ID T1FZE0_HELRO Unreviewed; 505 AA.
AC T1FZE0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Matrin-type domain-containing protein {ECO:0000259|PROSITE:PS50171};
GN Name=20214188 {ECO:0000313|EnsemblMetazoa:HelroP68394};
GN ORFNames=HELRODRAFT_68394 {ECO:0000313|EMBL:ESN96303.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP68394, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96303.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP68394}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SF3A3 family.
CC {ECO:0000256|ARBA:ARBA00008776}.
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DR EMBL; AMQM01001378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097495; ESN96303.1; -; Genomic_DNA.
DR RefSeq; XP_009025223.1; XM_009026975.1.
DR AlphaFoldDB; T1FZE0; -.
DR STRING; 6412.T1FZE0; -.
DR EnsemblMetazoa; HelroT68394; HelroP68394; HelroG68394.
DR GeneID; 20214188; -.
DR KEGG; hro:HELRODRAFT_68394; -.
DR CTD; 20214188; -.
DR eggNOG; KOG2636; Eukaryota.
DR HOGENOM; CLU_027160_2_0_1; -.
DR InParanoid; T1FZE0; -.
DR OMA; GPKAFQK; -.
DR OrthoDB; 5483967at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR000690; Matrin/U1-C_Znf_C2H2.
DR InterPro; IPR025086; SDE2-like_C_dom.
DR InterPro; IPR031774; SF3A3_dom.
DR InterPro; IPR024598; SF3a60/Prp9_C.
DR InterPro; IPR021966; SF3a60_bindingd.
DR PANTHER; PTHR12786:SF2; SPLICING FACTOR 3A SUBUNIT 3; 1.
DR PANTHER; PTHR12786; SPLICING FACTOR SF3A-RELATED; 1.
DR Pfam; PF13297; SDE2_2C; 1.
DR Pfam; PF16837; SF3A3; 1.
DR Pfam; PF12108; SF3a60_bindingd; 1.
DR Pfam; PF11931; SF3a60_Prp9_C; 1.
DR PROSITE; PS50171; ZF_MATRIN; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 410..441
FT /note="Matrin-type"
FT /evidence="ECO:0000259|PROSITE:PS50171"
FT REGION 348..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..376
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 58823 MW; 71978BE5FA4F7D38 CRC64;
MADSSILELQ RRCHEERERL VDAMMKEAMF QKKSLRDQIN SDYRQKVLLE RSLENVQELK
DLYEDKDGLR KEEIAALSGP NEFTEFYNRL KSIKDFHRKH PNEICVPMSI EFDELAKIRE
NPSDEMQDLV QFTDEEGYGK YLDMHECYNK YINLKGVERV DYLTYLNVYD HFFDIPRERK
NAAYKDYLMT LLTYLESYLS RVKPMLDFNE ELSIVIEEFD KKWAEGAFPG WPKETSGALT
HSGAHLDLSA FSSWEELASL GLDRLKSALM ALGLKCGGTL EERAQRLFAS KGKELSELDA
SFLAKAKPGK AVKTKESEIH KEIAYMEAQI YHYSELLSEQ RAATRENIQR KQARTVNERE
ESDDEQMSDN NDSDDDSNDI PYNPKNLPLG WDGKPIPYWL YKLHGLNISY TCEICGNYTY
RGPKVFQRHF AEWRHAHGMR CLGVPNTAHF ANVTLIEDAI ALWQKLKASK DVERWRPETE
EEFEDSSGNV VTKKTFDDLR RQGLL
//
