ID T1G9J3_HELRO Unreviewed; 621 AA.
AC T1G9J3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Aminopeptidase P N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20217739 {ECO:0000313|EnsemblMetazoa:HelroP97843};
GN ORFNames=HELRODRAFT_97843 {ECO:0000313|EMBL:ESO08958.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP97843, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO08958.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP97843}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR EMBL; AMQM01003129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096023; ESO08958.1; -; Genomic_DNA.
DR RefSeq; XP_009012980.1; XM_009014732.1.
DR AlphaFoldDB; T1G9J3; -.
DR STRING; 6412.T1G9J3; -.
DR EnsemblMetazoa; HelroT97843; HelroP97843; HelroG97843.
DR GeneID; 20217739; -.
DR KEGG; hro:HELRODRAFT_97843; -.
DR CTD; 20217739; -.
DR eggNOG; KOG2413; Eukaryota.
DR HOGENOM; CLU_011781_2_2_1; -.
DR InParanoid; T1G9J3; -.
DR OMA; EPGMILS; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 12..148
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 330..545
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 558..621
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 621 AA; 70236 MW; 468DDB65DBB152BA CRC64;
MAVAKKSTTV LLQRLRSLMK NASIVNPVIN GYIVPSGDAH LSEYIAPCDR RREFISGFTG
SFGIAVVTDS KAALWTDSRY YLQAEEELDE NWTLMKMGLP DTPTLGKWLR DELPNDGRVG
VDPFLMSQNN WQELSDELEL FGKSLVSVAK NLIDTIWDDR PPTPTDLIFV HPIQYAGEPW
HKKIDNLRSE MAKKNSSVHV VSALDEVAWL FNLRGSDVQF NPVFFSYAII TMDQAFFFVD
ERKLTDDVRQ HLMTSAGDSH VASVVIEPYE KVLERLKKIV DESTGANDKI WISLNINHAI
FGVVPKMKQL KLYSAVEVAK SVKNEVEVQG MKNCHIRDAV ALCEFFTWLE KEIEHRNVTE
IEAADYAEAC RKKQALFVSL SFDTISSSGE HGAIVHYKPT PETNKDITKK EIYLIDSGAQ
YRDGTTDVTR TVHFGTPNDY EKECFTSVLK GHIALDNATF PNRTKGSSLD SMARQYLWSL
GLNYGHGTGH GVGSFLNVHE GPCGIRVDTR ADEIALKKGM VLSDEPGYYE DGKFGVRIEN
LFVVVDKQTK YNYLKTGYLG FEHVTLVPIQ RKMINKDMLT ADEVKWLNDY HKKCRDIVGS
EAKRQGKNDV YDWIVKETEA L
//
