ID T1EHU2_HELRO Unreviewed; 663 AA.
AC T1EHU2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN Name=20196142 {ECO:0000313|EnsemblMetazoa:HelroP130545};
GN ORFNames=HELRODRAFT_130545 {ECO:0000313|EMBL:ESO07820.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP130545, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO07820.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP130545}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR EMBL; AMQM01003530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096183; ESO07820.1; -; Genomic_DNA.
DR RefSeq; XP_009014431.1; XM_009016183.1.
DR AlphaFoldDB; T1EHU2; -.
DR STRING; 6412.T1EHU2; -.
DR EnsemblMetazoa; HelroT130545; HelroP130545; HelroG130545.
DR GeneID; 20196142; -.
DR KEGG; hro:HELRODRAFT_130545; -.
DR CTD; 20196142; -.
DR eggNOG; KOG2126; Eukaryota.
DR HOGENOM; CLU_004298_2_1_1; -.
DR InParanoid; T1EHU2; -.
DR OMA; TERRKIC; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..663
FT /note="GPI ethanolamine phosphate transferase 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010979857"
FT TRANSMEM 435..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 443..640
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
FT REGION 535..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 75047 MW; 5DF30BF15116D378 CRC64;
LYIIGILIFT SGFLLRRTVV EETSKCSSSW SPGTSSFLKS HCGNSGKFSK AVLLIIDALR
YDFLTFNDSS EVKLNLPYQN NFNHVNSLLK SQPNNAKLFK FVADPPTTTL QRLKGLTTGS
LPTFVDAGSN FNKEEITEDN FIDQLVHNNK SIAFVGDDTW MGLFPNRFSD VHSFPSFNVK
DLDTVDNGVI ENFDRLIRFT NWTLLVGHML GIDHCGHTFG PHHIKMKEKL IQMDNFIRNI
TESLNNDTIL FVMGDHGMTK TGDHGGDSDE EVDAGLFVYS KLPFSRHQNK ISTISQVDLV
PTFSLLLGLP IPYQNLGIVI PELFPSEDDN LSDDSKHASS STEFQALVVL YANAEQIADY
VEKYLNISGS SPKLQELLIS YEKLKADCFY FIESIRSKHH VIDNAKMKKL IKNLLKFMTS
VRNVLKEQWA KFDTTLMFIG ILFIILTVLL NLRNVPTDMI IALLLLASQH FYSVGHHPTI
SSIKWDSVYY ILEGDNNPHL LISLILYFNT FAPHIIVALS LPLFIYWPLT NNATGSRAGS
KKQSEVESVT DATVRNSSGS DATSNDGHAD NIKGEYVLND DNEKTRSLFH QLCFKAILFL
SLKVLAMMLC VTIHRRHLMV WKIFAPRFIY EIAGFLVFSI TIIFDYLFLL RTKRAVDRFV
NKI
//
