ID T1FR28_HELRO Unreviewed; 546 AA.
AC T1FR28;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=C-type lectin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20211275 {ECO:0000313|EnsemblMetazoa:HelroP189456};
GN ORFNames=HELRODRAFT_189456 {ECO:0000313|EMBL:ESN94635.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP189456, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN94635.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP189456}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01001689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097571; ESN94635.1; -; Genomic_DNA.
DR RefSeq; XP_009027677.1; XM_009029429.1.
DR AlphaFoldDB; T1FR28; -.
DR STRING; 6412.T1FR28; -.
DR EnsemblMetazoa; HelroT189456; HelroP189456; HelroG189456.
DR GeneID; 20211275; -.
DR KEGG; hro:HELRODRAFT_189456; -.
DR CTD; 20211275; -.
DR HOGENOM; CLU_499019_0_0_1; -.
DR InParanoid; T1FR28; -.
DR OrthoDB; 2953303at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR CDD; cd00037; CLECT; 2.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 3.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR22801:SF53; 27 KDA PRIMARY MESENCHYME-SPECIFIC SPICULE PROTEIN; 1.
DR PANTHER; PTHR22801; LITHOSTATHINE; 1.
DR Pfam; PF00059; Lectin_C; 2.
DR Pfam; PF01822; WSC; 1.
DR SMART; SM00034; CLECT; 2.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 3.
DR PROSITE; PS51212; WSC; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..546
FT /note="C-type lectin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010980909"
FT TRANSMEM 452..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..161
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 106..198
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 201..247
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 277..396
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT REGION 516..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 546 AA; 60104 MW; A5B3F69995076E99 CRC64;
MFHQIRDIVI FCLFFLSSSR AVFEITDCHK TAKRGDGLVC YKIFKTKNNF ESSVGVCDNN
NMKLATVGSD DEYAAVMELL RSSRDDDVWI GLKQFQTPWK WSDGSELKEQ GCFLSVSTTN
HDTRLMATKT GDNSALSCST ICSNNKYNYT GLRNTVECYC GDSFGVETQN GAQCDMPCPG
SSTENCGGLN SERIVNMNGL YSNWLNGQPN NGSSESPENQ ACATIVKDQN GGWGDVNCMT
SLRAVCEIGL SSSFPTCDNA TQEEVHKLSY KDASNQDTTT CIYISSRYEN YLNAIQTCNN
VNGNLIKITS QSHNDALFNV LNNFVKDGST EFWIGLSRIN FRWTTGDILS YTKFTSLSYN
KKELCAIVRT NPLNDNNEPY IWSLDDCASS KVSLCQSTNA TYIFKPTYFM PTTTTTTLLP
TKSIVPGQST TLPQVNITVP DASFVAINNN KVMYAAIGGS IGGVVLVVIV TIVIVVVICK
KKHKMPAMKA DVERTKSVFV EPTYFFGASI ENETTLPSSE TKIEDTSATD PNNQPDLVIS
SSPPPY
//
