ID T1FTG3_HELRO Unreviewed; 719 AA.
AC T1FTG3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=20212110 {ECO:0000313|EnsemblMetazoa:HelroP191960};
GN ORFNames=HELRODRAFT_191960 {ECO:0000313|EMBL:ESO03799.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP191960, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO03799.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP191960}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX15/PRP43 sub-subfamily. {ECO:0000256|ARBA:ARBA00024333}.
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DR EMBL; AMQM01004561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096590; ESO03799.1; -; Genomic_DNA.
DR RefSeq; XP_009018356.1; XM_009020108.1.
DR AlphaFoldDB; T1FTG3; -.
DR STRING; 6412.T1FTG3; -.
DR EnsemblMetazoa; HelroT191960; HelroP191960; HelroG191960.
DR GeneID; 20212110; -.
DR KEGG; hro:HELRODRAFT_191960; -.
DR CTD; 20212110; -.
DR eggNOG; KOG0925; Eukaryota.
DR HOGENOM; CLU_001832_5_11_1; -.
DR InParanoid; T1FTG3; -.
DR OMA; MKVYPLY; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd17973; DEXHc_DHX15; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044756; DHX15_DEXHc.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF109; DEAH-BOX HELICASE 15, ISOFORM A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 75..240
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 265..445
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 81976 MW; CD93D41020E4AB2E CRC64;
MSKRHRIDVG DSSSSSKKRS DDDSKPVVSN VASFPTVKSI LTQNPFTGLP FTPKYWELYK
KRTNLPVWEY KEKFIDILNK NQCLVLVGET GSGKTTQIPQ WCLEWVRARY TKKGVACTQP
RRVAAMSVAA RVAEEMDVGL GQEVGYNIRF EDCTSSKTIL KYMTDGMLLR EAMSDPLLEA
YGVVMLDEAH ERTLATDILM GLLKEVSRQR ADLKIVVMSA TLDAGKFQQY FDNAPLMSVP
GRTHPVEIFY TPEPERDYLE AAIRTVIQIH MCEESEGDIL LFLTGQEEID EACKRIQREI
DNLGPEVGEL KCIPLYSTLP PNLQQRIFEP PPPKRPNGAI GRKVVVSTNI AETSLTIDGV
VFVIDPGFAK QKVYNPRIRV ESLLVTAISK ASAQQRAGRA GRTRPGKCFR LYTEKAYKNE
MQDNTYPEIL RSNLSAVVLQ LKKLGIDDLV HFDFMDPPAP ETLMRALELL NYLAAIDDDG
ELTELGSMMA EFPLDPQLAK MVIASCDYNC SNEILSITAM LSVPQCFVRP TEVRKQADEA
KMRFAHIDGD HLTLLNVYHA FKQNHDEAQW CYDNFINYRS LKSADNVRTQ LARIMDRFNL
RRSSTEFSSR DYYINIRKAL VSGYFMQVAH LERTGHYLTV KDNQIVQLHP STCLDHKPEW
VLYNEFVLTT KNYIRTVTDI KAEWLIQITP QYYDMSNFPQ CEAKRVLEKL IAKMDSKQQ
//