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Database: UniProt
Entry: T1FYP8_HELRO
LinkDB: T1FYP8_HELRO
Original site: T1FYP8_HELRO 
ID   T1FYP8_HELRO            Unreviewed;       805 AA.
AC   T1FYP8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   25-OCT-2017, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESN98767.1, ECO:0000313|EnsemblMetazoa:HelroP66730};
GN   Name=20213946 {ECO:0000313|EnsemblMetazoa:HelroP66730};
GN   ORFNames=HELRODRAFT_66730 {ECO:0000313|EMBL:ESN98767.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP66730, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP66730, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Simakov O., Marletaz F.,
RA   Cho S.-J., Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T.,
RA   Lv J., Arendt D., Savage R., Osoegawa K., de Jong P., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESN98767.1, ECO:0000313|EnsemblMetazoa:HelroP66730, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP66730}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
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DR   EMBL; AMQM01001052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB097143; ESN98767.1; -; Genomic_DNA.
DR   RefSeq; XP_009022460.1; XM_009024212.1.
DR   EnsemblMetazoa; HelroT66730; HelroP66730; HelroG66730.
DR   GeneID; 20213946; -.
DR   KEGG; hro:HELRODRAFT_66730; -.
DR   CTD; 20213946; -.
DR   KO; K04967; -.
DR   OMA; GFNEYVH; -.
DR   OrthoDB; EOG091G029I; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000015101};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    313    337       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    349    370       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    527    549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    632    653       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30    160       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      128    160       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   805 AA;  92274 MW;  97798E04D9474AB3 CRC64;
     MSEDGEWNSL GVGVVRKEVD LTPLEKQFLY AVERGDIPTV QKLLNDNANK LNFNSNCVDA
     LGRTALAISI EYDNIEMLDV LLKGRLDLGD SLLQAINEDN VEATQMILNH EKKLQKQDIT
     GNNSCFTPDI TPIILAAQRD NYEITKILLD RGDSISKPHD IRCSCDICVT KTAEDSLNHS
     MSRINAYRAL ASPSLIALSS KDPILTAFEL SWELRRLSKL ENELKIEYEG LAKQCQNFAV
     DLLDQVRGSK ELEVLLNYDK YAPVRDFGDR MALARLKLAI KYKQKKFVSH ANCQQLLASI
     WYEGLLGFRR RHIIFKVLLT IIVSLLFPIL SLIYIISPKS QAGQFMRRPF IKFICHSASY
     MTFLSLLILA SQRIKSIISL AKEADDKSTK MIREVRGAPP TSIEWMILAY VAEGLVWAEI
     KQLWDQGLKS YVHDMWNILD FTTNSLYIAT YTLKLVAYLK VEEEKRNNYP SAYADRKSWD
     AYDPTLISEG LFASANIFSC LKLIYIFTVN PHLGPLQISL GRMVIDILKF LFIALLVCFS
     YSCGVNQLYW YYAEVKSREC SVCEANKVNI TSLLNANINK SVLGVMSLTT KFCHNSLFEI
     IQTLYFAIYG LVELNKFELK EKHIFTQFVG KLMFGTYLSI MTVVLINMLI AMLSSSFQKI
     SDDADTEWKF ARSRLWMSYF EEGGTVPTPF NIIPTPKTFW YLGKWMFDRL CRFSTKAKTN
     KWHSLKRAVK RMQERDVVYQ SVIFDLVKRY VMKRQKKTSE GVTEDNVNEL KQDLSSFRYE
     LLDILRSNGM NVPKPSLNSS GNQCR
//
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