ID T1FV10_HELRO Unreviewed; 764 AA.
AC T1FV10;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=B-related factor 1 {ECO:0000256|ARBA:ARBA00031009};
GN Name=20212656 {ECO:0000313|EnsemblMetazoa:HelroP193467};
GN ORFNames=HELRODRAFT_193467 {ECO:0000313|EMBL:ESN96004.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP193467, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96004.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP193467}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TFIIB family.
CC {ECO:0000256|ARBA:ARBA00010857}.
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DR EMBL; AMQM01006626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097496; ESN96004.1; -; Genomic_DNA.
DR RefSeq; XP_009026029.1; XM_009027781.1.
DR AlphaFoldDB; T1FV10; -.
DR STRING; 6412.T1FV10; -.
DR EnsemblMetazoa; HelroT193467; HelroP193467; HelroG193467.
DR GeneID; 20212656; -.
DR KEGG; hro:HELRODRAFT_193467; -.
DR CTD; 20212656; -.
DR eggNOG; KOG1598; Eukaryota.
DR HOGENOM; CLU_010293_2_1_1; -.
DR InParanoid; T1FV10; -.
DR OMA; AEPPCKV; -.
DR OrthoDB; 5483352at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000126; C:transcription factor TFIIIB complex; IBA:GO_Central.
DR GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0001006; F:RNA polymerase III type 3 promoter sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IBA:GO_Central.
DR GO; GO:0006383; P:transcription by RNA polymerase III; IBA:GO_Central.
DR GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR CDD; cd20553; CYCLIN_TFIIIB90_rpt1; 1.
DR CDD; cd20554; CYCLIN_TFIIIB90_rpt2; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR Gene3D; 1.20.5.650; Single helix bin; 1.
DR InterPro; IPR011665; BRF1_TBP-bd_dom.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR000812; TFIIB.
DR InterPro; IPR013150; TFIIB_cyclin.
DR InterPro; IPR013137; Znf_TFIIB.
DR PANTHER; PTHR11618:SF4; TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT; 1.
DR PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1.
DR Pfam; PF07741; BRF1; 1.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF00382; TFIIB; 2.
DR PRINTS; PR00685; TIFACTORIIB.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51134; ZF_TFIIB; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00469};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00469};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT DOMAIN 1..32
FT /note="TFIIB-type"
FT /evidence="ECO:0000259|PROSITE:PS51134"
FT REGION 470..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 85860 MW; 0F1B6C74C31EEB55 CRC64;
MSSVCKNCGS TDIDRDQTRG NAVCTQCGVV VEDQIIVSEI QFQENATGGA SVIGQFVSFE
SRHNSAGGSR NYGRDSRHVT LQNGKNRIQK LASNLNLSSH CADMAYNFFK LAVSKSLTKG
RRSIHVAAAC LYIACRTEKK PLMLLDFSDK LGTDVYTLGH TYLQLSKDLY IAIPAIVCNI
ESMLSSCNLP EKTLEVAGLL TRLVGRMSRD WMVQGRRPSG ICGAALLVAA RIFDFNRTIK
DMMKVVRIGE QTIKKRLLEF EKTPSSKLTV EEFHTINLEE TMDPPCFTEG KKKAKLLELE
ENGVLPELLE EAEELRIQLD AAIQEMISRK NIKYRKFKNS FHKGAEDDVD VAYDDDDSKA
VDWCTDAPST NELDEELAHY QNLLGDDTAT PATTTTTAAT TATNESFDIV DQDIDSLMAA
ELDQILGNNY SSNINDSSSS YNNVETNDAR NNLQYHTSLG LKESIDECLQ RSKKDDDNDE
GGADSKNNIE LENNGELDLT GLDDDELDEM ILNSDEVRIK TAIWMRENAD FLKEMKEKEE
RKAKELLENP EPLKKRRKSR KCKSKVQALT AKEAIEKIVH EKKLSNKINY DVLMDFNLCK
MERKPNVNAM DAGRGDDGVR LQSENVIVLD NDDADCACKA KKLKLEETKK VDEAPAKKDG
GSDLPVQEFK SNNISDGEMD NDEFFFDNEI EHATSEQQNA CKPLWFTMWR TMMTTTTPIN
STLSITPSLF LSFYLYSLLF HSTLLSLKFP CVHFSVNFLL SNEF
//
