ID T1F5Z4_HELRO Unreviewed; 807 AA.
AC T1F5Z4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Kazal-like domain-containing protein {ECO:0000259|PROSITE:PS51465};
GN Name=20204243 {ECO:0000313|EnsemblMetazoa:HelroP172826};
GN ORFNames=HELRODRAFT_172826 {ECO:0000313|EMBL:ESO04434.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP172826, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO04434.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP172826}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657}.
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DR EMBL; AMQM01004371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096502; ESO04434.1; -; Genomic_DNA.
DR RefSeq; XP_009017703.1; XM_009019455.1.
DR AlphaFoldDB; T1F5Z4; -.
DR EnsemblMetazoa; HelroT172826; HelroP172826; HelroG172826.
DR GeneID; 20204243; -.
DR KEGG; hro:HELRODRAFT_172826; -.
DR CTD; 20204243; -.
DR eggNOG; KOG3626; Eukaryota.
DR HOGENOM; CLU_349267_0_0_1; -.
DR InParanoid; T1F5Z4; -.
DR OMA; EDWIGLW; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF163; ORGANIC ANION TRANSPORTING POLYPEPTIDE 30B, ISOFORM A; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 706..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 612..669
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 359..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 88756 MW; 0B19E8AF8EB4856D CRC64;
MAKQVFTKVI KVIRIFDWFI RAGITGLLRF TLWYAIIQNT QISTHINTLA LPGPKHVITT
IEKRFDIGSF YSGLIAGSVE IGGASAAVFV SYFGSARHIP GWIGLGALLT GFGALLTIAI
CITQQPHHYH LNRINTNSLT NSSHNYYNNH HLQLQHHNPS HPFDTRYAPS ISVGAYYPKP
DDFPDGPPCS DKSADNYRYV LILIVAQLMI GIGGSPLYTL GTTYIDNHVS TRKAPTYIAF
IYACGVFGPI LGYGLGALML LYYVDLLRYD TTTLNLTPSN SKWVGAWWGG FMLIGALLLL
VSVPFYTFPK ILVKEIRQLA REDRQKFFSL CDVFTASREH HQQQQQQQQQ QHSNTKLLEG
DVNNKNNNNS NNNNNNNDDN ANSSNNNNNN NNNNKAGGNG VGAESGKLCR RQNCLPVYHL
TFKLSFHKSC SIQTSTPDDA HFLCTHKHRI IRACLLVSDR QHSKQIFHLP CTKLSATQST
WSPVWGSVAK CPSSVASYSF CPSGVAVPGA VIGILMGGHC LRHCQLTSRG ATQLVLALNS
IALAGFGLFF VLGCSNLKIA GITVSYDNYS HYNDLNNYIP LSSNPFFTNN NNVHNNIHNN
TNNNNNNYYN KFNLTSMCNK NCNCDDNSME FVCGDNGVIY FSPCYAGCVT AAVGNGGKEQ
NYSDCSCVIL PSSLSSSPQS PTTGSVHLTS LAEAGMGECV GKCETLVPFM VMLFFMTFVV
TGTQMPLVMV TIRSVCEQEK ALALGVQYVM LRLLAYIPAP LIYGSQIDQT CVHWARVCEV
EGNCLVYDLA CASCINSSPQ CFTLPTG
//
