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Database: UniProt
Entry: T1HEU1_RHOPR
LinkDB: T1HEU1_RHOPR
Original site: T1HEU1_RHOPR 
ID   T1HEU1_RHOPR            Unreviewed;       317 AA.
AC   T1HEU1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-JUL-2017, entry version 31.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Hemiptera; Heteroptera;
OC   Panheteroptera; Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC002563-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|EnsemblMetazoa:RPRC002563-PA}
RP   NUCLEOTIDE SEQUENCE.
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC002563-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; ACPB02028836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; T1HEU1; -.
DR   EnsemblMetazoa; RPRC002563-RA; RPRC002563-PA; RPRC002563.
DR   VectorBase; RPRC002563-RA; RPRC002563-PA; RPRC002563.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028820; Na_channel_60E.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF257; PTHR10037:SF257; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015103};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     56     80       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       16     90       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   317 AA;  34125 MW;  47BFB055932B5BEB CRC64;
     MSAGVLQTTS QLATCRGLMT SAGWNDVLES LMVQPPECDP TYNGQLNGNC GHPLLAITYF
     TSFIIISYMI VINMYIAIIL ENFNQAHQEE EIGIVEDDLE MFYIRWSKRK REGSLVECDD
     GGTQSSSPGG WQGRLSALLH VHRGSRTSSR KSSRTSDASD MSELGTAWLN LPLLLLSGTQ
     PNGTDHDSAK WEGSGSDGDG PVVGMWKQSS LDLPSSGTPG VSITVTEPSP DSNRCDAGTL
     SGDLVAAGQS NVSSANQPLL ASRQTNSATP ASPVASTLCR RDSDAQIKRA AFRRTSDLPR
     LVQALVHRES EEYEPDS
//
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