ID T1FRB7_HELRO Unreviewed; 347 AA.
AC T1FRB7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=HMG box domain-containing protein {ECO:0000259|PROSITE:PS50118};
GN Name=20211364 {ECO:0000313|EnsemblMetazoa:HelroP189739};
GN ORFNames=HELRODRAFT_189739 {ECO:0000313|EMBL:ESN91613.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP189739, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN91613.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP189739}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01002141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097700; ESN91613.1; -; Genomic_DNA.
DR RefSeq; XP_009030443.1; XM_009032195.1.
DR AlphaFoldDB; T1FRB7; -.
DR STRING; 6412.T1FRB7; -.
DR EnsemblMetazoa; HelroT189739; HelroP189739; HelroG189739.
DR GeneID; 20211364; -.
DR KEGG; hro:HELRODRAFT_189739; -.
DR CTD; 20211364; -.
DR eggNOG; KOG0381; Eukaryota.
DR HOGENOM; CLU_060006_0_0_1; -.
DR InParanoid; T1FRB7; -.
DR OMA; DQQNNAM; -.
DR OrthoDB; 37141at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR46040; HIGH MOBILITY GROUP PROTEIN 2; 1.
DR PANTHER; PTHR46040:SF3; HIGH MOBILITY GROUP PROTEIN 2; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 50..118
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 50..118
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 248..303
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 144..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 347 AA; 40074 MW; B5617982C63C4412 CRC64;
MEEEEQIMDA SQDVEIIEDG SATAEDPSEK SKSSWSRNRR RKKPKDINAP RFPLTGYVRF
MNSVRVKIRS ENPGLPFQAL SRLMANEWAN LPANEKQRYL DEAEKDKERY TKELDSYHKT
DAYQLYLKKQ QQKKEEKELM NKLHNNNHNN SSNNNSNSSS NNNNIIQINL LHPNLSQNAH
VANNANNVNS SPHNNSSNNN NSTNNNNNIL NIQQQHQLHH HLNSAKDDEY SGGFFDIPIF
TEEFLDHNKA RESELRTLRK QSTEMEEQNA ILSKHVDSMK EEVEKLQVDV AQQRLNNEAL
KQHLLLLRTT LVQKFAGLPL PGTKSGPKLE TIDFYMSKLY ALCKEHN
//
