ID T1F3P6_HELRO Unreviewed; 1725 AA.
AC T1F3P6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20203445 {ECO:0000313|EnsemblMetazoa:HelroP171012};
GN ORFNames=HELRODRAFT_171012 {ECO:0000313|EMBL:ESO06977.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP171012, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO06977.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP171012}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AMQM01003743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096275; ESO06977.1; -; Genomic_DNA.
DR RefSeq; XP_009015073.1; XM_009016825.1.
DR STRING; 6412.T1F3P6; -.
DR EnsemblMetazoa; HelroT171012; HelroP171012; HelroG171012.
DR GeneID; 20203445; -.
DR KEGG; hro:HELRODRAFT_171012; -.
DR CTD; 20203445; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_1_1_1; -.
DR InParanoid; T1F3P6; -.
DR OMA; CYFHALI; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 19..278
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 292..634
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 662..879
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 1119..1239
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 1271..1407
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 1414..1695
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 300..327
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 507..562
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 827..899
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1725 AA; 196498 MW; A90242B22F4FD0D0 CRC64;
MNKMIADALD GYNEVNTMMS LVLFEDAIYH IMRINRILES PRGNALLIGV GGSGKQSLSR
LAAYISNLDV FQVSLKKGYG LNDLKADLAV LYLKAGLKNL GVMFLMTEGQ VPDEKFLVLI
NDLLATGEIP ELFPDDEIDN IVNAMRPEVK ANGLFDSREN CWKFFIERIR QFLKVVLCFS
PQGSSLRNRS RKFPAIINTT CIDWFHEWPI EALVSVSRRF LGEIEGLTPD MCDSISDFMS
HVHQSVNEVS VSYLMNERRY NYTTPKSFLE QISLYRNLVS SKFNEIHQNT VRLVNGLEKL
ESASGQVDEL KKTLVVQEKE LAIKNEEANK LIAVVKGETD KVSAERAITN DEEKKVKIIN
DEVSVKFIEC EADLRKAQPA LDAAKAALDT LNRNNLTELK GFTSPPSAVV KVAAAVIVLM
SAPSGKVPKD RGWRIAKGIM NKVDDFLLSL INYKKESIPP MVQKAVQPYL DDPEFEPEYI
KTKSFAAAGL CAWVINIMKF YEVFCEVEPK RLALEDATRQ LNDAEQKLNL LRQKLAVLQD
ALGKLTKEYE KATKAKAKCQ AEADQTAKTI DLSNRLVLGL ASENVRWHQA VETFNIQAGT
VPGDILLVTA FISYVGCFTK PYRIDLMENH WLPYFRALPN PIPTSENLDI MGLLSDDAKL
AKWQNEGLPN DRMSSENATI LTNAERWPLM IDPQLQGIKW IKRKYGDKLV VVRLNQKNYI
DKIEKAISDG EVVLIENIDE SIDPILDPII GRNTIKKGKV IKVGDKEINF NKNFRLILHT
KLANPHYKPE LQAQTTLINF TVTKDSLEDQ LLAMVVAKEQ PELEVLKADL TRQQNEYKIT
LKHLEDSLLA RLSEASGNFL GDYELVENLE TTKRTSADVE EKVKEAKVTE AKINEFREAY
RVAGSRGSLL YFILNDLNKI HPMYQFSLKA FGTVFELALQ KADPADTLKQ RLMNLIDCIT
FSVFQYTSRG LFESDKIIFM TQMTFQILLA SNDMALNELD FLLRFPVLPV SSPVDFLSSI
SWGGVKTLSA MEEFKNLDRD IEGSSKRWKK FVESETPEQE KFPQEWKNKT SLQKLCMMRT
LRPDRMTYTI KMYVEEKLGK KFVDIRATEF SKSYEESTPS TPIFFILSPG VDPLKDVEKL
GKVLGFTFDN KNFHNISLGQ GQEIVAENAM DTAAAEGHWV ILQNVHLVAR WLPSLEKKLE
QYSNESHPAY RVFISAEAAS SRESHIMPQG ILESAIKITN EPPTGMFANL HKALDIFSQD
TLDMCAKEME FKSILFALCY FHAVVSERRK FGPQGWNRMY PFNFGDLNIS VSVLYNYLEA
NSKVPWEDLR YLFGEIMYGG HITDDWDRRL CKTYLEEYMN PFMLDGELYL APGFPNPPNL
DYRGYHNYID EMLPNENPIL YGLHSNAEID ILSQTSEALF RSVFELQPRD AGFGATGGVS
REEKIKGILD DIKDKLPEQF LMQEIMSKVP PEERTPYVVV AFQECERMNI LTTEIKRSLI
ELNLGLKGEL TITADMENLS NSLYMDIVPE TWALRAYPSL YSLTPWYADL LLRIRELEMW
TSTFAIAGAV WLAGFFNPQS FLTAIMQQMA RKNEWPLDKM CLQCDVLKKS REEIGGAPRE
GAYVCGLFME GARWDVQSGM IAEAKLKELA PAMPVIYIKA IPVDRQETKN IYECPVYKTK
QRGQTFVWKF NLENERQAFK MDPGWCRLAA SNLRVRVYFE KIVTN
//
