ID T1FX70_HELRO Unreviewed; 1200 AA.
AC T1FX70;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=TRPM SLOG domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20213418 {ECO:0000313|EnsemblMetazoa:HelroP62898};
GN ORFNames=HELRODRAFT_62898 {ECO:0000313|EMBL:ESO12925.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP62898, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO12925.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP62898}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01000262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO12925.1; -; Genomic_DNA.
DR RefSeq; XP_009009645.1; XM_009011397.1.
DR AlphaFoldDB; T1FX70; -.
DR STRING; 6412.T1FX70; -.
DR EnsemblMetazoa; HelroT62898; HelroP62898; HelroG62898.
DR GeneID; 20213418; -.
DR KEGG; hro:HELRODRAFT_62898; -.
DR CTD; 20213418; -.
DR eggNOG; KOG3614; Eukaryota.
DR HOGENOM; CLU_001390_4_1_1; -.
DR InParanoid; T1FX70; -.
DR OMA; YAIAYIC; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IBA:GO_Central.
DR GO; GO:0098655; P:monoatomic cation transmembrane transport; IBA:GO_Central.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF1; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPM; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 738..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 915..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 943..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 983..1003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1060..1088
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 115..378
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 847..1090
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1200 AA; 138027 MW; 08931C4099B55BB9 CRC64;
MQINFNSKNL SLNSRFESQK NLIAFCFIEI KCCNEKSLWI ERTFKKRECI QFMPEINDYT
KCQCGKDEFS HTNSRMNEIT KSSYAVPPVW DPLTNTDLLP TDAYGTIEFR NGKSQYIRLS
NDTHPEDVLT FLHTHWRLDN AKMLISIYGD FVNYDLRPEL REVCNEGIFN AAKTTGAWVI
TDGVHLDVVK RLNESLGDTT GQSRHNIVRI GIVAWGVVHR REDLIGRNKS VPYSFSSANN
DGTVLNVNHS HYLLVDDGSV GKFGSEIILR KNLERYISQQ KIANNSNHGT PVVRLLMGGG
SNCIRSVIDC VTNKPPIPVL VIDKSGGTSD LLSFAHENIQ SDGGMSQNTR KRLQAMISNL
SRLEHSAYEN VFEELMLCVK HKKSITIFRL QNGKESLDQA LLSVLLRCQK SSLQYQLHLT
MAWNRVDVAR KHFLACAHLC KEGALDSLML EALVHDRVEF VQLLIESGLN VKMWLTIKRL
EELYNQRFDP TSTLRHLLSE QKTVTHHHHR RHPPPHHHHP FIDYVPSNYR FSLYEIGQVI
NKLMGGAFQS LYGKRKFRLL HNAAKIKSRK ISTASRTSTT STTSTNDDDY NHLLSDTFKY
PYSELMMWAV LLRRHNMARF MWRMGQESMA KCLIAGKLYS GMAREADEDE DDVGASYEID
KHHQEFVALS TELLNHYCKI DSELTKLLLT YELSNWSNQT CLSLAVADRN MNFLAHTCCQ
VLLTEMWMGG LRTRKYPSIK VIFGILCFPL IFFFNYKSIE ELEIMPQTQH QLQQLNLPNA
IIDIPSSSGK SSTAVAAAAT AALAAVGAAA AGMNSATNQD GPQLFTERLV VIRCKIIHFY
AAPITKFWMH AIGHCVFALL FFYMVIQPTP AERRTAAEWY VLAYMCALTG EKFREFVTCD
APKIRQKVFI FFNDFWNIAD ISSICLFYIG FALRFHFDST SRVFYSLTVM LCIVKFVEFF
VIGPKFGPYI TILKKMVSWK KDLLFYILVI LVSFGTFRQS LWFPEQDFKW SSVRKIFLKP
YFMLYGETYS DEIWPDCVDD VTSEEEFPCV PGRWLVPFIF AVYLAVGIIV LLSLLIAVIN
GVFMRIYAHS NTVWKFQRYN LIIKYETRPI LPAPFILINH AFITFRYLLM CCTKKQTFFD
RGLKVFLDEQ DLEKLHDFED GCIQSFHKNR ARRTTTNDKQ TDNQKALKLG ICSEFQNVET
//
