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Database: UniProt
Entry: T1ICG6_RHOPR
LinkDB: T1ICG6_RHOPR
Original site: T1ICG6_RHOPR 
ID   T1ICG6_RHOPR            Unreviewed;      5107 AA.
AC   T1ICG6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-JUL-2017, entry version 29.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:RPRC013986-PA};
DE   Flags: Fragment;
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Hemiptera; Heteroptera;
OC   Panheteroptera; Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC013986-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|EnsemblMetazoa:RPRC013986-PA}
RP   NUCLEOTIDE SEQUENCE.
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC013986-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
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DR   EMBL; ACPB02047334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACPB02047335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACPB02047336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; RPRC013986-RA; RPRC013986-PA; RPRC013986.
DR   VectorBase; RPRC013986-RA; RPRC013986-PA; RPRC013986.
DR   OMA; EHMPNDT; -.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 4.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015103};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4450   4469       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4632   4650       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4718   4737       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4844   4868       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4906   4926       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4980   5003       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       76    129       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      136    181       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      191    245       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      251    309       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      317    377       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      560    785       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1241       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1464   1684       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   5107 AA;  577389 MW;  C4A79657FB7929AD CRC64;
     EDMVCLSCTA TGERVCLAAE GFGNRHCFLE NIADKNIPPD LSTCVFVIEQ ALSVRALQEL
     VTAAGTEEGK GTGSGHRTLL YGNAILLRHN SDMYLACLST SSSNDKLSFD VGLQEHSQGE
     ACWWTVHPAS KQRSEGEKVR VGDDLILVSV ATERYLHTTK ENDQSVVNAS FHVTHWSVQP
     YGTGISKMKY VGYVFGGDVL RFFHGGDECL TIPSTWSAEA GQNFVIYEGG SVMSQARSLW
     RLELARTKWA GGFINWYHPM RIRHLTTGRY LGVNEANELH LVTRDEATTA LSTFILRQEK
     DDQKVVMEDK DLEVIGAPII KYGDSTVLVQ HSESGLWVTS KSYETKKKGV GKVEEKQAVL
     HEEGKMDDGL DFSRSQEEES RTARVIRKCS SLFTQFIRGL EELQMNRRHS LFCATVNLNE
     MVMCLEDLIN YFAQPEEDME HEEKQNKLRA LRNRQDLFQE EGILNLILEA IDKINVITSQ
     GFLVSLAGDE SGQSWDVISG YLYQLLAAII KGNHTNCAQF ANTNRLNWLF SRLGSQASGE
     GTGMLDVLHC VLIDSPEALN MMREVLTTKV PFIISLLEKH GRDPKVLDVL CSLCVGNGVA
     VRSSQNNICD FLLPGKNLLL QTQLVDHVAS VRPNIFVGRV EGSAVYQKWY FEVTLDHMEQ
     TTHMTPHLRI GWANTAGYVP YPGGGEKWGG NGVGDDLYSY GFDGAALWTG GRKTIVLPHA
     TEPYIRKGDV IGCAFDLTVP VITFTFNGTH IRGAFRDFNL DGMFFPAISC SSKLSCRFLF
     GGDHGRLKYV PPEEFSPLVE SLLPQQVLSI DPCFYFGNLN KCVISGPFPV EDDAAFVPIP
     VDTTMITLPN HVESIRDRLA ENIHEMWAMN KIEAGWMYGE VRDDVRRIHP CLVQFDKLPP
     AEKRYDTQLA VQTLKTIIAL GYHITVDKPP SRIKSVRLPN EPFMQANGYK PAPLDLGAIT
     LTPKMEELID QLAENTHNLW AKERIQQGWT YGLNEDPDLS RSPHLVPYCK VDELIKKANR
     DTASETVRTL LVYGYNLDPP TGEQTEALLA EASRSKHQAF RTYRAEKNYA VTSGKWYFEF
     EILTAGPMRV GWAIADYSPG TQLGSDDCSW AFDGFNAVKI HGNHHIFFGK YYEIGDVVGS
     FLDLCDNTIS DFLNILFVVN EEKVYSGVSE SFGRQWQIGD VVGVFLDLLD HTISFSLNGE
     LLMDALGGET SFADVQGDGF VPAFTLGVGQ KAKLTFGQDV NSLKFFTTCG LQEGYEPFCV
     NMNRAVTYWY TKDQPIFENT EDYADTKIDV TRIPPGSDTP PCLKISHNTF ETMEKANWEF
     LRLSLPVICE STFIDEAEKI RRWQEIRIRQ HRLLAESDQT TPAHIEQIMK SGFSMSDIKG
     LHRGYSEDAV EADEMRQVPP RPPRKGSLSR PEDEKFDSTA SMGNMNRSTS ELDFNRYNGE
     AADGTDKKKR GRSPFRFFSR KRDASGERAK KSRTPEPAAL LLEPPRTPVL QRGGSMIRSS
     GPEMKPPSPL AERGGPKAMS VIQASGIETV GNMFDAECLK LINEYYYGVR IYPGQDPTHV
     YIGWVTTQFH LHSKDFNQNR VRKSTVTLAD EFHRVIESFE RQSCYMVRAD ELYNEVTQDP
     SGKGASQGMT VGCFIDTATG FMTFTCEGKE TNYKYKPDTK LFPAIFVEAT SKEVLQIELG
     RTPTTLPLSA AVLRNSEKHV VPQFPPRLKV QCLKPHQWAR VPNVSLQVHA LKLSDIRGWS
     MLCEDPVSML ALHIPEEDRC MDILELIEME KMLSFHAHTL TLYSALCYQS NYRAAHALCR
     HVDQKQLQYA IRSEYMSGPL RRGFYDLLIS LHIESHATTV EVCKNEFIIP LGSELKELYE
     DPEMGHSLRS LQTVSVLPQM KMTDITVMAS VFRETIESIN TLYSPYFPLD AVRDYVMTAL
     EEAVEINQVH NRDPVGGSNE NLFLPLLKLV DRLLLVGMLR DEDVMKLLIM FNPETWDLTF
     EKDGKDEHRK GLLQMKMAEG AKLQMCYLLH HLCDIQLRHR VESIINFSYD YIADLQSDQL
     RRYIEIKQSD LPSSVAAKKT REFRCPPREQ MNAILSFKNF DEEDKENSPC GDDLRERLNA
     FHEQLLQKVS LLALQEPSDE ENAEEQNEKP GIFKKLYNFI NAVKELEEPP KEEEEPVKKT
     PEEIFRKILI STIVRWAEES QIETPKLVRE MFSLLVRQYD SIGELMNALA KTYVINAKTK
     DDVANMWVGL SQIRALLPVQ MSQEEEGLMR MRLWLLVNNH TFFQHPDLIR VLRVHENVMA
     VMINTLGRRS QAQSDAPQAG QEGEPVSKEK VSNLSELMLM FLCYFCRTSR QNQKAMFDHL
     NFLLENSNIL LSRPSLRGST PLDVAYSSLM ENTELALALR EHYLEKIAIY LSRCGLQSNS
     ELVEKGYPDL GWDPVEGERY LDFLRFCVWV NGESVEENAN LVIRLLIRRP ECLGPALRGE
     GEGLLRAIID ANKMSERIAD RRKLMDEAEG TMTIMQFEHP LPESEDDEDY IDTGAAILAF
     YCTLVDLLGR CAPDSNVIAQ GKNESLRARA ILRSLVPLED LFGVLSLKFT LTNPAAGEER
     PKSDVPSGLI PSHKQSVVLF LERVYGIEQQ DLFFRLLEEA FLPDLRAATM LDRARTDGSE
     SEMALAMNRY IGNSILPLLI KHSKFYGDAD NYASLLDATL HTVYRLSKNR MLTKGQREAV
     SDFLVALTSQ LQPSMLLKLL RKLTVDVSQL SEYTTVALRL LTLHYDRCAK YYGSSGGQGG
     GSSDEERKLT MILFSNIFDS LSKMDYDPEL FGKALPCLTA IGCALPPDYS LSKNYDDEWY
     GAKAAGPSDG PYNPQPINTS SVALNNDLNS IVQKFSEHYH DAWASRKMEN GWVHGEQWSD
     SSKSHPRLKP YAMLNDYEKE RYKEPVRESL KALLAIGWSI EHSEVDIPSN NRGNSIRRQS
     KVTNNYFFNN ASPFNYHPNP IDMSNLTLSR ELQNMAERLA ENAHDIWAKK KKEELVTCGG
     GIHPQLVPYD LLTDKEKRKD RERSQEFLKY LQFQGFKLHK PNRGAADQDQ QAAAAVTGES
     RFAYSLLEKL IQYTDKATIN MKILKPSSTF SRRSSFKTCT RDIKFFSKVV LLLVEKYFST
     HRNYFIAVAT ASNNVGAASL KEKEMVASLF CKLANLLRSR LGAFGADVRV TVRCLQVLVK
     AIDAKSLVKN CPEFIRTSML TFFNNTADDL GQTIQCLTEG RYSHLRGTHL KTSTSLFYIN
     DVILPILTAM FDHLAACDYG SDLLLDEIQV ASYKMLGSLY TLGIDPTLTH ERKYLKTEIE
     RHRPAIGSCL GAFSSTFPVA FLEPHLNKHN QYSLVNRIAD HSLEAQDVLA RMESTMPTLD
     TILTEVDQFI ESEKSHSTAP HVIDVILPML CAYLPVWWNQ GPDNISLTAG NYVTMVTSDH
     MNQLLKNVLK LIKNNIGNEN APWMTRIAAY TQQIIINSSE ELLKDPFLPL TLTVKKRVDN
     MYHKEESLRG FLKSTTEDTS QVEAEIQEEW QLIVRDIYAF YPLLIKYVDL QRNHWLRNNI
     PEADDLYNNV ADIFNIWSKS QYFLKEEQNF ISANEIDNMT LIMPTASRRS AIVADSGAAP
     VGSSGKKKKK HRDKKRDKNK ELQASLMVAC LKRLLPVGLN LFAGREQELV QHCKDRYLKK
     LPEYDIADFA KTQLTLPDKI DPGDEMSWQH YLYSKLGTKK EASSDKPQQI DEVVDRIVAM
     AKVLFGLHMI DHPQLQSKTQ YRSVVSTQRK RAVIACFRQL SLHALPRHRV INIFARTYCE
     LWLQEENVGQ EVMIEDLTQS FEDSELKKVD SEEEEGKPDP LTQLVTTFCR GAMTERSGAL
     QEDPLYMSYA EITAKSCGEE EEEGGDEEGE AGEEEGGASI HEQEMEKQKL LFHQARLANR
     GVAEMVLLHI SACKGVPSEM VMKTLQLGIS VLRGGNVNIQ MGMLNHLKEK KDVGFFTSIA
     GLMNSCSVLD LDAFERNTKA EGLGVGSEGA AGEKNMHDAE FTSTLFRFIQ LTCEGHNLEW
     QNYLRTQAGN TTTVNVVICT VDYLLRLQES IMDFYWHYSS KELIDPAGKA NFFKAIGVAS
     QVFNTLSEVI QGPCTQNQQA LAHSRLWDAV GGFLFLFSHM QDKLSKHSSQ VDLLKELLNL
     QKDMITMMLS MLEGNVVNGT IGKQMVDTLV ESASNVELIL KYFDMFLKLA DLTSSPSFLE
     LDPNHEGWVT PKDFKEKMEQ QKSYTPEEID FMLLCCETSH DGKIDYVGFT ERFHEPAKEI
     GFNLAVLLTN LSEHMPNEPR LARFLETAGS VLNYFEPFLG RIEIMGSSKR IERVYFEIKE
     SNIEQWEKPQ IKESKRAFFY SIVTEGGDKE KLEAFVNFCE DAIFEMTHAS GLMAVDDGSG
     GSGGKQRKTS FSYIGDEDEE RKSPIKRGWQ AVKDGISCTI SMMSPSNIKA KINEMQQMTV
     LELLVSFFKL FFYGFYYTGY GFSLVLKYIG GIIFSLMSGP PVEDTVVEVK EEEKPGALRM
     IAALPPAEES PPSSADFTKE ESQPPRGQEG SPLAIEEGGE RTGEEGGEQP AATEEQPSVT
     LADILGGEAA RKEAAQTAEV AAQQEAVMAA FEAEKKEEKV STEPSAVSQI DFNKYTHRAV
     SFLARNFYNL KYVALVLAFS INFILLFYKV TTLGEVEENG GSGEINAASS VNLSGEINGS
     DGAGSGEGGG SGENDEEDPL EFVHVNEDFF YMAHVMRLAA LLHSLVSLAM LIAYYHLKVP
     LAIFKREKEI ARRLEFDGLY IAEQPEDDDI KSHWDKLVIS AKSFPVNYWD KFVKKKVRQK
     YSETYDFDSI SSLLGMEKTS FSAQQEEGSG LIYFIMNIDW RYQLWKAGVT ITDNAFLYSF
     FYFIFSILGN FNNFFFAAHL LDVAVGFKTL RTILQSVTHN GKQLVLTVML LTIIVYIYTV
     IAFNFFRKFY VQEEDEEVDK KCHDMMTCFV FHLYKGVRAG GGIGDEIEPP DGDDYEVYRI
     MFDITFFFFV IVILLAIIQG LIIDAFGELR DQLESVKEDM ESNCFICGIG KDYFDKVPHG
     FDTHVQQEHN LANYMFFLMH LINKPDTEYT GQETYVWNMY QKRCWDFFPV GDCFRKQYED
     ELGGGGG
//
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