ID T1FSZ8_HELRO Unreviewed; 1071 AA.
AC T1FSZ8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=Transient receptor ion channel domain-containing protein {ECO:0000259|SMART:SM01420};
GN Name=20211945 {ECO:0000313|EnsemblMetazoa:HelroP191443};
GN ORFNames=HELRODRAFT_191443 {ECO:0000313|EMBL:ESO05324.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP191443, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO05324.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP191443}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01003916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096365; ESO05324.1; -; Genomic_DNA.
DR RefSeq; XP_009016639.1; XM_009018391.1.
DR AlphaFoldDB; T1FSZ8; -.
DR STRING; 6412.T1FSZ8; -.
DR EnsemblMetazoa; HelroT191443; HelroP191443; HelroG191443.
DR GeneID; 20211945; -.
DR KEGG; hro:HELRODRAFT_191443; -.
DR CTD; 20211945; -.
DR eggNOG; KOG3609; Eukaryota.
DR HOGENOM; CLU_005716_4_2_1; -.
DR InParanoid; T1FSZ8; -.
DR OMA; QNPRGEW; -.
DR OrthoDB; 2997114at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF54; TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 757..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 205..267
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 916..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1071 AA; 124112 MW; 32E9FA17410A916A CRC64;
MAHFNPNAED ELLTDEERVY LLAASQGDMA IVRQSVVGEI DVDEKLGSSD DLGKNEKEFI
KFVNNKRSVK GLKKRNLDVN CVDYMGRSAL HFAVDGENIE MIDFLMEFLS LELIDEALLH
AVSKDLAKIV RQIIEHPTYE SRNTNYPLRK FHNSFKKLHL RAEKSGQFSP DVSPLILAAH
RNNHEIIQLF LSKQQTIAKP HSISCHCCDC TAKQNCDSLK RSISRLNAYK ALASPAYMAL
SSQDPIMTTF QLRQEMKKLA QVEKEFKNEY MGLVEQCMNF ACELMDLCRG TQEVEAVLNE
GCDDRGDPLI RLKMAVEYEE KKFVAHANCQ QHLTTIWYGS DMGFLQSMEN WKKVIFLCTL
IPIVPFACLL YIISPNSRQL LKQDEYPDLT SCIKLCSLIQ LSKMLRCPAT KFLTHTLSHA
CFLVLLAVAT FRLEERNPYN LSNITDSQCF RHHRATNWNK SKFITQNKCN HSSRYHQTFS
KALRNVSFHY FVDSRHMNQS MKNPVINVDV NGLLWIECKQ LHHRGIRVYM LDYYNWIDFF
ILSLYLGSYV LRFAVDKWMK EADHFFNGTT KAREALNRHD CKRFHQIKKE IYEGNKTSMS
YFMKASRFDW RPDDPEIVSD VLFAAANVLS IARTTSMMPA FEVLGPLQIS LGRMLGDISR
FLVLFTLVLF AFMVGLHNLY WYYGFQTYVG KEGDNKIHYS TVAFQGLPRT LQSLFWSMFG
LVPVESVEVK YPGKWESSEY HNNFPGGNHT TSLVEQVGMY LFALYHVTVI IVLTNMLIAM
MSHSFEAIQG DCDVEWKFAR TKLWMNYIDH GSTLPVPFNV VPTIKTLKYF IGWSSRIKAY
LLDYRCRKKK NLEVERVNDS CTSDDDSTGI YLNTYSDILQ RLVRRYLFKL ERMKEENKEV
SAVICDPVSQ FTNEAYTGQL KDPDKDGLLP GNKVMRLSSS TSKSSDRVTN NAPIGRRLSL
KPSQMQNKQR QNKTRQNKLG RWRQLYTNSS FRTNQQMHVH VGFVQLVTLP QLDSVQKILK
NLDVRFQRLH ERAKNEQRTR QDIKHILTVI LENQKAVRSY NIVLPSFKRE I
//
