GenomeNet

Database: UniProt
Entry: T1FTG3_HELRO
LinkDB: T1FTG3_HELRO
Original site: T1FTG3_HELRO 
ID   T1FTG3_HELRO            Unreviewed;       719 AA.
AC   T1FTG3;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   Name=20212110 {ECO:0000313|EnsemblMetazoa:HelroP191960};
GN   ORFNames=HELRODRAFT_191960 {ECO:0000313|EMBL:ESO03799.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP191960, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA   Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA   Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA   Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA   Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESO03799.1, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP191960}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       DDX15/PRP43 sub-subfamily. {ECO:0000256|ARBA:ARBA00024333}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AMQM01004561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB096590; ESO03799.1; -; Genomic_DNA.
DR   RefSeq; XP_009018356.1; XM_009020108.1.
DR   AlphaFoldDB; T1FTG3; -.
DR   STRING; 6412.T1FTG3; -.
DR   EnsemblMetazoa; HelroT191960; HelroP191960; HelroG191960.
DR   GeneID; 20212110; -.
DR   KEGG; hro:HELRODRAFT_191960; -.
DR   CTD; 20212110; -.
DR   eggNOG; KOG0925; Eukaryota.
DR   HOGENOM; CLU_001832_5_11_1; -.
DR   InParanoid; T1FTG3; -.
DR   OMA; MKVYPLY; -.
DR   OrthoDB; 5488182at2759; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd17973; DEXHc_DHX15; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR044756; DHX15_DEXHc.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF109; DEAH-BOX HELICASE 15, ISOFORM A; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT   DOMAIN          75..240
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          265..445
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   719 AA;  81976 MW;  CD93D41020E4AB2E CRC64;
     MSKRHRIDVG DSSSSSKKRS DDDSKPVVSN VASFPTVKSI LTQNPFTGLP FTPKYWELYK
     KRTNLPVWEY KEKFIDILNK NQCLVLVGET GSGKTTQIPQ WCLEWVRARY TKKGVACTQP
     RRVAAMSVAA RVAEEMDVGL GQEVGYNIRF EDCTSSKTIL KYMTDGMLLR EAMSDPLLEA
     YGVVMLDEAH ERTLATDILM GLLKEVSRQR ADLKIVVMSA TLDAGKFQQY FDNAPLMSVP
     GRTHPVEIFY TPEPERDYLE AAIRTVIQIH MCEESEGDIL LFLTGQEEID EACKRIQREI
     DNLGPEVGEL KCIPLYSTLP PNLQQRIFEP PPPKRPNGAI GRKVVVSTNI AETSLTIDGV
     VFVIDPGFAK QKVYNPRIRV ESLLVTAISK ASAQQRAGRA GRTRPGKCFR LYTEKAYKNE
     MQDNTYPEIL RSNLSAVVLQ LKKLGIDDLV HFDFMDPPAP ETLMRALELL NYLAAIDDDG
     ELTELGSMMA EFPLDPQLAK MVIASCDYNC SNEILSITAM LSVPQCFVRP TEVRKQADEA
     KMRFAHIDGD HLTLLNVYHA FKQNHDEAQW CYDNFINYRS LKSADNVRTQ LARIMDRFNL
     RRSSTEFSSR DYYINIRKAL VSGYFMQVAH LERTGHYLTV KDNQIVQLHP STCLDHKPEW
     VLYNEFVLTT KNYIRTVTDI KAEWLIQITP QYYDMSNFPQ CEAKRVLEKL IAKMDSKQQ
//
DBGET integrated database retrieval system