ID   T1GBH9_MEGSC            Unreviewed;       453 AA.
AC   T1GBH9;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:MESCA000611-PA};
OS   Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC   Phoridae; Megaseliini; Megaselia.
OX   NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA000611-PA, ECO:0000313|Proteomes:UP000015102};
RN   [1] {ECO:0000313|Proteomes:UP000015102}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Durham, NC isolate 2 -- Noor lab
RC   {ECO:0000313|Proteomes:UP000015102};
RA   Hughes D.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:MESCA000611-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; CAQQ02103929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1GBH9; -.
DR   STRING; 36166.T1GBH9; -.
DR   EnsemblMetazoa; MESCA000611-RA; MESCA000611-PA; MESCA000611.
DR   HOGENOM; CLU_009902_4_2_1; -.
DR   OMA; IDVVCDM; -.
DR   Proteomes; UP000015102; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProt.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR11851:SF149; GH01077P; 1.
DR   PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000015102}.
FT   DOMAIN          53..199
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          235..368
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   453 AA;  50382 MW;  50B164BD49AA974B CRC64;
     MALKVLFCAN NLKQLTRGAQ IIARSKSSYA PDLKKALLNI PATQITTIDN GLRVASEDSG
     AATATVGLWI DAGSRYETEA NNGVAHFLEH MAFKGTAKRS QTDLELEVEN LGAHLNAYTS
     REQTVFYAKC LSKDVPKAVE ILADIIQNSK LGESEIERER GVILREMQEV ESNLQEVVFD
     HLHATAYQGT PLGQTILGPT KNIKSIGKSD LQDYISNHYK ASRIVFLQNT YDGKPPAVSP
     CRFTGSEIRV RDDSLPLAHV AIAVEGCGWT DQDNIPLMVA NTLIGAWDRS QGGGVNNAST
     LARHSAESNL CHSFQSFNTC YKDTGLWGIY FVCDPLQCED MLFNVQQEWM RLCTMITEGE
     VERAKNLLKT NMLLQLDGTT PICEDIGRQI LCYNRRIPLH ELEARINAVS VQNIRDVCMK
     YIYDRCPAVA AVGPVEALPE YGRIRSSMYW LRV
//