ID T1IKH0_STRMM Unreviewed; 1770 AA.
AC T1IKH0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR001419-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR001419-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; JH430530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 126957.T1IKH0; -.
DR EnsemblMetazoa; SMAR001419-RA; SMAR001419-PA; SMAR001419.
DR eggNOG; KOG3619; Eukaryota.
DR eggNOG; KOG4209; Eukaryota.
DR HOGENOM; CLU_238847_0_0_1; -.
DR OrthoDB; 3087296at2759; -.
DR PhylomeDB; T1IKH0; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd15039; 7tmB3_Methuselah-like; 1.
DR CDD; cd07302; CHD; 2.
DR CDD; cd12306; RRM_II_PABPs; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR032628; AC_N.
DR InterPro; IPR009398; Adcy_conserved_dom.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF1; ADENYLATE CYCLASE TYPE 8; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16214; AC_N; 1.
DR Pfam; PF06327; Adcy_cons_dom; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00044; CYCc; 2.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1770
FT /note="adenylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004579272"
FT TRANSMEM 187..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 806..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 834..853
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 859..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1265..1286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1292..1314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1335..1353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1396..1414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1421..1439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1459..1477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..402
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DOMAIN 507..584
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 961..1088
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 1540..1676
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1770 AA; 202902 MW; A80A2E5F9DE2DE8A CRC64;
MSCSSFTMSF PLSIILTTLN LLFHRVICQQ QQQQPCSNGA VYPSLNRCLF ECRNDEYNNN
ASHPDEKHEY KVLVLSVNDF SITTNGFLVA DLPIPELPTN LYVIHNFTAR ICYPLDQNFI
SCDKWSLESD EFVLSNDSHH LWTIPDNKIY TLGQFYMFMI DNESLPVVCI SQKAIEHHKN
IVAVDKWFLG LHIVSATSLI IAFVCCVRFP ALNVRHNYNL LCHMCVMSVA YWTLVIEYFM
RQWKTTPDAC LVVAFIKQFA FLATFFWINV QAIDLFLRFN NLSINSTPGS NTRRFVYYSG
YAWGCPFAVS CITLIVAKSD VELRYRPNWQ QFCWFDYKYK LTGLIYFYAP IAIILVVNSG
LFGLTMWKLY TVGKMVSNVN KRIHQQLLQL CVKLLVITGL CWSMEVIGWA VGEYKNNMFN
AKKIEHIEEF DNDDDEFGFG RILREMDEEE KQNHEQNLKI EQFHNLNSDK ILNEVEIEIQ
VQPSPHVDNN TIFISCKEEE KQEIHSRSIH VGNIAFTATP EDLKQHFNAC GSIKRVTIVY
DKVTGRSRGF AYIEFTDEDA VNNAVALNNS LFRDRNIKVH LCRQVFCDEN GRSFAKKRFN
DHNENDLTRY KKRKFNPVSP RSQWVRAFGR IKARGRVCST GRGSDSGLSQ LSITDPHPHL
DGGNVFTIDK PDRSCASVPV HLADRVRRGL VLPCNNAFSN KHLELAYQRY SSRQKQKSLI
VVNLVDFFVK LLLLASEILQ KRESISPLNI SFSACWMFFN LVVCVLCFWR CFANNYLRQS
AVFTWLVLNI QGFSALSVGF KCDKMHQYGG IETSWYIIFI VFVTHAMLPL PLEWSVTAGS
LTAVVHLLLS TIWNSADVTF YKLIFGNVLL YLCLNLAGIY GKYLMERAQR KAFVETRRSM
ETRYKTEKET ERQEKLLLSM LPRFVAAEMI NDIIAQEEAE KKAFQPSQFH KIYIHRYENV
SILFADIKRF TELASRCTAQ ELVTLLNQLF ARFDRLANET HCLRIKLLGD CYYCVSGLPE
PRVDHAKCCV EMGLHMIKAI GSVREQTNVN VDMRIGIHSG SVLCGVLGLR KWQFDVWSND
VTMANHMESG GIPGRIHISK ATLDCLGDHY RVEPGCGHER DVYLKHHGVP TFLIVATEPK
RWTKLKRRER TRLWSLDEGL RLSAAATTRS DWMPEIPFEN FEMGQHVNVE GFDDNSDLEN
GGVAFAAGGE SMSDRVDDLI DNSIEIESNL RMRREHVNRF TLTFKDEHME TQFCRSADDV
FKSNMLTAFF IWIIGTSTHC IVMHELIIWR LIISATATTL LFVGFALVMA EEFVSMPASL
RRLSAHLTRN RNARNAFTCI FVSIICLASS IGMCLCSKHS DEPLASDCHN VSVYRTTHCF
LPNVFGHVTV CHFPQYYIYL WALSMVACAS FLQLPYLVKS SLLGAMMCLY CVLLLTVYQH
VLSSNTHCDT IDCLFDDPIV LQLFMFFYVL MYQCRLVEIT CRLDFLWKRQ TEQEASEIRL
LRHHNEHMLK NMLPVHVLVH FLSDDRNVDQ LYYQSIDSVG VLFASIPNFA EFFSEDVNRG
VECIRLLNEI IADFDELMEQ PRFKCIEKIK TIGSTYMAAS GLNPKQSDEE HAHICTLVDY
ALAIKGALKE VNRHSFNDFF LRIGISHGPL VGGVIGAKKP VFDIFGNTVN EASRMDSTGI
VDAIQVPKNT ADILGRCGYQ VEFRGSVAVK GKGHMDTYLV AGKRSPKTVA FNRQASRQPS
FAFVVYGMVQ ARRRQTSVKK SFVRRKPVDQ
//
