ID   T1ID30_RHOPR            Unreviewed;       306 AA.
AC   T1ID30;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=Mitochondrial 2-oxoglutarate/malate carrier protein {ECO:0000256|ARBA:ARBA00040264};
DE   Flags: Fragment;
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC014200-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|Proteomes:UP000015103}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC014200-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-
CC         oxoglutarate(in); Xref=Rhea:RHEA:71587, ChEBI:CHEBI:15589,
CC         ChEBI:CHEBI:16810; Evidence={ECO:0000256|ARBA:ARBA00036491};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate(out) + maleate(in) = 2-oxoglutarate(in) +
CC         maleate(out); Xref=Rhea:RHEA:71599, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:30780; Evidence={ECO:0000256|ARBA:ARBA00036076};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate(out) + malonate(in) = 2-oxoglutarate(in) +
CC         malonate(out); Xref=Rhea:RHEA:71591, ChEBI:CHEBI:15792,
CC         ChEBI:CHEBI:16810; Evidence={ECO:0000256|ARBA:ARBA00036366};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate(out) + oxaloacetate(in) = 2-oxoglutarate(in) +
CC         oxaloacetate(out); Xref=Rhea:RHEA:71603, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:16810; Evidence={ECO:0000256|ARBA:ARBA00036462};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate(out) + succinate(in) = 2-oxoglutarate(in) +
CC         succinate(out); Xref=Rhea:RHEA:71595, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:30031; Evidence={ECO:0000256|ARBA:ARBA00036084};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR   EMBL; ACPB03022134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1ID30; -.
DR   STRING; 13249.T1ID30; -.
DR   EnsemblMetazoa; RPRC014200-RA; RPRC014200-PA; RPRC014200.
DR   VEuPathDB; VectorBase:RPRC014200; -.
DR   eggNOG; KOG0759; Eukaryota.
DR   HOGENOM; CLU_015166_14_1_1; -.
DR   InParanoid; T1ID30; -.
DR   OMA; TLWRGAI; -.
DR   OrthoDB; 2086232at2759; -.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   PANTHER; PTHR45618:SF9; MITOCHONDRIAL 2-OXOGLUTARATE_MALATE CARRIER PROTEIN; 1.
DR   PANTHER; PTHR45618; MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT   REPEAT          15..100
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          109..200
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT   REPEAT          209..298
FT                   /note="Solcar"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ   SEQUENCE   306 AA;  33561 MW;  E33EB7235C80D0BD CRC64;
     IMASKEEKKE IPNYLKFVFG GLAGMGATCF VQPLDLLKNR MQLSGIGGGA KEYKTSFHAF
     KAVLQKEGFF AFYNGLSAGL LRQATYTTSR LGVYTVLFSK FSSDDGAPPS FLIKALCGMA
     AGVVGAFVGT PAEVALVRMT SDGRLPVDQR RNYSSVFNAL FRIVKEESVV TLWRGAIPTM
     GRAMVVNAAQ LASYSQAKEI LTNSGYYQEG IFLHFSASMI SGFVTTVASM PVDIAKTRIQ
     NMKVIDGKPE FTGSLDVIMK ILRKEGIFAL WKGFTPYYAR LGPHTVLTFI FLEQLNHAYK
     TNALKL
//