ID T1KTW9_TETUR Unreviewed; 752 AA.
AC T1KTW9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
GN Name=107367356 {ECO:0000313|EnsemblMetazoa:tetur21g01290.1};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur21g01290.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur21g01290.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; CAEY01000548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015790541.1; XM_015935055.1.
DR AlphaFoldDB; T1KTW9; -.
DR STRING; 32264.T1KTW9; -.
DR EnsemblMetazoa; tetur21g01290.1; tetur21g01290.1; tetur21g01290.
DR GeneID; 107367356; -.
DR KEGG; tut:107367356; -.
DR eggNOG; KOG1215; Eukaryota.
DR HOGENOM; CLU_008163_4_0_1; -.
DR OrthoDB; 2876235at2759; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00192; LDLa; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 7.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..752
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007729067"
FT DOMAIN 245..260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT DOMAIN 288..303
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT DISULFID 26..38
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 33..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 45..60
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 78..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 90..105
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 136..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 192..210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 657..672
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 697..712
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 716..728
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 723..741
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 735..750
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 752 AA; 84246 MW; CDD11CE9752B2A5D CRC64;
MAVTLFSSVA LLLCCQLVTS SVTVGCLKNE YLCPTGACID KLMVCDGYVD CPGYYDELNC
TKSNISRSLN DSCSGFVCKN SACLPRHKVC DGNGDCPYDE DELNCVPDDM VCLKDCGYNE
AENVTFELCI SNASICDGVA DCYDGLDETN CSKIKSSNES KSFSTSRNYN RRRLSQDNST
FIDCGEPNAF DCGDGKCIDK NLTCNRKFDC LGGQDEHDFC DKTPCEAKLC SHYCVFNKSN
NGSKCICSDG YQLLPDGLTC EDIDECTLDP FKRPCTHECT NTLGSYRCSC FEGFTSAIEY
GFCVPITKKN RCAISAKESY LLTLKDGHIF LRYFKCITDQ SPIIVANVTS KVSTFTYDRS
SRNIYTYDVA QKSINLIHFN NDTIQFLQLE NSTRDLNSLT YDDLTGNLYW IEPFPGLLKI
ISTKDPNKTI ITLSGGLQDA NSLALYQERG EMYISMIGSE PKIVVYDLKG EDIRQVDESG
SSIHPSSLFV DKFSKRLFWS DFGYQEVYYV SLDGRRGDFG PKEVVHRSTH KIRSMVVYDY
KMYLATDNLF IQVDLYDVLS QKEIKKLDSL KERSLIHNDF YVHCSVDFNY RNPCLNDGRG
NCSHVCTFID STVHCLCPHR MVLDQTKRKC ETKNISCSSG EILCKDGLNC YKESKKCDGH
KDCDDGSDEL DCVTSDCPEG HAKCLDTSKC IPKKWFCDSY LDCSDGSDEK DCAQTCNHGD
FNCNASQCIP GSWVCDGIPD CDNGSDEKNC LY
//
