYGPDPH
QCYTCKHYIV YHDYQNKELG FNCSENCPAN LPHKLARDVN GMKITECVED DYASKTGRIL
AIVLPICILT VIAIVAISLG VVAYKKSKAK TKIAMAAVNL LNGIEDMPLN PSGLRPNMSR
LNIISESELR LGEKIGQGAF GSVFKGVWTP SKKNVRVYVA IKILHETWSN TDVRQPDYLS
EVEIMCNVKN EYCVQILAVC LASKTMIVTQ LMPYGCMLDF IRDNQNNLGS KVLLNWARQI
ASGMAYLEEV RIVHRDLAAR NVLVQNDNHV RITDFGLSKL LDAGTNIYYS KGGKIPIKWL
ALESLRHKKF THSSDVWSFG VTLWEMFTFG DSPYENVKSE NMVEVLEKGD RLAQPTICTI
DVYMVMIKCW LVDADSRPTF SSLVETFSHM AEDPTRFLFI
//
