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Database: UniProt
Entry: T1L2Z6_TETUR
LinkDB: T1L2Z6_TETUR
Original site: T1L2Z6_TETUR 
ID   T1L2Z6_TETUR            Unreviewed;      2199 AA.
AC   T1L2Z6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-SEP-2017, entry version 33.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=107369731 {ECO:0000313|EnsemblMetazoa:tetur34g00970.1};
OS   Tetranychus urticae (Two-spotted spider mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Acari; Acariformes; Trombidiformes; Prostigmata; Eleutherengona;
OC   Raphignathae; Tetranychoidea; Tetranychidae; Tetranychus.
OX   NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur34g00970.1, ECO:0000313|Proteomes:UP000015104};
RN   [1] {ECO:0000313|EnsemblMetazoa:tetur34g00970.1, ECO:0000313|Proteomes:UP000015104}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=London {ECO:0000313|EnsemblMetazoa:tetur34g00970.1};
RA   Rombauts S.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:tetur34g00970.1}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CAEY01000993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CAEY01000994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015793195.1; XM_015937709.1.
DR   UniGene; Tur.2679; -.
DR   EnsemblMetazoa; tetur34g00970.1; tetur34g00970.1; tetur34g00970.
DR   GeneID; 107369731; -.
DR   OMA; YMIDEDH; -.
DR   Proteomes; UP000015104; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   PANTHER; PTHR10037:SF229; PTHR10037:SF229; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000015104};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    134    160       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    202    219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    263    283       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    390    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    785    809       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    830    853       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    859    880       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    918    941       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    984   1015       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1510   1531       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1559   1588       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1681   1704       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1765   1782       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1794   1816       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1828   1844       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1881   1909       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1929   1955       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1976   2000       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     2017   2052       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    2030   2041       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   2199 AA;  249142 MW;  DF474663E494DA99 CRC64;
     MSSGDLGYAD VPQKQLFRPF TRESLAAIEA RMAEKKQNEK EEKITGVDEL YVPHREEEEL
     HPDESLEAGR ILPKYLERGF PPDLIGTPIE DLDKYYEKAG IPTFVVVSKG KDIFRFSATK
     ALFILSPFNP IRRVAIFMLV HPWFSFLVIV TILVNCILMT MQSSEIERTE IIFTTIYTFE
     SCLKVTARGL ILTNFTYLRD PWNWLDFVVI ALAYLTMLFE DLGNLSALRT FRVLRALKTV
     AVVPGLKTIV GALIEAAKNL KDVTILTCFS LSVFALLGLQ IYMGALTQKC ILHGPSNMTT
     EEWFDWCNDR SHWLNTSSGD PILCSNTSGA TLCNSSLSTC IQGFGPNPNY GYTNYDTFPW
     ALLNAFRLLT QDYWESLYQM ILRTTSPWHI IYFIGAIFLG SIYLVNLILA IVAMSYDELQ
     KKLVDEDLAA AAEEAAYQDT LRQAEVDDGR SVGPPAGSGP ALVDSVAGLM GMNDMPTNGN
     LLSHPSPQHT FHPMGSSILP LHLDPLARRE SDAPPSPSVY SDYDDKVGDE RDRVSIKSTE
     ESNPNYDFRG GRINGKVRKA SLSLPGSPYN LRRGSRGSQF SVTWARNNAR RVGDRKPLVL
     QTFLDAQEHL PYADDSAAVT PMSEENGAIV IPVYTNLHSR HSSYTSHSSR ISYTSHGDIY
     GRGIPWTKES QLLSRRNLQG FFQEDMYAQG DDIGSALMKR QLENPFIDPQ QTPRHTAVDI
     KDVMVLNDII DQAAGRQSKS SERDKEDCEE EKPSCKQQFT TSCLKAIDVL CVWDCCWCWV
     RIQELFALIV FDPFMELFIT LCIVVNTLFM AMDHHDMDPD FENVLKTGNL FFSATFAIEA
     FMKLIAISPK FYFREGWNVF DFIIVALSLL EIFLEGVRGL SVLRSFRLLR VFKLAKSWPT
     LNLLITIMGK TLGDLGNLTF VLAIIVFIFA VMGMQLFGAN YSKKVYLFPN AEIPRWNFKD
     FMHSFMIVFR VLCGEWIESM WSCMLVCGFV CVPFFLATVI IGHLVMLNLF LALLLSSFGA
     SNLSSPTSES ADTKKLQEAF DRFGRAHKWL KNRILTGLKQ LRSKTRNQIR DTAQWPGRGG
     ASSGGMVGRS MMLGSESVLD EGDIIMMDGL NASGLIRDKK LLAAAAYGET VVGPDGLEYS
     LTESGKVTLK SSAQTVLNSV KLSQAVKDLS SDKLILTESA LIEKLSPSVT NHSDEGNRLH
     GDVSTVNNNN VNDRSTSLNN TNFNNSLNSN NLLVSASTIN NNNVNKVKPS LHDANGCSPF
     PLDDNHHHHH LVQQQPHGGD YHGESGYYGS SESQQHLVNN NVSNNNDSSA QQSSSLSVTP
     SHHLNHPSSH PTAHHYNASQ LSKVHPAGGP VPISFQHSYS SLNRLAPSPL NHFNGPGEDV
     MGEEMNANKM VTVTADVNIN DHPDDCLPEY WYHRFPCCLE ETAFWIKWRE VRSKCYKLVE
     DKYFETLVIT LILISSMTLA LEDVNLKERP WLEYSLKYID QFFTIIFTCE MLLKWFAYGF
     KSYFSNAWCW LDFIIVMVSA LNLGAEFAGL AKIQAFKTMR TLRAFRPLRA MSRSKGMRVV
     VNALIQAIPA IFNVLLVCLI FWLIFAIMGV QLFAGKFSYC RDRNTEEKSD PNEIENKTIC
     DQHNETLEWY TPMVNFDNVF NGYLSLFQVA TFKGWTIIMD HAIDSREVHQ QPVYENSILM
     YLYFVFFIIF GSFFTLNLFI GVIIDNFNEQ KKKGGGSREM LMTEDQKKYL NAMKKMGSKK
     PMKAIPRPRF KLQAIIFDIV TNKKFDMLIM LFIMLNMFVM SLDHYQASAF MEHILEMCNL
     FFIAVFTAEC MLKIFALRFH YFREPWNVFD FVIVILSIAS SALKDFVENY LISPTLLRVV
     RVVKIGRVLR LVKGARGIRT LLFALAMSLP ALFNICLLLF LVMFIYAIFG MSFFMNVKQR
     YGLDETFNFG TFFRSFILLF QMCTSAGWDG VLAAIMDESK CEKDSEVSDC GSKKIAIAYL
     VTYLIISFLV IVNMYIAVIL ENYSQATEDV QEGLTDDDYD MYYEIWQRFD PDGTQFISFN
     DLGEFLDALE EPLRVPRPNK FKIIQMDIPI CRNDMCYCVE ILDILTREFF ARKGKPIEET
     PELEEVLPLR GRFEHISSTF WRQREEYCAR IIQTAWLKYK ARKNAADGDD VFTDESMERN
     RASSIVGDDD GAGQTVNSKG HKVVIHSRSP SITSRSTDV
//
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