ID T1HCX2_RHOPR Unreviewed; 1210 AA.
AC T1HCX2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:RPRC001887-PA};
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC001887-PA, ECO:0000313|Proteomes:UP000015103};
RN [1] {ECO:0000313|Proteomes:UP000015103}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:RPRC001887-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; ACPB03000352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1HCX2; -.
DR STRING; 13249.T1HCX2; -.
DR EnsemblMetazoa; RPRC001887-RA; RPRC001887-PA; RPRC001887.
DR VEuPathDB; VectorBase:RPRC001887; -.
DR eggNOG; ENOG502RB63; Eukaryota.
DR HOGENOM; CLU_003534_0_0_1; -.
DR InParanoid; T1HCX2; -.
DR OrthoDB; 3740683at2759; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45813:SF8; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 660..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 804..826
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 855..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 102..187
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 206..300
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 283..367
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT REGION 1184..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 137104 MW; FF075808B44820E7 CRC64;
RWRYEVRVRV ANVSALSIQH PGQTLFNFLE RQIGRYFRPF SLRKFEDLRI LNITESGNVT
FHFFGSVMDA SKVRDASNKL LERGKLGEIS LLPSEYIFYQ EPGLNLNEVT GDEVIREGHQ
LVLSCIAQGS SHMSFRWLKD GDPINVSKSA GIMWTKLIPK TDRQQYTAVL GIEKVDALDE
GHYTCQIFDW GLQECKSIYV EVVQAPQVQV LPMSASLQKG ESINLKCVSP NEGRWSDQDQ
IGYSWARDKK LFPLNPGQEV WEDLKPSGSI LRVQNIQKST TYTCKAHTSA ATREQSVRID
VINHTSVAMC KEEIQYGIKW SIASPGSTAL SECPFKYLGV ARRQCLIDQP GIAFWQNPDF
SNCISERFDK IIRDFRILAR GFVKTSIERT LSELVLFLEE QGELYPGEGE PIVEFLQDIL
NYINRTSSWN DLIDSTIYFY KSINLILIYN ESIINENKLK DLQILVNRWS LLFGEHMNGT
MSHFSFDAFV IDIMKVIDVN HNSYYIPTLS NSYPLWYNVR IAVHVSTDDQ EDSLYTTNRI
AIINYRNISK FLPVASTQKT SDGSEITYEI QSNIISVAIA GQLTIRLDIE LQLRKVKEGW
NMTCANAPSL GTSWDISSCH YSAKKYNITH CVCRFPGVYT ALITKHSSLN AEGIYKNLRL
ASIVVIGCTC CLIQSLLALI LLLIRWWYRK TCVLFLKLQC CTSVTAIMSI FIYTSRFAVP
QSSFTYTTVL MEALMLLGIS SHLSKLLVVY TEVVRLPNVK NIKKTVFGIT TGVTLLAVLC
SLLAHKISGN TLKSWWLPYD SAIFFIAVTC GILIIVMFIF LFCNLLRRLK FLLCVQDAKT
NHIITRRIGL LKRTAVLFTS VVSVAVSSIL YVNSYSKFYH YLFSALCALL GFIIFLCYVL
HSESSLNLHL LTQLKLQKAK EQEFSSESDN NLFNFFTKQE AEVESDCAPP CIKSTPTKLI
SELTPMNEKL ITKPKMVTFN GEDVICEKKE VEDVDLEIYP NSPKKYKCIN LAIMPSSIDA
SNEESEALNP QVKETAFKLE NIHPVCDVPD VLTTRACVEL DLKMPNLIIT SEGTSLPNTG
IISPVVTPSK DTSVLPQHCS EVSSDVQMIV AEEEEEEEED DDENSCYIDM KQSEDPLLNP
LQVGEALPTI LEVEDSEDKD VLDRITHDLD YLLNRRPDNE VLSYQRHKKQ TTSDTTKPIP
SSTFVAKTTL
//
