ID T1JLT2_STRMM Unreviewed; 1019 AA.
AC T1JLT2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR014812-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR014812-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; JH431465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1JLT2; -.
DR STRING; 126957.T1JLT2; -.
DR EnsemblMetazoa; SMAR014812-RA; SMAR014812-PA; SMAR014812.
DR eggNOG; KOG1215; Eukaryota.
DR eggNOG; KOG2087; Eukaryota.
DR HOGENOM; CLU_006130_2_0_1; -.
DR OMA; GVYFIHD; -.
DR OrthoDB; 2913881at2759; -.
DR PhylomeDB; T1JLT2; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15137; 7tmA_Relaxin_R; 1.
DR CDD; cd00112; LDLa; 8.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF77; GPR INSULIN LIKE RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF13855; LRR_8; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 10.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 7.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 660..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 834..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 880..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 676..932
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT DISULFID 15..27
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 22..40
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 111..123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 118..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 130..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 185..197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 192..210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 293..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 300..318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 312..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 332..344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 339..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 351..366
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 371..383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 378..396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 390..405
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 412..424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1019 AA; 116107 MW; 6096DD6A59D59117 CRC64;
VRANELASTN LSELCPQDEF FCTVNVCIPK NLKCNGITEC SNGKDESDAC QMSFFAMILA
LMRFCVKCLC AHIPTLNAIT TFVFLETRFA ILSMTVEITR TNKTVVMHRA CWFGEFSCNN
GQCIQAALLC DGNRNCLDGS DENQCDIELD YVRCSDQSLI HRYFWCDEWP DCKDNHADEL
NCRNCSLDEF QCSNTRCIKF ANVCDMVCDC AYTCEDENNC QGQYKIINTV LSWMPHNLTT
VHALDIPICD SKSTYFCPKT TRCIHKTFIC NSKNDCETNG ESSDEFGCIY DNCSNNFIIC
DDGRCLPDFV QCDFIKHCTD GLDEKDCDFP SCTKKEFRCL NGQCIKEELK CDAAYDCYDR
SDEIDCHSKK CPLGFYQCLT GQCIQSSWNC DFHVDCPDGS DEARCEHVLK KCIDTEFQCN
NGQCIPKQLV CYETGNEHSG CADGSHLLNC RNWKCPEHLH KCLNSYCIHT SRVCNGQVDC
WGSWNDEIGC PFQCSSEKQC ECSDITINCT KIGLKNLPND IEKEISKLDL SNNSIETIWP
YTFKHLWRLR ILYVEFIAKY LQDNKIDKIY NGSFFGLANV ATLDLSINYI KIMGSNVFHG
LTDLQYLYVQ NMFNNINGSC PIIANLMTDE FRFCCLARLT PNCLPQADEF SSCEDLMSNI
VLRICIWILG FIAFIGNILV IIWRLIYKIN YRVHSFLITN LAIADMCMGI YLLIIAAVDA
KYRGVYFIYD SLWRTSKLCQ FAGFISTFSS ELSVLTLTII TLHRFIGIAF PFHFQQLQMN
HTRLVVIILW GIVIVLAGVP LLHMDYFKYF YGRSGVCLAL HITSEKPSGW EYSVFIFLVL
NLMSFTIISA AYIWMFLIAK NSQKSFRTQE AKWDKTMAKR MSLIVFTDFC CWMPIIILGF
MSLSKVTIPP QVFAWIAVFI LPLNAAINPV LYTLSTPSFV KPATKSAWST RPNISNIETS
KTNILASPCD DFNLSSKQHV GDAEIVPLKI LHTHSYEKGS SLKHFIPNVT KDNSNPLYD
//
