ID T1FU88_HELRO Unreviewed; 493 AA.
AC T1FU88;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Tubulin delta chain {ECO:0000256|ARBA:ARBA00014184};
DE AltName: Full=Delta-tubulin {ECO:0000256|ARBA:ARBA00030594};
GN Name=20212384 {ECO:0000313|EnsemblMetazoa:HelroP192737};
GN ORFNames=HELRODRAFT_192737 {ECO:0000313|EMBL:ESO00110.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP192737, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO00110.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP192737}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000256|ARBA:ARBA00004114}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; AMQM01005663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097026; ESO00110.1; -; Genomic_DNA.
DR RefSeq; XP_009021884.1; XM_009023636.1.
DR AlphaFoldDB; T1FU88; -.
DR STRING; 6412.T1FU88; -.
DR EnsemblMetazoa; HelroT192737; HelroP192737; HelroG192737.
DR GeneID; 20212384; -.
DR KEGG; hro:HELRODRAFT_192737; -.
DR CTD; 20212384; -.
DR eggNOG; KOG1374; Eukaryota.
DR HOGENOM; CLU_015718_1_0_1; -.
DR InParanoid; T1FU88; -.
DR OrthoDB; 5476360at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR CDD; cd02189; delta_zeta_tubulin-like; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002967; Delta_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF4; TUBULIN DELTA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR PRINTS; PR01224; DELTATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 67..275
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
SQ SEQUENCE 493 AA; 56041 MW; 00050DECF984782B CRC64;
MSVVTIQIGQ YGNQIGHEFF STLAKELFCE SENCNDNKNK DTENKTAQNI KLNQNRILKD
SFEEDGLDIF FQNSAKNRNS YVARCVLIDT EAKVVDRVLS SSLSSISVSS DMLNKTWSYN
KKFKISHKYG SGNNWAQGFY SFGAKVVDSL DELIRHQVEK CDRLGGFLSM MSLAGGTGSG
LGSYLIRHLR EYYDKSAIIS QVIWPYRSGE IAVQSYNSIL SLAHIYEAVD SIVAFSNDGM
QKTCQLQLGL TKVSLSDINR LISMNLVHAF LPSFTDGLIG SYDCLGDYIN HLTPHPDLKM
TSLMTSPMVS DLIRPFTVYS WASTLKELGR LYNLQATPGN QFDPEWQLKY DGTLNNSKAF
AHILINRGFE CSLSNNHNTN SHNKYNSKRN NNNNKVAVKN EFLKLKSSYP IYQPNGFLFK
HHQRPIFNQH MSSLLAYNDV NQMYIVDEAL EKTCKLFENR TYVHQYERHG CAVDDFVDSI
LMVQQLLSNY ARL
//
