ID T1J083_STRMM Unreviewed; 795 AA.
AC T1J083;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=acetyl-CoA C-acyltransferase {ECO:0000256|ARBA:ARBA00024073};
DE EC=2.3.1.16 {ECO:0000256|ARBA:ARBA00024073};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR006925-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR006925-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982}.
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DR EMBL; JH431734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1J083; -.
DR STRING; 126957.T1J083; -.
DR EnsemblMetazoa; SMAR006925-RA; SMAR006925-PA; SMAR006925.
DR eggNOG; KOG1007; Eukaryota.
DR eggNOG; KOG1392; Eukaryota.
DR HOGENOM; CLU_353491_0_0_1; -.
DR OrthoDB; 1826604at2759; -.
DR PhylomeDB; T1J083; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 113..154
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 206..248
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 374..645
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 653..792
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT REGION 293..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 87513 MW; 76B1ED4E41179131 CRC64;
MEDDAAVIYG LEFQSRALTA QTAETEAIRF LVGTQSLKCD NQVHQVEFDE ENNLINKNVF
MHKEGEVWHI MTSGKCEMFS TIWQMPNDYE VNNVSDESTL TPPSLELLTK LNVSNHGTEV
KCVLWQPGDG NTVISLVDNN ILVWDLLQSS TEAKLTTKCG LEIRGHPKFT TGRWNPHHNC
TQIATANESC IRGWDLRTMQ QVYTIENAHG QLVRDLDFNP NKQYYLASCG DDCKTKFWDV
RNTKEPVLIL SDHSHCIRYN HFHDQLVLTS SSDSRVILSS IVSISSEPFG HLLEDEADDG
SQSPKTIGNG DKPQDRVIST YEEHEESVYA AEWSSADPWL FASLNSIRCV STSNIIDARA
KTKPSLAQQG RKNIVFVDGV RTPFLQSLTD YANMMPHDLA RNALLGLIKK TNLPRDAVDY
IIFGTVIQEV KTSNVAREAA LGAGFSDKIP AHTVTMACIS SNQAITTAIG LMQAGMCDSV
VAGGVEFMSD VPIRFSRKLR KIMLNMNKAK TMGARLNVLS QFRPGLLAPE LPAVAEFSTN
EVMGHSCDRL AAAFAVSRRE QDEFAMRSHK LAHEAAGNGL LSDIIPVKVP GKEKLISVDN
GIRVSTAEQM AKLKPAFIKP HGTVTAANAS FLTDGASASL IMTEEKAKAL GFKPKAYLRD
FVYVSQDPKD QLLLGPSYAT PKVLERAGLT MSDIDVFEFH EAFAGQILAN FKAMDSDYFA
QNHMGRSAKV TAPPMEKFNL WGGSLSIGHP FGATGVRLVS HTANRLIKEN GQYGLIAACA
AGGQGVAMLI ERYPQ
//
