ID T1FVA2_HELRO Unreviewed; 1067 AA.
AC T1FVA2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Peptidase M16C associated domain-containing protein {ECO:0000259|SMART:SM01264};
GN Name=20212748 {ECO:0000313|EnsemblMetazoa:HelroP193706};
GN ORFNames=HELRODRAFT_193706 {ECO:0000313|EMBL:ESN95019.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP193706, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN95019.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP193706}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01007025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097552; ESN95019.1; -; Genomic_DNA.
DR RefSeq; XP_009026912.1; XM_009028664.1.
DR AlphaFoldDB; T1FVA2; -.
DR STRING; 6412.T1FVA2; -.
DR EnsemblMetazoa; HelroT193706; HelroP193706; HelroG193706.
DR GeneID; 20212748; -.
DR KEGG; hro:HELRODRAFT_193706; -.
DR CTD; 20212748; -.
DR eggNOG; KOG2019; Eukaryota.
DR HOGENOM; CLU_009165_0_0_1; -.
DR InParanoid; T1FVA2; -.
DR OMA; NYLYYIR; -.
DR OrthoDB; 5477696at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0016485; P:protein processing; IBA:GO_Central.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 2.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 487..770
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
SQ SEQUENCE 1067 AA; 119415 MW; DE9507DB7EF45EB3 CRC64;
MSSAARYFRI SNFLKRKCHA ISSSSLKSKK GNVLPETITN LKTGDQLHNY RVTAVTPVPE
LNLTAIHLIH KTGAEHLHIS RQDAENVFAV SLRTTPHDST GVPHILEHVS LCGSEKFPVR
DPFFKMLTRS TSTFMNAFTA SDWTMYPFSS QNAKDFENLL LVYLDAVFFP RLRRNDFHQE
GWRLEHENVD DKSSPIILKG VVYNEMKGVF SDPHQVYEQA LQNRLLPSGT YGVISGGDPK
HIPELTWKQL KSFHSRHYHP SNSRFFTYGD MPLDKHLFII DSVALSKFIR GPIDTVVHPE
KRWTSPLVST VQCPVDLMSP DPQADTIVSV RRGNLQESFE LSFLGNLLLQ GDKAPFYQAL
IESGLGSDYS PGTGYSNHTR DTSFSEVLST IESTIDQIIK EGFSENQIEA VMHKIQLSIK
HQTERYGLNL IMSLISEWNH GADPIQLLQI SKLVEELKHR LTIEPDYLQS LVSQYLKNNK
HKLTLISESD PSYLIGRKKE EEELLEQLVS SLSDVKKEEI YNDGLELAKL QSIPEDVSCL
PSLDISDIPK QYEKTDAGRV LVDISSKGSR SIAFNSTTAT ADECIDNYEK AVNERYRKSI
LPVQTCIQPT NGIVYLRMVS DASSLAAKLK PYLPLFCKIV TKMGAGELDY RQQGEQMDLK
TGGLEASAFL CDHPSHPDFF QCSVAFSSYC LDSNLNDMMR LWSDIFVSLS LVDRERFYTL
MSTLAAEGAS TLPSAGHRYA MIRSSSSLGH SFGLRESWAG VTQLGFIKNL VTLLSSSSPG
SEEMFDVQKV DMLLGVLKEI ADHILLSSPG RLRASINAAD SQIVDTSLKE LEKFYREVDM
FGIKNHNSKS IKDGGSVGGD TNTPSDEIRY ASESSFRPSY SRTHLEFPFQ VNFIGKSFLT
VPFAHPHYVP LQVLAKILSS KYLHREVREK GGAYGGGADA GSNCFSFYSY RDPNLTRSLE
SFSKSVDWAC GGQFKDADVG EAKLSLFSSV DKPISPGNKG TRLFMQGISE EMFEEYRRRI
FQVSKDDVVH VADKYLSEQS KASVAVIGPK NEVTSSASSG WHVVKED
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