ID T1IZQ5_STRMM Unreviewed; 3447 AA.
AC T1IZQ5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR006740-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR006740-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
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DR EMBL; JH431723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 126957.T1IZQ5; -.
DR EnsemblMetazoa; SMAR006740-RA; SMAR006740-PA; SMAR006740.
DR eggNOG; KOG1024; Eukaryota.
DR HOGENOM; CLU_224894_0_0_1; -.
DR OMA; CHERRED; -.
DR OrthoDB; 316463at2759; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 9.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.60.40.2170; Wnt, WIF domain; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR003306; WIF.
DR InterPro; IPR038677; WIF_sf.
DR PANTHER; PTHR13817:SF73; IG-LIKE AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR13817; TITIN; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF02019; WIF; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 9.
DR SMART; SM00219; TyrKc; 1.
DR SMART; SM00469; WIF; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 9.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50814; WIF; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..155
FT /note="WIF"
FT /evidence="ECO:0000259|PROSITE:PS50814"
FT DOMAIN 284..604
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 2429..2533
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2537..2632
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2633..2718
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2719..2811
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2815..2909
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2911..3021
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3022..3115
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3116..3204
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3208..3300
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 697..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..1640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1681..1723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1891..1912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2046..2089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2130..2179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2252..2419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 875..902
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 706..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1075
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1450..1464
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1481..1509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1601
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1607..1631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1681..1709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2143..2163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2252..2270
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2277..2302
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2309..2329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2342..2363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2364..2382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3447 AA; 388283 MW; 58221C6F49340357 CRC64;
MVFGARMGTW IILLAIIVMT SANLNLFASL AEVKKLFGLP SELYYVREGV VNTYAMQFNV
LVPSHINELH FVWQNLRQQP MSYSIGFTVS NSEALGRPQM NITRKGVVPS RLSVFRIFLP
CSGQMTAEVE MKIQMNFSIS ANNVTVLNFK RKKVCLKDDF QPQNDSVVDD PSVYAAASTK
IFYIVVGCSC SLIFFIATVF GFCYIKSNKA RRNETLPDHR SSSTLCNQAH TFLRVETPTN
ATCSGTKPSY SSFRRVAPGQ LINGFQSMEL VDQLAEISIG RNKVSLKEIL HEGTFGRIYN
GILIDDIDMR TSQSVYVKTV SDQASQIQIS LLVAEGMMMY GLSHRNIQSI LAVSLEDRKQ
PLLIYPRAAL GNLKRFLQKC KFSPEGHAHV ISTREVVDMA IQITLGMQYL HRRKVIHRDL
ATRNCVLLLF RIDERLQVRI ADNALARDLF PNDYHCLGDN ENRPIKWLAL ECLISKQFYP
ASDVWAFGVT LWELMTLGQQ PYIEIDPFEV VAFLKDGYRL SQPINCPDEL DELIPPQLFG
NQPRTRRFSA SFSPNNCCTS PQSPMPFRIS QIKHEEGMDI VNREVAHERE VRSAMQMSQS
YEDLTLVETF PLESKRNGSE LFASPVSAGC SLSPTRGRKL TFSPTLQQPS PTRRIFTSKR
SISPITLRPS AFSAKRKCEL DEKDNVFSPN KRFHSLTPDR GLSVHPLTHS LSSNSLDDTA
SPEQTVPHST TVGTPESLHS NDSMCSIFKS TDQDMQLSEP PTPDTMNQHT ELVIVVKNAG
IGCELALVNM DAVVNINMGL LVVRIKRVKQ ETSKILGMKK KTRRRSKTRI HKPEPESKIK
STVVVTRPTD KERDDDDNKG KKWSNDKSHL DFQEELDLEK RRQQLQRELA LEMQKERMAQ
EREKVIIQKT VSSSSSSSDS SSSSRSSSSS SSSDDNRVNS SSSDDSTDSN AKHKNKRERL
KSGARRFVPP PKEEQTDKSG SAKKIKDKSE HPTSNKPKSQ SRRASRSPIT TSPKSKGPRT
PSPPPKHRHK SPDTADKERS ATGKSNDKYN RKKRSSSLAN DDARKTTKRW SKSPPTPELR
RSPTPAARDG GSGRKSRRGN RTPSPSSLRK TKKKSLTPDK NRKPVVNEKV EKKRTSVSKE
KDVPAPREAR SVRSYSPDRD RDRDQDRHHH ARRSLSPRED VKKMEGFRDE KDKKRRLPLR
EGFYKKGRDR REPNKTRGNK NQDRREPHNL PPRERELGEA DRKRNVDDAS RRSSPFRRGA
GSPTRHPASV EERDGIKRRQ DRDRDEKPGS GNHREERRDD NSRNKRPHGE KEALEDERKG
YQRDKAKQDG AQDSWEWNRG QGHNKSAHDG RRSTSREKRG DDVHRDHRRG FDERGLKDDV
RREREERERE RDLPAGNQVL PRGERRPKER LRDNLDKLEG GRRRMNLGKG PQMGGKEGLG
GEKGGRRRWR SNRDGRRGRG KNRTARRLRA DNPNLQPLNK EPQWKRRDEP LEPRKRPRGG
GDRLSPPAKH GRNDPSPSLR AAAWTEMPIE EQRDPPHRER ESQDWNAERK RNRENDKQED
EPPKDEGYRR REPRKRRRSR SRDDKRDEKR PRRDPSKEPS QPKANEEPPP KLEEGVVNEI
KGGHEPVAAS VDKEVDGLSD WSDDADEILN MEEEMEVKDS LVIEEEKECV EVKPERKNLL
ELIEESRGKK RSSSQEKEGR SRTRERQSYR SQPTSRNTSI ERRSTEKCGL LKDLMTLFNK
CFCFFRVSSS ASRNRSIDRN AAPPPPKEEE ILLLSDASVN KLEGSKEKES ENILENDDYE
AISDDDLETM IEEPEDEAAK LEREAKNGTV DSLEVDWSCL TARPKAKNEA APGSALRRFS
AVYLFSRIGI LPQYGGKQLL DKIKAKCEEQ LREEEEEERG NQTTGSEVEN SSKLQLTFES
SYSNSMLFAK IKDSEQKNSV LTDIGPYRRA LCARRDLQLR KQLYKVTEKI PSVTPQSFDN
EMYKLSVQLF KQRKIEQEKA IHIENPSTYL MVKTMNCSTT VHDDKQTEAK TNHIDIEAEN
LSAAGETASE TNDANANGHQ DPLIEEGTTT SRSSCRTSMP VTKDPRLDTN SAPFTIPAVF
ETCQNGNGWI TTNAFNSHFH PQMPMTPGVP YAAKCAGPHR GQSPSRYSPS PHQSRGTSPN
EATNTGAPPP PPPLPTSQHV VHLHVNPGEA ISFQVGDQMQ LIQGPATVRM VSNNTSPPIP
MPVHVPPGHM VQQIVDENGT LRHVILSPQP PMSVPMGPTP YPPGPGPNTG PTSPHFYAYP
HPYPHPPHPQ YHPHPAGPPP PAHIQAQGVT QAMHGQVPPL SSHPCNSHHS QGPSPPPPIP
QHKDERTQRQ YMKMRKKLEA RQKENSTTNI SFSCNTHLTV PPPSSFPKKD NASKKYKDGN
SSTTGSEEND ETNKEQEEES KVLIELLSKV FPPKVSEVDA RSAFLRWKPP DMSSEDENKK
NDLSIRESDF TYDVLLSDHG KDSKYRVIYS GSALEYKLTD LKPATEYHVC LEAVMDELRG
KISEAVVFKT KCCEPDIPGP PKVVNRTKTS LTLRWNPSAD NGSKVINYIL EYDEGRGDGK
FVELLRTSSK QPKISKLNAS TCYKFRVSAV NEIGRSKTSE SYACMTSGSP PSQPIPPQLK
EAHVTRLLVS WQKRPTDDEF TLQMEDEDSG HGFLPVYNGK ETLCMCSNLL RNTEYKFRLC
AINDEGASRW SDSVTYRTRP DRPGIPGKPV PKDLILLKID PPKDNGGSDI QSYTLEIDSG
NNFEPIYTGN ETEYVCDHLL AGRTYRFRVR ASSQGGLSEY SEVFAASTLA VCPGRCSVPR
LHGKPKATTL NLKWNYPEDD GGSPITEFEI EMTNPDNTSR QVYRGRDLDC MIASLLPGRP
YLFQVRAYNK VGFGPLSEPL EVVSGAGPPD RPCEPRVTFK SPHTATVSWD EPVNNGAAVT
EFRLEWSTKD GEFQQLFQGY ALNYEIKNLS PATQYNFRLR VMILVHIFMR NIKIKLCLMQ
AVNSAGSSAL SEATSCATPA SSPGAISTSS IKYTCTATSI DLTWREPASN GSNILSYNVD
LSERHLLITE GDTPKCLIDN LTPETTYKIR IQAVSSVGVG PFSSLLKICT LSLPPAPPRL
ECMRIGHNSL VIKWGEGKNA DFTHYTLEME NRAGNFVPVY QGGSLSQKIS KLMETTEYRF
RICAANDAGS GPYSDVVGFT TCKAPPPVPK PPRVTEVSET SCLVEWQQAK PVGDDVIIYQ
LQLLNLREQE FRLVYKGSEL NKRLTGLEPK TEYNVRVGAI RQCRQESDSE SAQVVEVAGA
FSSSTTFVTP SLERLRIAQT KSHSAQTVER KPLTDQQWAV IDNIQDGRTL KRTQCKVFGR
TCELTSCGVR VAKDFAGTDQ DYQRHWPGLP AALARTSSGI GQDFQRHWPG LPAALARTSS
GIGQDFQRHW PGLPAALART SPARTRT
//