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Database: UniProt
Entry: T1G0H5_HELRO
LinkDB: T1G0H5_HELRO
Original site: T1G0H5_HELRO 
ID   T1G0H5_HELRO            Unreviewed;      1722 AA.
AC   T1G0H5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=20214573 {ECO:0000313|EnsemblMetazoa:HelroP71177};
GN   ORFNames=HELRODRAFT_71177 {ECO:0000313|EMBL:ESN90733.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP71177, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP71177, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Simakov O., Marletaz F.,
RA   Cho S.-J., Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T.,
RA   Lv J., Arendt D., Savage R., Osoegawa K., de Jong P., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESN90733.1, ECO:0000313|EnsemblMetazoa:HelroP71177, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP71177}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AMQM01002373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB097753; ESN90733.1; -; Genomic_DNA.
DR   RefSeq; XP_009031222.1; XM_009032974.1.
DR   EnsemblMetazoa; HelroT71177; HelroP71177; HelroG71177.
DR   GeneID; 20214573; -.
DR   KEGG; hro:HELRODRAFT_71177; -.
DR   CTD; 20214573; -.
DR   OMA; WNIFDCI; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015101};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     46     65       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    174    200       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    518    542       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    554    572       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    592    613       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    644    667       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    687    703       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    715    741       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    997   1015       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1036   1055       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1067   1093       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1114   1140       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1252   1276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1338   1356       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1362   1385       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1397   1414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1452   1480       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1553   1577       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        6    207       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      524    745       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      760    991       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      995   1286       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1334   1585       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ESN90733.1}.
SQ   SEQUENCE   1722 AA;  195944 MW;  B2A4283EB1139025 CRC64;
     LAFPMGNLAA LRTFRVLRAL KTVAVVPGLK TIVGALMEAV RRLRDVIILT LFVLSIFALI
     GLQIYQGTLM NKCILTPDWM ALPEVNDTVR DVTINNSNWL ILPNGSPKLC GNGSGLGTCP
     PTHFCIPVGS NPNFDYTSFD NFGFALLCAF RLMTQDYWEN LYQMVLTTNG QFHIVFFILV
     IFMGSFYLVN LILAIVAMSY DDCQKQEQLE DEGEENDDED DDDKSDDDDD EDDDEVVVGD
     GGLKIYDGVV CSGDDENVDR DLENLMRVRF SSLRRQTPTT IQRNSNTSTH QQPTTQNNKT
     SLYHEQNYLT IPSPDPPRYK QQHPYHHPPQ QQEASRHHHG SWDGLPVIYH HQNANNFPQK
     SLANKVKAAH RASLRRQSLR MRRLSVDVAR TAATGFSDGD QLLATTDDGS KLALSKGKQD
     AENLTKEKIF EATHFLWFKK KFVPESKEEN EQQLQQLQPQ RMPAQQRHCQ TDDDDVDVDD
     DDDDGQMTSI AYQEKCNYLL YGWQCCPQWI KFASIVELFV MDAFVDLFIT LCIVVNTIFM
     ALDHEGMSEH LAQVLSVGNY VFTAIFTIEA FLKIVALGLQ RYLQDKWSCF DLIIVVLSLV
     ELGLSNIKGL SILRSFRLLR VFKLAKSWPT LNLLIGIIGR TMGALGNLCF VLAIIIFIFA
     VMGMQLFGEN YTVEKFGEMP RWNFSDFLHS FMIVFRVLCG EWIESMWACL FCSGIICIPF
     FLLTMIIGNL VVLNLFLALL LSSFGAESLQ GANQSDESGG EPNKLQEAVD RITRFGRFVK
     SHLLVYLSQS SSSISVSGLK EEEEEDDEEK TEIVYYINED DDDEIDENVN YSGNNNNNNN
     CNNNNNSNNN NNNNNNNNNN NNNNNNNNNV DDDDDSSSSS VSSQRREMIK LKSASNNNND
     NKDNTKQDDD DDDDDDDDDV DDDDDDDRDG GGLLNIEATE VKIEYIVYPD DCCPDSVTMQ
     FKKCFNKRLR SEISGSLVGR FFWKGRTLCY QLVEHKWFET FIIFMIICSS LTLAIEDKNI
     GEKPLLKKIL KYLDKSFSII FVFEMLIKLM AYGFKKYFTD AWCWLDFIIV AISLISLAAE
     GAGMGNIGAF RALRTLRALR PLRAVSRWEG MKVVVVNALI QAIPAICNVL LVCLVFWLIF
     SIMGVNLFGG CSFGRCLDET GEVANVSLIY NKNQCLALGG WDLSTASDVM TSDVPPHNYS
     WYNPKINFDH VPVAYLALFQ IATFKGWIDI MNYAIDSKEP GLQPEREVRV YMYLYFVFFI
     VFGSFFTLNL FIGVIIDNFN MQKRKSGSQQ LFMTEDQKKY YNAMKKLGSK QPQKPIPRPK
     LKCSMIIFQV ISNQKFDVAI MIAILLNMIT MAVEHYEQPE ELTFYLAVVN QIFIAIFTIE
     CLMKLIALRW YYFKQPWNVF DFIVVFMSIL GLAMKEIIEQ YFVSPTLLRV VRVFRVGRIL
     RLVKSAKGIR TLLFSLAVSL PALVNIGLLL FLIMFIYAIF GMSFFMHVKY NNGIEELFNF
     ETFFRSMTLL FQISTSAGWD GVLAGGGGVV DEASHTSDPD DRPNGDCGNS GMAVLYLVSY
     LVVSYLVVIN MYIAVILENF SQATDDIRQG LTQDDFDMYY EVWERFDEKA TQFIPLEIMN
     RFVDALEHPL RIPTPNRCKL VSLNIPICEG DKVHCLDILD ALTKNFLGTS GDMGGELDRL
     KNSIGYKPIT TTLRRRRETY CSVVIQRAWR KYKNSNKGNV NK
//
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