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Database: UniProt
Entry: T1JEU7_STRMM
LinkDB: T1JEU7_STRMM
Original site: T1JEU7_STRMM 
ID   T1JEU7_STRMM            Unreviewed;      1942 AA.
AC   T1JEU7;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   07-JUN-2017, entry version 29.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Strigamia maritima (European centipede) (Geophilus maritimus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX   NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR012350-PA, ECO:0000313|Proteomes:UP000014500};
RN   [1] {ECO:0000313|Proteomes:UP000014500}
RP   NUCLEOTIDE SEQUENCE.
RA   Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P.,
RA   Goodspeed R., Gross S., Mandapat C., Jackson L., Mathew T., Pu L.,
RA   Thornton R., Saada N., Wilczek-Boney K.B., Lee S., Kovar C., Wu Y.,
RA   Scherer S.E., Worley K.C., Muzny D.M., Gibbs R.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SMAR012350-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (FEB-2015) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; JH432130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; SMAR012350-RA; SMAR012350-PA; SMAR012350.
DR   OMA; YMIDEDH; -.
DR   PhylomeDB; T1JEU7; -.
DR   Proteomes; UP000014500; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000014500};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    133    159       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    207    228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    264    283       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    395    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    764    782       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    794    817       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    882    908       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    928    947       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    959    985       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1233   1251       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1272   1288       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1294   1314       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1321   1342       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1424   1450       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1511   1528       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1540   1562       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1574   1593       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1627   1655       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1727   1750       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1767   1802       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    1780   1791       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED      421    451       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1942 AA;  221229 MW;  47FF718C4771A509 CRC64;
     MSESEVVGSS RPQFRPFTRE SLAGIEERIA ADAEIKHQHK LHPESEEGEK HRDDDEGSED
     QGPEANLEAG MPLPLYMQHN FPPELIATPI EDIDKFYHNQ RTFVVVSKGK DIFRFSAHKA
     LWLMDPFHPV RRIAIYVLVH PIFSMVVITT ILINCILMTQ PTSPFAEDSE NYFTAIYTFE
     SVTKMLARGF ILDKFTYLRD PWNWLDFAVI ALAYVTMSLG EVLGNLAVLR TFRVLRALKT
     VAIVPGLKTI VSAVIESVKN LKDVIILTVF SLSVFALFGL QVYMGCLRQK CVVTLPEEHL
     WNMSESAIKS FRNNDSNWYY KKNFDEPLVC GNASGATECP DGFTCYEKIG DNPNYGYTSF
     DSFGWALLSA FRLMTQDFWE DLYQLVLRSM GPMHMLFFIF IIFLGSFYLV NLILAIVAMS
     YDELQKRAEL EEQEEQEILK MIEEENRLAA EGHAGGGGGG GGGGYSPVMS SNGELFLGQL
     VEDANKPMDK ISLQSDGGDS IADQKGRPNG KVRKQQKRCS LCLQGSLSLP GSPFTLRRGS
     RGSHQFNWRT NGRRYGDKKP LVLSTFLDAQ EHLPYADDST AVTPMSEENG AIIIPGYAIL
     NSRHNSYTSH CSRGSYTSHG DLNAKAFTKE NQLRTRRNLQ SLVPDVMDPR PEFESSVDSE
     DFLSKHKHCD NPFIDQIPTN PALDMKDVMV LNDIIEQAAR NSRGSEHGVS IYYFPTDEEE
     DGPKWKERVV AKCLKCIDIF CVWNCCACWV KFQEYLCLFV YDPFVELFIT LCIVVNTLFM
     AMDHHEMPDE MVEFLANGNY FFTATFAIEC GMKLVAISPK NYFKEGWNIF DFFIVALSLV
     ELSLEGVKGL SVLRSFRLLR VFKLAKSWPT LNMLISIMGK TVGALGNLTF VLGIIIFIFA
     VMGMQLFAEN YRLKAHMFHG KVTPRWNFVD FLHSFMIVFR VLCGEWIQSM WDCLVVNETI
     CLPFFLATVV IGNLVVLNLF LALLLSSFGA SNLTNAPVDS DTNKLAEAID RINRFVAWIK
     RSVRNTFSRA VKAIRAKMTN QIADQTADRD ADTEDGGEIL ADGQIIMRDK KSDETLIKNK
     KKEIIANNKP LCNSVKKVDD NKEREHLENH LLCRQNKEKS EESLSNESYI SKTHTTSSRR
     SSAASGASEG EEKKDIEKEE GDEVEEVNEE QEMGEEEAVE QKVQEGEEPK VPFICCLDIC
     YDKIPWCAGK DTPFWDGWYN LRLQTLLLIE NKYFETVVIT CILISSMALA LEDKYINHKK
     ILKESLIYMD RVFTVLFFFE MLIKWLALGF RKYFTNAWCW LDFIIVLVVV NALVQAIPSI
     FNVLLVCLIF WLIFSIMAVQ LLGGKFFKCI NEENEKINAS IISNKTECER ANYTWKNSKI
     NFDNVANGYL ALFQVATFKG WIEILEDATD AKEKYHQPDY EANVYIYLFF VFFIIFGSFF
     TLNLFIGVII DNFNEQKKKA GGSLEMFMTD DQKKYYNAMK KMGSKKPAKA IPRPRFRPQA
     IVFDITTDKK FDMFIMVFIG LNMIVMATDH YGQTDEFKEI VTGLNTVFIA VFTSECCLKI
     FALRCYYFKE PWNMFDFVVV ILSILGVALK EMIENYFVSP TLLRVVRVVK VGRVLRLVKG
     AKGIRTLLFA LAMSLPALFN ICLLLFLVMF IYAIFGMSFF KTVKYGNGLD ETFNFNTFPQ
     SMILLFQMST SAGWDGVLDP LMNEENCTLP DINLDEEGNC GNSGKAVVFL ISYLVISFLI
     IINMYIAVIL ENYSQATEEV QEGLTDDDYD MYYEIWQRFD PDGTQYLTYE DLPEFLHELE
     EPLQIVKPNK YKIISMDIPI CKNDLLYCVD ILDALTKDFF ARKGNPIEEA GDLGEVVKTD
     RPGYEVISST LWRQREEFCA RLIQKAWRKH RGKAHSTSSA ADGPELQQTS IVIESDGHVT
     KNGHKVVIHS RSPSVTSRST DV
//
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