ID T1G7R2_HELRO Unreviewed; 497 AA.
AC T1G7R2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=phenylalanine--tRNA ligase {ECO:0000256|ARBA:ARBA00012814};
DE EC=6.1.1.20 {ECO:0000256|ARBA:ARBA00012814};
GN Name=20217109 {ECO:0000313|EnsemblMetazoa:HelroP90419};
GN ORFNames=HELRODRAFT_90419 {ECO:0000313|EMBL:ESN91107.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP90419, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN91107.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP90419}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Phe-tRNA synthetase alpha subunit type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00006703}.
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DR EMBL; AMQM01008097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097722; ESN91107.1; -; Genomic_DNA.
DR RefSeq; XP_009030783.1; XM_009032535.1.
DR AlphaFoldDB; T1G7R2; -.
DR STRING; 6412.T1G7R2; -.
DR EnsemblMetazoa; HelroT90419; HelroP90419; HelroG90419.
DR GeneID; 20217109; -.
DR KEGG; hro:HELRODRAFT_90419; -.
DR CTD; 20217109; -.
DR eggNOG; KOG2784; Eukaryota.
DR HOGENOM; CLU_025086_2_2_1; -.
DR InParanoid; T1G7R2; -.
DR OMA; QIEGWVM; -.
DR OrthoDB; 4619at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009328; C:phenylalanine-tRNA ligase complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IBA:GO_Central.
DR CDD; cd00496; PheRS_alpha_core; 1.
DR Gene3D; 1.10.10.2320; -; 1.
DR Gene3D; 1.10.10.2330; -; 1.
DR Gene3D; 3.30.1370.240; -; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004529; Phe-tRNA-synth_IIc_asu.
DR InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR InterPro; IPR040724; PheRS_DBD1.
DR InterPro; IPR040586; PheRS_DBD2.
DR InterPro; IPR040725; PheRS_DBD3.
DR NCBIfam; TIGR00468; pheS; 1.
DR PANTHER; PTHR11538:SF40; PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR11538; PHENYLALANYL-TRNA SYNTHETASE; 1.
DR Pfam; PF18552; PheRS_DBD1; 1.
DR Pfam; PF18554; PheRS_DBD2; 1.
DR Pfam; PF18553; PheRS_DBD3; 1.
DR Pfam; PF01409; tRNA-synt_2d; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 229..480
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 497 AA; 56680 MW; 0BB00138B94739F5 CRC64;
MSDFVELVLT TLTSQGKFDS LNLSEKLSID HQKIVGAVKS LQSLGDVIST EQTSQTRWQL
TPEGQEVMER GSHEAVVFRN VPEGGIRQDD LMNLVGSSYG KIGFSKAMSS NWISIDKKAD
GGPRVLRKVE TIEDHVQKQC RLVRGGQIDQ LTDQQKNELK KRKLISEIKL TSYVVSMGSN
FTTNIEKQET DLTQEMITSG AWKTKQFKAY NFSAKGLDLH GGHLHPLLKV RTQFRQIFLE
MGFTEMPTNN FVESSFWNFD ALFQPQQHPA RDAHDTFFVS DPEHARDFPM EYMERVKKVH
SVGGYGSLGY RYNWSELEAS KNIMRTHTTA VSARMLYQLA IQPTFTPSKF FSIDRVFRNE
TLDATHLAEF HQIEGLVADY GLTLGDLMGY IQEFFKKYGI QKLKFKPAYN PYTEPSMEVF
SYHEGLKKWV EIGNSGVFRP ELLLPMNLPP HVSVIAWGLS LERPTMIKYG IQNIRDLFGP
KVDLQKIYDS PICRLGS
//
