ID T1J3Y5_STRMM Unreviewed; 554 AA.
AC T1J3Y5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase {ECO:0008006|Google:ProtNLM};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR008311-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR008311-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
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DR EMBL; JH431832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1J3Y5; -.
DR STRING; 126957.T1J3Y5; -.
DR EnsemblMetazoa; SMAR008311-RA; SMAR008311-PA; SMAR008311.
DR eggNOG; KOG2283; Eukaryota.
DR HOGENOM; CLU_020105_3_0_1; -.
DR OMA; THGGVEN; -.
DR OrthoDB; 5477362at2759; -.
DR PhylomeDB; T1J3Y5; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14510; PTP_VSP_TPTE; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR045102; PTP_VSP_TPTE.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR12305; PHOSPHATASE WITH HOMOLOGY TO TENSIN; 1.
DR PANTHER; PTHR12305:SF60; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 104..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 223..399
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 308..353
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 406..539
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
SQ SEQUENCE 554 AA; 64425 MW; 5332BFC28324E785 CRC64;
MPIVKAHTKP TYKRFDTYVT PDFTDDLEKN NWNDNSVAID VMGSKEKKDE TDDEDDIDED
IEDPFSYDAH ALHNTIDPVA VAEPLPTTCF GKFRLKLENV VEHFIFRLFG LILIVIDICI
LIVELVKIQD DNLEEQKPYE IVSLTFVCYF VLEVTLRIIA LGANRFFRQW FNVIDFIVVF
TAFIITLISA VIDLIDLSGI YKLFTAKKHV EKGARHMVSQ NKRRYQEDGF DLDLTYVTDR
VIAMSFPSAG KMSCYRNPIK EVARFFNTKH PDHYKVYNLC SERTYDDQYF HGRVERYLVD
DHNVPLLEDM VRFARSVRTW LDSHPLNVIA VHCKGGKGRT GTMICIWLVE SGLFESAGDS
LDYFGFRRTD LNISNKFQGV ETPSQSRYVG YYEDIKDKLN GQMPEERALK IKMLRITALA
GLGKGDGSDF SCEIFIGRNN KIFECNFGLN KNCQTHYYNE ADYLEVKLTN CPNLVGDVKM
KEIFLEDMKK LPFYLWFYTS FIENGSLLIK RNDLDNPHKP KTWQWFREKF SIEIIFETTI
NEENVGNCQK QMDP
//
