ID T1IN90_STRMM Unreviewed; 1047 AA.
AC T1IN90;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU362067};
DE EC=1.4.3.- {ECO:0000256|RuleBase:RU362067};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR002467-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR002467-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O2 + serotonin = (5-hydroxyindol-3-yl)acetaldehyde +
CC H2O2 + NH4(+); Xref=Rhea:RHEA:69072, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:50157, ChEBI:CHEBI:350546;
CC Evidence={ECO:0000256|ARBA:ARBA00036170};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O2 + tryptamine = H2O2 + indole-3-acetaldehyde + NH4(+);
CC Xref=Rhea:RHEA:59416, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:18086, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:57887; Evidence={ECO:0000256|ARBA:ARBA00036674};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + kynuramine + O2 = 3-(2-aminophenyl)-3-oxopropanal + H2O2
CC + NH4(+); Xref=Rhea:RHEA:59596, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:180898,
CC ChEBI:CHEBI:180899; Evidence={ECO:0000256|ARBA:ARBA00036934};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59597;
CC Evidence={ECO:0000256|ARBA:ARBA00036934};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a secondary aliphatic amine + H2O + O2 = a primary amine + an
CC aldehyde + H2O2; Xref=Rhea:RHEA:26414, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478,
CC ChEBI:CHEBI:58855, ChEBI:CHEBI:65296; EC=1.4.3.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000205};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+);
CC Xref=Rhea:RHEA:16153, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17478, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58001; EC=1.4.3.21;
CC Evidence={ECO:0000256|ARBA:ARBA00001138};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU362067};
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004362}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004362}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004362}.
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|ARBA:ARBA00005995, ECO:0000256|RuleBase:RU362067}.
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DR EMBL; JH431152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1IN90; -.
DR STRING; 126957.T1IN90; -.
DR EnsemblMetazoa; SMAR002467-RA; SMAR002467-PA; SMAR002467.
DR eggNOG; KOG0029; Eukaryota.
DR HOGENOM; CLU_291573_0_0_1; -.
DR OrthoDB; 5471885at2759; -.
DR PhylomeDB; T1IN90; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097621; F:monoamine oxidase activity; IEA:RHEA.
DR GO; GO:0008131; F:primary amine oxidase activity; IEA:UniProt.
DR Gene3D; 3.90.660.10; -; 2.
DR Gene3D; 6.10.250.130; -; 2.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001613; Flavin_amine_oxidase.
DR PANTHER; PTHR43563; AMINE OXIDASE; 1.
DR PANTHER; PTHR43563:SF11; AMINE OXIDASE [FLAVIN-CONTAINING] A; 1.
DR Pfam; PF01593; Amino_oxidase; 2.
DR PRINTS; PR00757; AMINEOXDASEF.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 2.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Catecholamine metabolism {ECO:0000256|ARBA:ARBA00022939};
KW FAD {ECO:0000256|RuleBase:RU362067};
KW Flavoprotein {ECO:0000256|RuleBase:RU362067};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362067};
KW Neurotransmitter degradation {ECO:0000256|ARBA:ARBA00022867};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU362067};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Transmembrane {ECO:0000256|RuleBase:RU362067};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362067}.
FT TRANSMEM 1010..1031
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362067"
FT DOMAIN 16..455
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
FT DOMAIN 534..970
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 1047 AA; 118152 MW; 222AAE01490334D2 CRC64;
MTTERTAQVV VIGGGISGLT AAKLLHEEKI NVIVLEAQDR VGGRTFTKRD PPRVKYVDIG
GAYVGPTQNH ILRLAKELNV ETYKINEDKP IVHMKNGARR LFENSYYPTS WNPLIILDMN
NLFRTIDQMG LEIPPEAPWK APHAEEWDHM TVRQFAKEVT WSKSVRDFLE TFININITTE
AYEASLLWFL WYVKQCGGTR RIFSVTNGGQ ERKFVGGSQQ ISERIAAKLE GRVFLKKPVV
GIKQSGGGVE ITTLDGQKFK ADFVISAIPP ILLLKIHFDP PFSALKNQLI QRVPMGSVIK
CIIYYRRNFW REKGICGESM CEGDEFPLSI TLDDTKPDGS EPAIMGFILA NKARRMTQLT
EDERKDAIAK SLVKVLGSEE ALHPVHYEEK NWMEMPYAGG CYTAMYPPGC MTKYAKVMRE
PHDRVFFAGT ETAIKWSGYM DGAASSGERA ARQILHAMGK ISTDQIWIEA PESKEVPGLP
FKNSMCERYL PSATGFVHFL GISTVGLAIV IYLCDTFSSC INCLWITYSI LRSLSAAKYL
HEAGISVIVL EARDRVGGRT LTKKDPTIKY VDLGASYVGP TQNYLLRMAK ELGVETYKVN
EEESVVHYNG TRRFFGRNGI PKFWNPIVNL DMNNLFRTLD KYGAEIPSDA PWDALHAEEW
DRMTVQQLTD QIICTGAVRD SFRTYITASV TSEAYEASAL WFLWYIRQCG GVKRIFSTTN
GGQERKFVGG SQQISERIAS RLRDRVQLQK PVVGIDQTSQ QTIVLTTLDG HKYRADYVIT
AIPPPLLLKI HFNPALPTLK NQLIQRVPMG SVFKCIVYYE KYFWRAKGMC GSALIDGDDE
HPFSFTFDDT KPDGTSPAIV GFITADKIRR LSGLNKDERK KIICQSLAKV FDTEDALNPI
HYEEKNWMEE QYSGGCYTIM YPPGCMTMYG KVLRTPFSRV YFAGTETATQ WSGYMDGAIS
AGERAAREIL HAMGKITKDK IIREEPENKE VPAIPFNNSL SEKILPSAPV FIRIISMTTF
LGVSVALCFI LHQKKLFKFP ENLFNQT
//
