ID T1EUB5_HELRO Unreviewed; 321 AA.
AC T1EUB5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=E2 domain-containing protein {ECO:0000259|PROSITE:PS51870};
GN Name=20200165 {ECO:0000313|EnsemblMetazoa:HelroP163650};
GN ORFNames=HELRODRAFT_163650 {ECO:0000313|EMBL:ESN96573.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP163650, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96573.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP163650}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the APP family. {ECO:0000256|PROSITE-
CC ProRule:PRU01218}.
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DR EMBL; AMQM01001414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097495; ESN96573.1; -; Genomic_DNA.
DR RefSeq; XP_009025719.1; XM_009027471.1.
DR AlphaFoldDB; T1EUB5; -.
DR STRING; 6412.T1EUB5; -.
DR EnsemblMetazoa; HelroT163650; HelroP163650; HelroG163650.
DR GeneID; 20200165; -.
DR KEGG; hro:HELRODRAFT_163650; -.
DR CTD; 20200165; -.
DR eggNOG; KOG3540; Eukaryota.
DR HOGENOM; CLU_866786_0_0_1; -.
DR InParanoid; T1EUB5; -.
DR OrthoDB; 2907766at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.120.770; Amyloid precursor protein, E2 domain; 1.
DR InterPro; IPR008155; Amyloid_glyco.
DR InterPro; IPR024329; Amyloid_glyco_E2_domain.
DR InterPro; IPR019745; Amyloid_glyco_intracell_CS.
DR InterPro; IPR036176; E2_sf.
DR PANTHER; PTHR23103; ALZHEIMER'S DISEASE BETA-AMYLOID RELATED; 1.
DR PANTHER; PTHR23103:SF15; AMYLOID-BETA-LIKE PROTEIN; 1.
DR Pfam; PF12925; APP_E2; 1.
DR SUPFAM; SSF109843; CAPPD, an extracellular domain of amyloid beta A4 protein; 1.
DR PROSITE; PS51870; APP_E2; 1.
DR PROSITE; PS00320; APP_INTRA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 229..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..104
FT /note="E2"
FT /evidence="ECO:0000259|PROSITE:PS51870"
FT COILED 62..89
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 321 AA; 35898 MW; CF3B24A060227219 CRC64;
MKIKEQKKVA LENYLKSLND VPIKVPYVLT TLKRYIKSEQ RDRNYVIESI KEQKKLHPEM
PASGLDDKID EKLREIDQAV DEALEMLEKI PKHGKKMRQH IDDFITKLPT VAQPNFEKSI
TPSLFSSSSL LSSSSILTSS SSLSSSPSGL ENKSETDIHG LVTSSWQMSN DGAHLDHVLD
DVMYKHEPVA GHMMKNEMNV EQPRYRRVQP IGSGDSNGNM YMRHRDEKLT NPIGIILTSI
GLVLIIVIGI IALIKRVNSV PVTNGYLDKP LKRGEAFKRT TSIAGGSTAV KSGGVQSRQN
SVNGYENPTY RYYEATRVAV S
//
