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Database: UniProt
Entry: T1EHR2_HELRO
LinkDB: T1EHR2_HELRO
Original site: T1EHR2_HELRO 
ID   T1EHR2_HELRO            Unreviewed;       677 AA.
AC   T1EHR2;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-SEP-2017, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO08636.1, ECO:0000313|EnsemblMetazoa:HelroP128997};
GN   Name=20196112 {ECO:0000313|EnsemblMetazoa:HelroP128997};
GN   ORFNames=HELRODRAFT_128997 {ECO:0000313|EMBL:ESO08636.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP128997, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP128997, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Simakov O., Marletaz F.,
RA   Cho S.-J., Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T.,
RA   Lv J., Arendt D., Savage R., Osoegawa K., de Jong P., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESO08636.1, ECO:0000313|EnsemblMetazoa:HelroP128997, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP128997}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AMQM01003297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMQM01003298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB096080; ESO08636.1; -; Genomic_DNA.
DR   RefSeq; XP_009013566.1; XM_009015318.1.
DR   EnsemblMetazoa; HelroT128997; HelroP128997; HelroG128997.
DR   GeneID; 20196112; -.
DR   KEGG; hro:HELRODRAFT_128997; -.
DR   CTD; 20196112; -.
DR   KO; K04911; -.
DR   OMA; VPKAVWD; -.
DR   OrthoDB; EOG091G0OXR; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015101};
KW   Ion channel {ECO:0000256|SAAS:SAAS00091826};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM    229    249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    261    279       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    310    333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    354    380       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    449    473       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       92    144       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      551    668       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   NON_TER     677    677       {ECO:0000313|EMBL:ESO08636.1}.
SQ   SEQUENCE   677 AA;  77274 MW;  E4B22D6528004DE2 CRC64;
     MPGRKGLLAP QNNFLDTIAT RFDGTHSNFV LGNSQAQGHP IVYCSDGFCE LTGYARAQVM
     SKNCICKFLF GPLTSAEEIK KLETSVETKS ELKSELQLYR KNGTMFWCLL DMVPIKNEKG
     EVVLFLVSHK DITFSRKHNA KTSRYGFRKG SHKGDDGTGN KYQRRRSRAV LYQLSGTFSR
     QTSAKSKLQL NKIKTFSGTN DIPEYKVQEI KRSRFILLHY SFTRICWDWL ILLCTFYIAI
     MVPYNAAFIA TSEGNNQRIT LYFDVFVEML FIIDIIFNFQ TTYVNKSGQV IYQPKLIAFN
     YLRGWFVLDL LAAIPFDLLY AFQVDTGTLI HLLKGARLLR LARLLQKLDR YSQHSFVVLT
     LLMAMFTVLA HWLACVWYFL GREELLQHPA NWTVGWLYQL AEKLDEPIVN KTNLPPISVS
     YVSALYFTCT SLTSVGFGNV SPNTTAEKIF SVIAMLIGAL MHALVFGNVT AIIQRMYARR
     AIYQSKTRDL KDFFRAHHIP APLKQRMQEY FQTTWSLNSG IDRQEVMKDF PVEMQGDIAM
     HMHREVLSLP IFENASQGCL KAIALMIKPM FCAPGEYIIH KGDVMTCIYF VINGSMEILK
     ESMVVAILGK GDLFGTDVGY TDPIVKSNCE VKSLTYCDLL CIPLDGLHSI LAMYPEMAEK
     FETDLVHDLT YILREGY
//
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