ID T1FTI0_HELRO Unreviewed; 1009 AA.
AC T1FTI0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
GN Name=20212127 {ECO:0000313|EnsemblMetazoa:HelroP192002};
GN ORFNames=HELRODRAFT_192002 {ECO:0000313|EMBL:ESO03340.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP192002, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO03340.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP192002}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center {ECO:0000256|RuleBase:RU363050}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
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DR EMBL; AMQM01004625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096633; ESO03340.1; -; Genomic_DNA.
DR RefSeq; XP_009018488.1; XM_009020240.1.
DR AlphaFoldDB; T1FTI0; -.
DR STRING; 6412.T1FTI0; -.
DR EnsemblMetazoa; HelroT192002; HelroP192002; HelroG192002.
DR GeneID; 20212127; -.
DR KEGG; hro:HELRODRAFT_192002; -.
DR CTD; 20212127; -.
DR eggNOG; KOG4344; Eukaryota.
DR HOGENOM; CLU_011574_0_0_1; -.
DR InParanoid; T1FTI0; -.
DR OMA; ILRFWLM; -.
DR OrthoDB; 3678492at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000923; C:equatorial microtubule organizing center; IBA:GO_Central.
DR GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; IBA:GO_Central.
DR CDD; cd22572; GCP5_NTD; 1.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF33; GAMMA-TUBULIN COMPLEX COMPONENT 5; 1.
DR Pfam; PF20685; GCP5-Mod21_C; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|RuleBase:RU363050};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 694..995
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
FT REGION 474..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..508
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 117400 MW; A1CB81DF31B8258B CRC64;
MARWIAIEDD VKSLINSIAS GQVNTENFDL CLNFALSNFK FHKFLETDES KVERSLDGIY
KKFVIHGLTT KADYFKKVTA RYLSMPLYDG KEKSAAQYSI LSVLLLLASS PTSVYALFIP
NAIQKQKLSK SKSESEFKGD VFKFCKIWLE KNVTHPYWKS GRDDVWRNYI AKYGTPDSKV
LKNRSRFFSI WNAYIQEESS LVSHTMKQYL LSEYQVIRET LWMLSGNSQQ LFVFKWNGCR
FKRNSDVIIA HLAEKSLHKI LNDLSTYGSM IVHLRAYCDA IFTNRLDPNH TNPLDSSYTN
RSDAIFINQS DLAVSNCNQN TTGNNINNKT DFKLSMVSMK ERNLYSLVPA TQTHQALAEV
TAKWLRGFQS VLVVLEKETL MQEGTTTLVN VAFRLMKHLK QISIIYHFLF EGVMNLVIDF
WLAISRPTID IIDVWFNKGV LYDIYGEFFI RKGPKWSAMD ETFWDECLIL DDDDDDDADD
DNDDDEGSHG NSSNPLHHHH HQRHLSYQRE QRTKRQQLIQ EPQIHWRHQL QQQQLLLQQL
QPQQHQQQHQ KQQQQQTYDS SFKFAAKSYL LDCDDFLRKI VMNSFQFSDD EDDVNDDAKK
NNNINNNINN IDNINNNNKL DIGNIEIKLN KTIYQLIEHR YKSVSNKLIL TLKHNFKLDS
HFKAIRNCYL MESGRVIWTV SRVANKTNNN NNCDHNNYDN NNNSDDDDDD YSSIKYFETM
HLKYSLPWPC CLIINSDDVT AYNRIFQFIM QIKWALYSLQ KLRFGDLPKN FENISTSSLN
HVTSASDRNA TTATTSATTT TTSSPSHSMF IFKMRLLHFA SNIHDYIMTR ILHLVGLEFQ
CHFDQSNDFN HFISCHRQYV KTLLERCMLH KKVEFIKEMI MKILKIAIRF SQIWNSVIHI
NNNNNNNNNN NNNSNDILDN SSGSKFAAKN MHRDSSDDDI KVDDTSQGVK YVDFSEVESL
ECEFARCVQF LSSMINKVVT RGSFPHLESL AFTLSTCVDL QHNRGQQQQ
//
