ID T1KSM5_TETUR Unreviewed; 637 AA.
AC T1KSM5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:tetur20g00140.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur20g00140.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur20g00140.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR EMBL; CAEY01000505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1KSM5; -.
DR STRING; 32264.T1KSM5; -.
DR EnsemblMetazoa; tetur20g00140.1; tetur20g00140.1; tetur20g00140.
DR eggNOG; KOG3577; Eukaryota.
DR HOGENOM; CLU_007873_2_1_1; -.
DR OMA; NCAIPCY; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd07456; CRD_FZ5_like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF126; FRIZZLED-2; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 279..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..170
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 277..570
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 171..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 54..115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 62..108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 99..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 126..167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 130..154
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 637 AA; 72085 MW; 14CEAA2697F4917D CRC64;
MNNLISEISV YQCELAVNHS ASIDIKMHFF TLFIYILFVP SILTSTESDG RSKCEEITVP
MCRGIGYNMT SMPNQFHHEK QDEAGMEAHQ FWPLVEISCS DDLRFFLCSM YTPICMEDYT
ERLPVCRSVC ERAQAGCAAI MLQYGFPWPE SMDCNNFPVF GSQEQLCMDH KNGETPGPGT
VSTQASIPSK PPPPHYPSTT FYSLSTAPTS TIYPTFNSST KNVDITGSRC HCECKPPMIS
INVQSDYYNH INERGVIDCA QPCHTNLFFT KQEQSKSSLM ITIAAFSCLL GSIMVIFTYL
TGRERFCYPE RSIIFLSACY LIVSIGFLYP KLTNSETIAC DSDKLLYAGF GTPTWNCTFV
FILIYFFSMA ASLWWIILTF SWFLSASLKW TVEIINDYSI YFHFIAWSIP AVKSYLAITM
KAIDGEPLAG ICLVGNLNSQ LLVRFIIAPL CAYLIVGVFF LLAGLFSILR IRKSIRKQIR
QINDKCGLDK LMVRIIIFSI LHIVPILVVI ACNYYQYSHG SIWEPYHHCL CNPYRLETPY
VTIHLVKYIM LLVPGITTCF WILSGKTLES WWNFLAQKFC CCLTIAPPNP RGQLIGSTSG
GSSQYIVNSQ RSYKQINHIA QLSASGQPHR KISLSHV
//
