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Database: UniProt
Entry: T1IZQ5_STRMM
LinkDB: T1IZQ5_STRMM
Original site: T1IZQ5_STRMM 
ID   T1IZQ5_STRMM            Unreviewed;      3447 AA.
AC   T1IZQ5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE            EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS   Strigamia maritima (European centipede) (Geophilus maritimus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX   NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR006740-PA, ECO:0000313|Proteomes:UP000014500};
RN   [1] {ECO:0000313|Proteomes:UP000014500}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA   Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA   Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA   Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA   Muzny D.M., Gibbs R.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SMAR006740-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2015) to UniProtKB.
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DR   EMBL; JH431723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 126957.T1IZQ5; -.
DR   EnsemblMetazoa; SMAR006740-RA; SMAR006740-PA; SMAR006740.
DR   eggNOG; KOG1024; Eukaryota.
DR   HOGENOM; CLU_224894_0_0_1; -.
DR   OMA; CHERRED; -.
DR   OrthoDB; 316463at2759; -.
DR   Proteomes; UP000014500; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd00063; FN3; 9.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   Gene3D; 2.60.40.2170; Wnt, WIF domain; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR003306; WIF.
DR   InterPro; IPR038677; WIF_sf.
DR   PANTHER; PTHR13817:SF73; IG-LIKE AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR13817; TITIN; 1.
DR   Pfam; PF00041; fn3; 7.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF02019; WIF; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00060; FN3; 9.
DR   SMART; SM00219; TyrKc; 1.
DR   SMART; SM00469; WIF; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 5.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50853; FN3; 9.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS50814; WIF; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          26..155
FT                   /note="WIF"
FT                   /evidence="ECO:0000259|PROSITE:PS50814"
FT   DOMAIN          284..604
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          2429..2533
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          2537..2632
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          2633..2718
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          2719..2811
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          2815..2909
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          2911..3021
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          3022..3115
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          3116..3204
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          3208..3300
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          697..741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          818..868
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          907..1640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1681..1723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1891..1912
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2046..2089
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2130..2179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2252..2419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          875..902
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        706..741
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        845..868
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        907..946
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        962..997
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        998..1016
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1026..1075
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1097..1111
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1112..1254
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1267..1332
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1342..1395
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1402..1424
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1450..1464
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1481..1509
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1530..1572
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1581..1601
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1607..1631
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1681..1709
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2143..2163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2252..2270
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2277..2302
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2309..2329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2342..2363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2364..2382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3447 AA;  388283 MW;  58221C6F49340357 CRC64;
     MVFGARMGTW IILLAIIVMT SANLNLFASL AEVKKLFGLP SELYYVREGV VNTYAMQFNV
     LVPSHINELH FVWQNLRQQP MSYSIGFTVS NSEALGRPQM NITRKGVVPS RLSVFRIFLP
     CSGQMTAEVE MKIQMNFSIS ANNVTVLNFK RKKVCLKDDF QPQNDSVVDD PSVYAAASTK
     IFYIVVGCSC SLIFFIATVF GFCYIKSNKA RRNETLPDHR SSSTLCNQAH TFLRVETPTN
     ATCSGTKPSY SSFRRVAPGQ LINGFQSMEL VDQLAEISIG RNKVSLKEIL HEGTFGRIYN
     GILIDDIDMR TSQSVYVKTV SDQASQIQIS LLVAEGMMMY GLSHRNIQSI LAVSLEDRKQ
     PLLIYPRAAL GNLKRFLQKC KFSPEGHAHV ISTREVVDMA IQITLGMQYL HRRKVIHRDL
     ATRNCVLLLF RIDERLQVRI ADNALARDLF PNDYHCLGDN ENRPIKWLAL ECLISKQFYP
     ASDVWAFGVT LWELMTLGQQ PYIEIDPFEV VAFLKDGYRL SQPINCPDEL DELIPPQLFG
     NQPRTRRFSA SFSPNNCCTS PQSPMPFRIS QIKHEEGMDI VNREVAHERE VRSAMQMSQS
     YEDLTLVETF PLESKRNGSE LFASPVSAGC SLSPTRGRKL TFSPTLQQPS PTRRIFTSKR
     SISPITLRPS AFSAKRKCEL DEKDNVFSPN KRFHSLTPDR GLSVHPLTHS LSSNSLDDTA
     SPEQTVPHST TVGTPESLHS NDSMCSIFKS TDQDMQLSEP PTPDTMNQHT ELVIVVKNAG
     IGCELALVNM DAVVNINMGL LVVRIKRVKQ ETSKILGMKK KTRRRSKTRI HKPEPESKIK
     STVVVTRPTD KERDDDDNKG KKWSNDKSHL DFQEELDLEK RRQQLQRELA LEMQKERMAQ
     EREKVIIQKT VSSSSSSSDS SSSSRSSSSS SSSDDNRVNS SSSDDSTDSN AKHKNKRERL
     KSGARRFVPP PKEEQTDKSG SAKKIKDKSE HPTSNKPKSQ SRRASRSPIT TSPKSKGPRT
     PSPPPKHRHK SPDTADKERS ATGKSNDKYN RKKRSSSLAN DDARKTTKRW SKSPPTPELR
     RSPTPAARDG GSGRKSRRGN RTPSPSSLRK TKKKSLTPDK NRKPVVNEKV EKKRTSVSKE
     KDVPAPREAR SVRSYSPDRD RDRDQDRHHH ARRSLSPRED VKKMEGFRDE KDKKRRLPLR
     EGFYKKGRDR REPNKTRGNK NQDRREPHNL PPRERELGEA DRKRNVDDAS RRSSPFRRGA
     GSPTRHPASV EERDGIKRRQ DRDRDEKPGS GNHREERRDD NSRNKRPHGE KEALEDERKG
     YQRDKAKQDG AQDSWEWNRG QGHNKSAHDG RRSTSREKRG DDVHRDHRRG FDERGLKDDV
     RREREERERE RDLPAGNQVL PRGERRPKER LRDNLDKLEG GRRRMNLGKG PQMGGKEGLG
     GEKGGRRRWR SNRDGRRGRG KNRTARRLRA DNPNLQPLNK EPQWKRRDEP LEPRKRPRGG
     GDRLSPPAKH GRNDPSPSLR AAAWTEMPIE EQRDPPHRER ESQDWNAERK RNRENDKQED
     EPPKDEGYRR REPRKRRRSR SRDDKRDEKR PRRDPSKEPS QPKANEEPPP KLEEGVVNEI
     KGGHEPVAAS VDKEVDGLSD WSDDADEILN MEEEMEVKDS LVIEEEKECV EVKPERKNLL
     ELIEESRGKK RSSSQEKEGR SRTRERQSYR SQPTSRNTSI ERRSTEKCGL LKDLMTLFNK
     CFCFFRVSSS ASRNRSIDRN AAPPPPKEEE ILLLSDASVN KLEGSKEKES ENILENDDYE
     AISDDDLETM IEEPEDEAAK LEREAKNGTV DSLEVDWSCL TARPKAKNEA APGSALRRFS
     AVYLFSRIGI LPQYGGKQLL DKIKAKCEEQ LREEEEEERG NQTTGSEVEN SSKLQLTFES
     SYSNSMLFAK IKDSEQKNSV LTDIGPYRRA LCARRDLQLR KQLYKVTEKI PSVTPQSFDN
     EMYKLSVQLF KQRKIEQEKA IHIENPSTYL MVKTMNCSTT VHDDKQTEAK TNHIDIEAEN
     LSAAGETASE TNDANANGHQ DPLIEEGTTT SRSSCRTSMP VTKDPRLDTN SAPFTIPAVF
     ETCQNGNGWI TTNAFNSHFH PQMPMTPGVP YAAKCAGPHR GQSPSRYSPS PHQSRGTSPN
     EATNTGAPPP PPPLPTSQHV VHLHVNPGEA ISFQVGDQMQ LIQGPATVRM VSNNTSPPIP
     MPVHVPPGHM VQQIVDENGT LRHVILSPQP PMSVPMGPTP YPPGPGPNTG PTSPHFYAYP
     HPYPHPPHPQ YHPHPAGPPP PAHIQAQGVT QAMHGQVPPL SSHPCNSHHS QGPSPPPPIP
     QHKDERTQRQ YMKMRKKLEA RQKENSTTNI SFSCNTHLTV PPPSSFPKKD NASKKYKDGN
     SSTTGSEEND ETNKEQEEES KVLIELLSKV FPPKVSEVDA RSAFLRWKPP DMSSEDENKK
     NDLSIRESDF TYDVLLSDHG KDSKYRVIYS GSALEYKLTD LKPATEYHVC LEAVMDELRG
     KISEAVVFKT KCCEPDIPGP PKVVNRTKTS LTLRWNPSAD NGSKVINYIL EYDEGRGDGK
     FVELLRTSSK QPKISKLNAS TCYKFRVSAV NEIGRSKTSE SYACMTSGSP PSQPIPPQLK
     EAHVTRLLVS WQKRPTDDEF TLQMEDEDSG HGFLPVYNGK ETLCMCSNLL RNTEYKFRLC
     AINDEGASRW SDSVTYRTRP DRPGIPGKPV PKDLILLKID PPKDNGGSDI QSYTLEIDSG
     NNFEPIYTGN ETEYVCDHLL AGRTYRFRVR ASSQGGLSEY SEVFAASTLA VCPGRCSVPR
     LHGKPKATTL NLKWNYPEDD GGSPITEFEI EMTNPDNTSR QVYRGRDLDC MIASLLPGRP
     YLFQVRAYNK VGFGPLSEPL EVVSGAGPPD RPCEPRVTFK SPHTATVSWD EPVNNGAAVT
     EFRLEWSTKD GEFQQLFQGY ALNYEIKNLS PATQYNFRLR VMILVHIFMR NIKIKLCLMQ
     AVNSAGSSAL SEATSCATPA SSPGAISTSS IKYTCTATSI DLTWREPASN GSNILSYNVD
     LSERHLLITE GDTPKCLIDN LTPETTYKIR IQAVSSVGVG PFSSLLKICT LSLPPAPPRL
     ECMRIGHNSL VIKWGEGKNA DFTHYTLEME NRAGNFVPVY QGGSLSQKIS KLMETTEYRF
     RICAANDAGS GPYSDVVGFT TCKAPPPVPK PPRVTEVSET SCLVEWQQAK PVGDDVIIYQ
     LQLLNLREQE FRLVYKGSEL NKRLTGLEPK TEYNVRVGAI RQCRQESDSE SAQVVEVAGA
     FSSSTTFVTP SLERLRIAQT KSHSAQTVER KPLTDQQWAV IDNIQDGRTL KRTQCKVFGR
     TCELTSCGVR VAKDFAGTDQ DYQRHWPGLP AALARTSSGI GQDFQRHWPG LPAALARTSS
     GIGQDFQRHW PGLPAALART SPARTRT
//
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