ID   T1H5P1_MEGSC            Unreviewed;       889 AA.
AC   T1H5P1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
OS   Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC   Phoridae; Megaseliini; Megaselia.
OX   NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA012024-PA, ECO:0000313|Proteomes:UP000015102};
RN   [1] {ECO:0000313|Proteomes:UP000015102}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Durham, NC isolate 2 -- Noor lab
RC   {ECO:0000313|Proteomes:UP000015102};
RA   Hughes D.;
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:MESCA012024-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   STRING; 36166.T1H5P1; -.
DR   EnsemblMetazoa; MESCA012024-RA; MESCA012024-PA; MESCA012024.
DR   HOGENOM; CLU_324822_0_0_1; -.
DR   Proteomes; UP000015102; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01670; Death; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR021861; THO_THOC1.
DR   PANTHER; PTHR13265:SF0; HPR1; 1.
DR   PANTHER; PTHR13265; THO COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF11957; efThoc1; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000015102}.
FT   DOMAIN          806..888
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
SQ   SEQUENCE   889 AA;  99382 MW;  0635AF5135746FDE CRC64;
     NHTVYAREHF IRVVDPEKPK GRTLFLLNIP PYVSEQNLQK VFSKCGKVEN ILFAEKPGRE
     ESQKWNSRFV HIRTPYKYKV AYVIFKEGII MRCWELIAVA GPFGGGICNI VSKSPKSLLK
     ATRFDFYXIP AKTVHLISPA KGVTTGIAMA PVGKAKGCCE AKHKLGLSVI HSVKTSKSIS
     GGGTKLPQES RSCRSATAVM KFAANLGATK GNIFNCSEVF LEITKSFTKH FAISDEADEV
     HPNCCIHVPA EAKQDATDPL IDVLISLAKM LDLPGFKXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XDSNFRRTVL LQFLILFQYL QSTVKFKTXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXDSLTK LWNLCPDNLN ACKSEDRNFL PSLDSYFEAP KEKNDPAYEW RALRLLARQS
     PHFFNLTNGT SYKISEYIEC KEKVTEEKAE TKIDTNTNSA NSIKEEAVEA IEEAPEVGTH
     ANRKDHEGEE VLVKDDVNTH KTSTATKENI EDISKKIGAD WKKLAKKLGY KPDEIEFFET
     ENESIPSQCQ AMLSNWFDDD DDASLDNLAY ILEGLELVSA SEFIKAIIE
//