ID T1IXB0_STRMM Unreviewed; 1734 AA.
AC T1IXB0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR005841-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR005841-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; JH431646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 126957.T1IXB0; -.
DR EnsemblMetazoa; SMAR005841-RA; SMAR005841-PA; SMAR005841.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_239889_0_0_1; -.
DR OrthoDB; 927694at2759; -.
DR PhylomeDB; T1IXB0; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 8.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF275; VASORIN; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00364; LRR_BAC; 11.
DR SMART; SM00365; LRR_SD22; 10.
DR SMART; SM00369; LRR_TYP; 19.
DR SMART; SM00082; LRRCT; 3.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 4.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 10.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1734
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004578940"
FT TRANSMEM 1503..1529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1559..1695
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1734 AA; 196406 MW; 7D6790B025AF595C CRC64;
MAFLRSTLTS IFILNCILRC LLQTLDSTPV NCPQMCNCDS DVLTGRATTL YLKCEIGNQT
SFFKYEPFKG KLYPLNQDAV NTKIFNEFHG LQNLYIDNLN LTTIDDNLLE TQTQIRIFSL
TGNNFSEIPP KFFRNFFEVW AVVLTNNNLK HFNLSQLPNP SKLKRIFFDG NYIQLTGDIF
NPYPSLEWLY LTRNNLSNLP QNLLYELPFL QLFDVRENIL TSIPPFFFSR SKFLKRLDLS
YNNLMSLSDS FSWGLFSLTE LMLSYNDLTS LSDSTFDCLW KVHNLTLDHN KLKLFSKFSF
SSLTNLLYMN LGHNEIEIKN LPVLPSKIII FSLSHNNIDH LLAGDWSENL NFLIDFDLSY
NNLTYVDFGQ FQSIFKSDKS NPFLATYNAI MKSSRVGTGL LINLNDNLIS EFNLQIFKNR
NKTDSISTLV NLDRNRFQKN CLCLNNSNFQ FVFDEFTCDE LSNCTEMIQG CPQHCSCLSF
EVLDCSNALL STIPTQIDFS PSILNMNFNN LSNLISLSDP EFQNLTTLQL NFCFLSTIHL
ISPSNSNQSI FSNLNQLRRL FLSRNLIVSL EKNTFEGLEN LQELDLSFNS IEYFSGELIF
NLKSLTILNL KQNKLKTLDL NPTYTHSNLQ ILNLKSNKLD ELTHSLKSLP NIIELDASYN
NISNIDDYEW PETLKIIALS NNKIKVKKNL NFPRNLKRLD LSSNQLDSFD TRNFNLKNGT
ILDLTKNRIN SVYIERSEKR NYYYQILLTE NPLNCSCDLK YFIDYVKQPR KQLLLEFPGA
LKCTGNENSK PKSIFLTQFQ SCDDQCPKDC LCLPNRHLEC TQIPYLKWNI RAPGYGGGGG
GGGGGGGGWG GGFGGGGGGG GGGGGGGGGG GGGGGGSGGG GGYYQYERNP IDDGEENLWS
SLILKNVPYQ ALTHLESLMW MNLTNLEIVS CIGSLRDFSN FKLGVKPSLV QFSLTHNEVS
YLPLELLNNA GELQSLNLSN NKISDVAFNF FVFTEKLESL DLSFNEIRKI NENLFSKLSL
LENLWINDNN IDIISVDLLG NKKNLKYLNA ANNRLIRIHP ESFIQTGLLL ELNLENNYIG
KEEVDGMHLP NTLKILNLAH NKVNQFQGNW KYLGWLERLD LSYNLITTIS IDDFRGYPDS
LTIYLTGNNI SSINYAGSLI RSGGNSLNTK PAIKLSHPIH CDCRIKWLVD CFRSQFIGHC
PVKVIGSNLT CQGPENVKNY LVKDLDKEEL TCVLGSCSVG CSCHIKSDFN VANCSYANFT
DLPALVPDAI DVLIMDGNTN VSLIGLKQNL WKHLKKLYIS FCSGLDGSQF DGLLVGNRGL
EVIWMMFNGI EHLPDTFFTG LKELREINLS GNKLKTLPSL EGLSNLESLS VSGNSLLVVD
TNVLTGLRSI KLDGLSDPHW AQLSTLILSH NRIAEIINEE IPSGLSYLTL DNNKLARPSG
WLNNFPLISS LRLSLGHNPW ICDCDNEEFR KWLLKDGKFA VTDIANVTCD NGMSLFDELC
ENFWAISGPI LITFTVILVI SIVMVSFYCK NQSAMRMWFY SKCVCLQWVL TEQEIECDKI
FDAFVSYANE DTDFVTETLV PELEGKPPHY RLCIHERDWK VGEQIVEQIE ESVLNSRRVI
IILTQNFINS MWSSLEFKTA HYHSMQEKAN RIIVIVIGEL PAKETLDSDL RMHINLNTYL
KWEDKQFWNK LRYAMPGNRK RSSGAAMTRG MDKFIMALEP TEDLETSFTT RSET
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