ID T1EGW6_HELRO Unreviewed; 322 AA.
AC T1EGW6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=RIH domain-containing protein {ECO:0000259|Pfam:PF01365};
GN Name=20195816 {ECO:0000313|EnsemblMetazoa:HelroP123029};
GN ORFNames=HELRODRAFT_123029 {ECO:0000313|EMBL:ESN99826.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP123029, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN99826.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP123029}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01005759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097070; ESN99826.1; -; Genomic_DNA.
DR RefSeq; XP_009022174.1; XM_009023926.1.
DR AlphaFoldDB; T1EGW6; -.
DR STRING; 6412.T1EGW6; -.
DR EnsemblMetazoa; HelroT123029; HelroP123029; HelroG123029.
DR GeneID; 20195816; -.
DR KEGG; hro:HELRODRAFT_123029; -.
DR CTD; 20195816; -.
DR eggNOG; KOG3533; Eukaryota.
DR HOGENOM; CLU_864860_0_0_1; -.
DR InParanoid; T1EGW6; -.
DR OMA; ECETACF; -.
DR OrthoDB; 5480299at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF4; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01365; RYDR_ITPR; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 115..261
FT /note="RIH"
FT /evidence="ECO:0000259|Pfam:PF01365"
FT REGION 76..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 322 AA; 36980 MW; 023B85369BD1747C CRC64;
LYNYPQLVTA SLKLIFRHFS QKQETISAIK QVQLLITYSD SKNYKQIKCD LEELRLLVEK
SELWVTKKKS TNKVLCNNSS IGHHQHPGGH EGQGSSQGHT APRSSQGQRP VQSRSSRAYN
QRLLKNLGVH EAMIELLQIQ YDKKNDRSMN EIIQLVHIFI QNFCYRNPAN QNLIHQNFNL
FLSPGILECE TACFIYKDNA NLCANLSQST VQHYITCIEK YGRKSEYLKF LQIIVRSETY
VYHRKAQDMI MTGLMDSSEE VLHFYTDSSS IQSLVENMKS QIGPLDPRSS LAYHVDLVNL
LACCTEGKNV FTEIRCHSLL SL
//
