ID T1G4F3_HELRO Unreviewed; 354 AA.
AC T1G4F3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN Name=20215951 {ECO:0000313|EnsemblMetazoa:HelroP81526};
GN ORFNames=HELRODRAFT_81526 {ECO:0000313|EMBL:ESO01582.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP81526, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01582.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP81526}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR EMBL; AMQM01004951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01004952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096743; ESO01582.1; -; Genomic_DNA.
DR RefSeq; XP_009020236.1; XM_009021988.1.
DR AlphaFoldDB; T1G4F3; -.
DR STRING; 6412.T1G4F3; -.
DR EnsemblMetazoa; HelroT81526; HelroP81526; HelroG81526.
DR GeneID; 20215951; -.
DR KEGG; hro:HELRODRAFT_81526; -.
DR CTD; 20215951; -.
DR eggNOG; KOG1192; Eukaryota.
DR HOGENOM; CLU_784308_0_0_1; -.
DR InParanoid; T1G4F3; -.
DR OMA; WIEYVTH; -.
DR OrthoDB; 382054at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 2.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF162; UDP-GLYCOSYLTRANSFERASE FAMILY 305 MEMBER A1, ISOFORM A-RELATED; 1.
DR Pfam; PF00201; UDPGT; 2.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 2.
DR PROSITE; PS00375; UDPGT; 2.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|RuleBase:RU362059};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW Transmembrane {ECO:0000256|RuleBase:RU362059};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362059}.
FT TRANSMEM 135..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362059"
SQ SEQUENCE 354 AA; 40381 MW; E3DC9AB5865D403F CRC64;
NTLILDWLPQ NDVLGHPSTK LFITHCGNNG IHEALYHGVP MLGFPLFAEQ GENCRRMIAF
EFGIKMDIFT FTEAELVENV LEILTNPKYK SSIKQMSKVF KDQPMAPLQK ALFWMEHVIK
HGGSHLRSSA IDLPLYQFLC FDTIAVLLLI ITIVTFAVFQ VSKFSLLYFY EVDHHFNSFI
PNFPNHISVA GLTCSPAQNL PKNILDFING RIVDGKDPGV ILMSFGSFVD YMPNRLIEKF
FKVFESLNET ILVRYKIKQN DTQPKPTIPT NVMISDWLPQ NDLLGHPSTK LFITHCGNNG
QHEALYHGVP MLGFPLFAEQ DENARKVIAL QFGLIMDIMT FTEKELFGWF ISVF
//
