ID T1FV96_HELRO Unreviewed; 279 AA.
AC T1FV96;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Pirin N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20212742 {ECO:0000313|EnsemblMetazoa:HelroP193693};
GN ORFNames=HELRODRAFT_193693 {ECO:0000313|EMBL:ESN94993.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP193693, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN94993.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP193693}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the pirin family.
CC {ECO:0000256|ARBA:ARBA00008416, ECO:0000256|RuleBase:RU003457}.
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DR EMBL; AMQM01007008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01007009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097552; ESN94993.1; -; Genomic_DNA.
DR RefSeq; XP_009026890.1; XM_009028642.1.
DR AlphaFoldDB; T1FV96; -.
DR STRING; 6412.T1FV96; -.
DR EnsemblMetazoa; HelroT193693; HelroP193693; HelroG193693.
DR GeneID; 20212742; -.
DR KEGG; hro:HELRODRAFT_193693; -.
DR CTD; 20212742; -.
DR eggNOG; ENOG502QQ5A; Eukaryota.
DR HOGENOM; CLU_045717_5_2_1; -.
DR InParanoid; T1FV96; -.
DR OMA; TPWHPHR; -.
DR OrthoDB; 47035at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008127; F:quercetin 2,3-dioxygenase activity; IBA:GO_Central.
DR CDD; cd02247; cupin_pirin_C; 1.
DR CDD; cd02909; cupin_pirin_N; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR InterPro; IPR012093; Pirin.
DR InterPro; IPR008778; Pirin_C_dom.
DR InterPro; IPR003829; Pirin_N_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR13903:SF8; PIRIN; 1.
DR PANTHER; PTHR13903; PIRIN-RELATED; 1.
DR Pfam; PF02678; Pirin; 1.
DR Pfam; PF05726; Pirin_C; 1.
DR PIRSF; PIRSF006232; Pirin; 2.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 20..115
FT /note="Pirin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02678"
FT DOMAIN 146..227
FT /note="Pirin C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05726"
FT REGION 240..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 279 AA; 31095 MW; BFBD00085BE7A472 CRC64;
MMKRVVKKVL SHWENEGVGA RVRRSIGRPE LKNLDPFLLL DELSGRPPAG FPDHPHRGFE
TVSYLLSGNI RHEDFMGNKG DLGAGDVQWM TAGRGVVHSE MLHGDEVTHG LQLWVNLSKK
DKMIAPSYQE LPAEKIPTAA KDGVKVKVIA GESLEAKGED VVEEFHTAVL SEDEELLVVF
NKSDAPCHFV LISGQPIREP VFQRGPFVMN SQEEVEQAFS DYRSCSNGFE SAKTWREIKR
RELGKGRKRN GGGGDGGGDD DDDDKKGMTS SLRHHHHHR
//
