ID T1FPL8_HELRO Unreviewed; 1055 AA.
AC T1FPL8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=20210765 {ECO:0000313|EnsemblMetazoa:HelroP188082};
GN ORFNames=HELRODRAFT_188082 {ECO:0000313|EMBL:ESO13044.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP188082, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO13044.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP188082}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AMQM01000289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO13044.1; -; Genomic_DNA.
DR RefSeq; XP_009009764.1; XM_009011516.1.
DR AlphaFoldDB; T1FPL8; -.
DR STRING; 6412.T1FPL8; -.
DR EnsemblMetazoa; HelroT188082; HelroP188082; HelroG188082.
DR GeneID; 20210765; -.
DR KEGG; hro:HELRODRAFT_188082; -.
DR CTD; 20210765; -.
DR eggNOG; KOG0924; Eukaryota.
DR HOGENOM; CLU_001832_6_2_1; -.
DR InParanoid; T1FPL8; -.
DR OMA; SASPWDY; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0034458; F:3'-5' RNA helicase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 530..788
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|SMART:SM00487"
FT DOMAIN 749..839
FT /note="Helicase-associated"
FT /evidence="ECO:0000259|SMART:SM00847"
FT REGION 55..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 989..1020
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 55..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 120231 MW; 889B06B6E79E3D5A CRC64;
MSDEEHDVLQ GTTGREEGGL IIMKKSSAAD EPHTFKKPTS TFFTNHSRLG LDRIAAEKKR
ESSDMDKQKL ARTYRERIDE TPTYTGGVSD AYLQKSKDRR DRDRGVYTSS KDNKEKKQNS
SSSSSSTSVT QTTSREETSK GESYRSSSRS SRRGWEEETP RNRGPMTPRL SSSKEMSSEF
NQNYPLQPLD TPSRTNWDDD DLSSSSSVVK KSSWDVPTPS LSSSSLSKKG DRQKERSRHS
DSGYVKSSFS KSSSSRKKTP APTPAYKYNN WMENGGKKVR YTPREFNKDG GGERDGDGGD
GKFNGSQDDG DRDFEKDEEL RECEIQADRL WYNMDQEQDP GCIDDTEYTR RKEQELEVKK
KKKMSAQQRQ IQKDNEMWEL NRMYRSGAVI RLDHEEDFDN QSEARVHLLV HNIVPPFLDG
RIVFTKQPEP IVPLKDPTSD MAVVSRKGSA VVLQHREQKE RKKAQKKHWE LAGSRIGDIM
GIKREEEEEK DKSDSVDYKS DQKFAEHMIN NKSEAVSEFA TSKSIKQQRE FLPIFAVRQE
LLKIVRENSV VVIVGETGSG KTTQLTQYLH EDGYTDYGMV GCTQPRRVAA MSVAKRVSEE
MGVPLGEDVG YAIRFEDCTN ETTTSSSLRH HYDAIYNDVI AGDMLIFMPG QEDIEVTCEL
IAGMDALQIF PISQANANQR SGRAGRTGPG MCYRLYTSRQ YKEDLMTVTV PEIQRTNLAN
VVLLLKSLGV QDLLQFHFMD PPPEDNIMNS MYQLWVLGAL DNTGSLTPLG RNMEEFPLDP
ALSKMLIVST EMGCSQEILT IVSMLSIPAI FFRPKGREED SDQAREKFQV PESDHLTLLN
VYNQWTKNNH SATWCTKHFI HVKSMKKVRE VRQQLKDIME QHKMALISCS SEWDIVRKCI
CSSYFQQAAR IKGLGEYVSL RTGMPCHLHP TSALFGMGYT PDYIVYHELV MTSKEYMQCV
TAVDGQWLAE LGPMFYSVKD SNKSRTERRR MAEDHMNDME DEMKRAQDQL TARREEVERS
LALNFKTTPI ITPGKRDSAT PLINPLTKKR GRFGL
//
