ID T1FT66_HELRO Unreviewed; 659 AA.
AC T1FT66;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein {ECO:0000259|Pfam:PF07699};
GN Name=20212013 {ECO:0000313|EnsemblMetazoa:HelroP191657};
GN ORFNames=HELRODRAFT_191657 {ECO:0000313|EMBL:ESO04625.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP191657, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO04625.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP191657}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01004147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096457; ESO04625.1; -; Genomic_DNA.
DR RefSeq; XP_009017204.1; XM_009018956.1.
DR AlphaFoldDB; T1FT66; -.
DR EnsemblMetazoa; HelroT191657; HelroP191657; HelroG191657.
DR GeneID; 20212013; -.
DR KEGG; hro:HELRODRAFT_191657; -.
DR CTD; 20212013; -.
DR HOGENOM; CLU_416372_0_0_1; -.
DR InParanoid; T1FT66; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR42264; EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR42264:SF3; F-BOX DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 377..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 328..367
FT /note="Tyrosine-protein kinase ephrin type A/B receptor-
FT like"
FT /evidence="ECO:0000259|Pfam:PF07699"
FT REGION 230..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 73804 MW; 9265A14B9B38A210 CRC64;
MSYFMNNRSQ TFESHESNSL GKAWYVREGF PVVINCFAGL IDEPGAYLKY RGAIFEWGYK
GKKDPILETG RTLYGNGTVE YSSVSKLDSG TLYCTAEKLD GTSKDTFTHS LIVYTIAQFF
LTYPFVYTVP ICDSRANNKQ SDIMKRLCAS YGPSRDDCPF SARMECFSKI NKHGASDGYR
LRIHIEQRLE RNFRAPNCDA KCIKKAIYNQ LTTSGDDIVK KVIDYELSNN NINNNNNNNN
NSNNEASNKN RNQNNNNNNN NNNNDNNKTI SQSIYIGYVF DSEELMHKST LIRCPNGHQI
YMQVLCVPCF PGFFAFYDSR FTDKNFPNEC EPCDYGFYQE QFSMDTCYKC PDFGITVKRG
SSDSKDCISR HLSSIELYLA AAAVLVLGLS ISLLCMAQFG INVLRERNKE KLLAAGVDIR
SGYPGLGFRA PLQPPQPQQA AAFLATNNSA ISPLANNKSI KTSGRPTAIN STKLTSQPTS
ELTSELQKNY SNNLKRRHLV DKNVSTTPRP PFKVCEQVCK KKSIKESIDN GHSSSNSRQS
RSILTDHPSK NEYSLIRQKE HESFVVFDRS SGTTKPGNDG YSNSNQNESN ENSISDEEEN
VQLLSHPNST SVSLGSLELS HSKEEDKVSA SGEGEDSEGC ERSASCSIHL ENYETPSEY
//
