ID T1JJU0_STRMM Unreviewed; 772 AA.
AC T1JJU0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR014120-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR014120-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR EMBL; JH431714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1JJU0; -.
DR STRING; 126957.T1JJU0; -.
DR EnsemblMetazoa; SMAR014120-RA; SMAR014120-PA; SMAR014120.
DR eggNOG; KOG3667; Eukaryota.
DR HOGENOM; CLU_014189_2_2_1; -.
DR OMA; WIEEKMW; -.
DR OrthoDB; 7823at2759; -.
DR PhylomeDB; T1JJU0; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09919; SH2_STAT_family; 1.
DR CDD; cd16855; STAT5_CCD; 1.
DR CDD; cd16849; STAT5_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR046994; STAT5_CCD.
DR InterPro; IPR035858; STAT5a/5b_DBD.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF43; SIGNAL TRANSDUCER AND TRANSCRIPTION ACTIVATOR; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 604..699
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 728..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 88013 MW; AFB5F29ABFD32444 CRC64;
MGLHQENRYC GSEMSLWTKA QQLQGDALRQ VQAVYGDHFP IEVRHFLAPW IEEKTWQNID
PDNPAHEGYA AGLVASLIQE LEAKAQQMNS AEFFLMKLKL SETANMFRQH YSHNPLSLVR
IVRHCLNMET KLVEQAENPP VGSGMANQIH STLDPQQEIT QQLEYARRKT HETEEELRRM
QNEQESFVIQ YQESSKLQAH INQVRGQPNG QTQVETEKKL QKQKEMVDQM LSQKATGLLQ
MRLALAEKHN ETFQILNGLQ SKVLDEELIR WKREQQLAGN GAPFNNNLDT IQEWCEALAE
VIWQNRQQIK RVELLRAQLP IDPPGGVDLL PGLNSQITGL LSSLVTSTFI IEKQPPQVMK
TNTRFTATVR LLVGGKLNVH MTPPQVKVTI ISEAQANALL KNDKMAKGDA SGEILNNNGT
MEYHQATRQL SVSFRNMQLR KIKRAEKKGT ESVMDEKFSL LFQSQFNVGG GELVFQVWTL
SLPVVVIVHG NQEPHAWATV SWDNAFAEPG RVPFAVPEKV PWQQVAEMLV CKFKAATGRG
LSDDNLRYLG GKAFRSNTQI QEYANMMLSW SQFCKETIPD RTFTFWEWFY AIMKLTREHL
RGLWNDGHIL GFLGRKQTEE MLLSKCKGTF LLRFSDSELG GVTFAWCNSE GQNPEQKEVL
MLQPFSNKDF AIRSLADRAN DMGFLQYLFP DVAKDKAFSK YYTPMTENAT NFNGYVKPVL
RTHVPGVEEN GMESYPSTPQ QLQPQSPDTG YLRDTPSVNS NASEHMTDQH YM
//
