ID T1EZD8_HELRO Unreviewed; 1955 AA.
AC T1EZD8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN Name=20201938 {ECO:0000313|EnsemblMetazoa:HelroP167440};
GN ORFNames=HELRODRAFT_167440 {ECO:0000313|EMBL:ESO10925.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP167440, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO10925.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP167440}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01002783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095858; ESO10925.1; -; Genomic_DNA.
DR RefSeq; XP_009011194.1; XM_009012946.1.
DR STRING; 6412.T1EZD8; -.
DR EnsemblMetazoa; HelroT167440; HelroP167440; HelroG167440.
DR GeneID; 20201938; -.
DR KEGG; hro:HELRODRAFT_167440; -.
DR CTD; 20201938; -.
DR HOGENOM; CLU_234709_0_0_1; -.
DR InParanoid; T1EZD8; -.
DR OrthoDB; 2958415at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR CDD; cd00185; TNFRSF; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR42264; EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR42264:SF3; F-BOX DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 390..486
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 15..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1417..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1582..1618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1689..1712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1734..1767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1796..1928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1486..1539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1796..1850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1851..1871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1872..1890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1903..1917
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1955 AA; 222561 MW; E8D93A765CC7DE3B CRC64;
MEIKSEISVE RQAKIVEAKS SSKPTVETDS MYTSQKKTRN NSNNNNNGNN NNSNSNSSRN
RTNNFINCNL NCNLNSNLNS NLNSNLNSID NINSNNFNTS TSSNSNDNFN SNNNSSNDNT
NNTSNDNIKN NNNDNTSSSN DNTNNNSNNN IRNNSNDNIR NNNNTNNNSN NNIRNKDNTN
NNNIRNNSND NISSSNDIDN TNNYSNDNIR NNKNNDNTNN YSNNNIRNNS NDNISSSNDI
DNTNNYSNDN IRNNKNNDNT SSSNDNDNTN NNTNNNGDDK SKKISIAGNP ENVYYYDQNY
DLKNIIEEHD DVDDILVPLS HNNIRIRPGR ISKQDAWVMQ ELQYAFDKTQ RNEVAFLENS
QVHVSTEDVF KGKIGHGLIQ RQSYVFRVRP DIVHMPGNKT YTERTLYVHR GDDAIVPCYD
NNINILSTKW IQFTWINNTN QKFDYDEVLF ERVSLTNDQE LWIKGAHLND TGMYTCSVSA
ITTEFDTPFY LYNVINVYVY EMSHISLVFH YSFPYVTKSM PCNPMYEKDV LKQAEELLCQ
IKDKCRYRVR VTCDHPAPRP ENPLIEPTTA KPSNFDDHNK LKLSGFILQE NSFKLANCSD
SCTIFQRAMH VSKVRSVVSE AFDRLNLPKD IDPQANVEEF FIFYCKPGYF LHKFACIPCP
PGTYLLRGGP NDRCIRCETD TYQLQVGSKE CIPCERNMFT FGLLSREASR CSFVSEHLIV
SNVVFFIVGS IVGIIALTGF TINLLTQFLA CMTKINESAT QVREEKPKTE LFQIFPIFQG
KEQKPETMDA SPKANWKNKI FDDEPKPEDT LRTTTFFDIF FKKAEQPEQQ TSKNNNLPAN
RQSKIFQKLQ NLSQSFDESS INVLDNRSHN NSNTPTPKFY PKRAKKMISP FEKQLIKNSE
WKKNKNNNRI YRKKIMNIFT KFLKKITTSF RGEYHEKKDL SYISSTEVYS KSPMFRRGLE
ESLMSPAKSD FESSFSNVVP AVDNSSKLKN KKVTGFLNPE NSYRAVKLKH EKNLSKKLNH
SFLKDSKDFK SLSFSGKDVQ SPSNELQSAF HHPLSGLFTG SQLAYDTRVL LNNSAAQLSE
NVSHISMLSN EKISNEKNNS KIRSTNQLAN NKQNLLKQDS TSNETRTLRQ AFNELLDEVN
QPTSNENFIK KFTTFVEYLD DGNKNIPTDP TICSHKPLKQ KSSGDCQLMN SNFNKLTIKS
KKIKFLNTLF ENYLIELKNV STKNSTESRN CLLNSLKEQY ALATSKSNRK LSKHKQHHKT
NKNENNVETD EKNLPKEEEK QQDNFTVPSE LLNKAFDELI DGYKCKLDRK NMMMKKSSLL
DLIDQKSTLS LARNCDKSNN LLSGHESVAS SNQVCSELSG VMISLKTSKN VKSIKEKFKN
LVKDLDNPDL IVETSSKIKN LLNKVEKNFN DRMSAELMKR ESQSKRVGKD GTDHKNETFE
DEKYSKQEKT STEKNHKRSN TGKNVESSKK RDPSHHKMHS IPARKMSKPA SSQNCNDNNS
SSNNNNKNNN NNVVIDISSN DNAKFDITNH MNDDASTNHN ASYSDEDDHK SIENVSNGSL
HFQTFKVANN DDIIKSSFSS ISPINKLSNR SPPTSMPKIS NSGRTTSASR NKNKEKTTKL
NATTTSTTIT SILKKLTPPT TLTTKSTAST TTSSSMKIIP VPRNSTRKLK QSNYIYTNSE
NNINNINVKN NHNNNNSNDN NNNNINNNSF CDDNQNSRAV EVKIVRKYLT NDQLYSSDNN
NNVCTEKQNI YNNNNNSNNN NNNNTYNNIY TSFHPTITAR KSRIEKRNYN ESLLGAGRTN
QSNISNNINY NNSNNINNNN TNNINNNNSS SNTNNNTNNN TNTSNRRMND NDASKSNKMK
IANKKRTTHS DNKITTNSTT TTTTNNITKD LLHDSRYDKT PITDEDDDDE DVESSDDDDC
KKAECDNANG DADVSIQKLN FNRKNAVTRT KFFVT
//
